Abstract: Presented systems and methods enable efficient and effective radiation treatment planning and treatment, including accurate and convenient transmission of the radiation towards a tissue target. In one embodiment, a workflow for applying an irradiation scheme involving multiple steps is utilized to provide modulation of a particle beam. The workflow can include development of a treatment plan, generating configuration information for a modulation component based on the treatment plan, fabricating the modulation component, and using the modulation component in a system that delivers a radiation dose in accordance with the treatment plan.

Abstract: A method of planning radiation treatment for a patient includes identifying a region of interest of the patient to be treated with radiation and determining a simulated treatment plan for the region of interest based on a statistical analysis between one or more metrics of the identified region of interest and a previously determined predictive dynamics database that includes information regarding the one or more metrics for corresponding regions of interest for a population of patients. The method further includes characterizing the simulated treatment plan with a FLASH Index that compares an ideal FLASH radiation treatment plan to the simulated treatment plan.