Patents by Inventor Miriam Royo
Miriam Royo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115502Abstract: The present invention refers to a liposome comprising: a) a phospholipid; b) cholesterol (chol); c) a conjugate comprising a cholesterol moiety, a polyethylene glycol (PEG) moiety and a peptide moiety comprising a RGD sequence, wherein the PEG moiety is covalently attached to the cholesterol moiety by one end via a bond of the type alkyl ether and is covalently attached to the peptide moiety comprising the RGD sequence by the other end: d) a non-lipid cationic surfactant present in a percentage of less than 30% mol in respect to the total mol of the components of the liposome a), b), c) and d); and e) alpha-galactosidase (GLA) enzyme present in a ratio of micrograms of GLA in respect to the total milligrams of the components of the liposome a), b), c) and d) of between and including 2 to 35. It also refers to a pharmaceutical composition that comprises it and to the liposome or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of Fabry disease.Type: ApplicationFiled: January 26, 2022Publication date: April 11, 2024Inventors: Leonor VENTOSA RULL, Jaume VECIANA MIRÓ, Miriam ROYO EXPOSITO, Judit TOMSEN MELERO, Ibane ABASOLO OLAORTUA, Simón SCHWARTZ NAVARRO, Jose Luis CORCHERO NIETO, Daniel PULIDO MARTINEZ, Edgar CRISTÓBAL LECINA, Elisabet GONZÁLEZ MIRA, Santiago SALA VERGÉS, Alba CÓRDOBA INSENSÉ, Josep MERLO MAS, Andreu SOLDEVILA FÁBREGA, Albert FONT INGLÉS
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Patent number: 11242312Abstract: The present invention relates to dipeptidyl ketoamide m-methoxyphenyl derivatives and their use in the treatment of diseases and conditions associated with elevated calpain activity, such as heart injury caused by infarction, ischemia with or without reperfusion, neurodegenerative disorders, malaria, diabetic nephropathy, neurotoxicity induced by HIV virus, cancer, and fibrotic diseases.Type: GrantFiled: May 3, 2019Date of Patent: February 8, 2022Assignee: LANDSTEINER GENMED, S.L.Inventors: Jesús Llenas Calvo, Miriam Royo Expósito, Unai Elezcano Donaire, Enrique Vázquez Tatay, Marta Melgarejo Díaz, Marta Isabel Barranco Gallardo, Eva Ma Medina Fuentes
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Publication number: 20210317075Abstract: The present invention relates to dipeptidyl ketoamide m-methoxyphenyl derivatives and their use in the treatment of diseases and conditions associated with elevated calpain activity, such as heart injury caused by infarction, ischemia with or without reperfusion, neurodegenerative disorders, malaria, diabetic nephropathy, neurotoxicity induced by HIV virus, cancer, and fibrotic diseases.Type: ApplicationFiled: May 3, 2019Publication date: October 14, 2021Inventors: Jesús LLENAS CALVO, Miriam ROYO EXPÓSITO, Unai ELEZCANO DONAIRE, Enrique VÁZQUEZ TATAY, Marta MELGAREJO DÍAZ, Marta Isabel BARRANCO GALLARDO, Eva Mª MEDINA FUENTES
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DIPEPTIDYL KETOAMIDE COMPOUNDS AND THEIR USE FOR THE TREATMENT AND/OR PREVENTION OF FAT ACCUMULATION
Publication number: 20190270770Abstract: The present invention relates to the use of dipeptidyl ketoamide compounds for preventing accumulation of triglycerides in adipose tissue or for reducing the amount of triglycerides in adipose tissue in a subject in need thereof and to novel dipeptidyl ketoamide compounds.Type: ApplicationFiled: May 16, 2019Publication date: September 5, 2019Inventors: Jesús LLENAS CALVO, Miriam ROYO EXPOSITO, Elena CARCELLER GONZÁLEZ, Unai ELEZCANO DONAIRE, Sergio RODRIGUEZ ESCRICH, Enrique VAZQUEZ TATAY -
Dipeptidyl ketoamide compounds and their use for the treatment and/or prevention of fat accumulation
Patent number: 10294269Abstract: The present invention relates to the use of dipeptidyl ketoamide compounds for preventing accumulation of triglycerides in adipose tissue or for reducing the amount of triglycerides in adipose tissue in a subject in need thereof and to novel dipeptidyl ketoamide compounds.Type: GrantFiled: September 8, 2015Date of Patent: May 21, 2019Assignee: LANDSTEINER GENMED, S.L.Inventors: Jesús Llenas Calvo, Miriam Royo Exposito, Elena Carceller González, Unai Elezcano Donaire, Sergio Rodriguez Escrich, Enrique Vazquez Tatay -
DIPEPTIDYL KETOAMIDE COMPOUNDS AND THEIR USE FOR THE TREATMENT AND/OR PREVENTION OF FAT ACCUMULATION
Publication number: 20180237473Abstract: The present invention relates to the use of dipeptidyl ketoamide compounds for preventing accumulation of triglycerides in adipose tissue or for reducing the amount of triglycerides in adipose tissue in a subject in need thereof and to novel dipeptidyl ketoamide compounds.Type: ApplicationFiled: September 8, 2015Publication date: August 23, 2018Inventors: Jesús LLENAS CALVO, Miriam ROYO EXPOSITO, Elena CARCELLER GONZÁLEZ, Unai ELEZCANO DONAIRE, Sergio RODRIGUEZ ESCRICH, Enrique VAZQUEZ TATAY -
Patent number: 9744247Abstract: The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.Type: GrantFiled: June 28, 2013Date of Patent: August 29, 2017Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), FUNDACIÓ PARC CIENTÍFIC DE BARCELONA, CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA), UNIVERSITAT DE BARCELONA, FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON—INSTITUT DE RECERCA, UNIVERSITAT AUTÒNOMA DE BARCELONAInventors: Leonor Ventosa Rull, Jaume Veciana Miró, Ingrid Cabrera Puig, Elisa Elizondo Saez De Vicuña, Marta Melgarejo Diaz, Miriam Royo Expósito, Fernando Albericio Palomera, Daniel Pulido Martinez, Santiago Sala Vergés, Jose Luis Corchero Nieto, Simón Schwartz Navarro, Ibane Abasolo Olaortua, Antonio Pedro Villaverde Corrales
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Publication number: 20150190530Abstract: The invention relates to conjugates in which a sterol is functionalized by an ether bond with a water-soluble polymer to which a guiding ligand is bound. These conjugates improve the physico-chemical and delivery properties of their carrying vesicles, making these more stable, homogeneous and effective. A method for their preparation, a pharmaceutical composition containing said liposomes, and their therapeutic use are described as well.Type: ApplicationFiled: June 28, 2013Publication date: July 9, 2015Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), FUNDACIÓ PRIVADA PARC CIENTÍFIC DE BARCELONA, CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED EN BIONG- ENIERÍA, BIOMATERIALES Y NANOMEDICINA (CIBER-BBN), FUNDACIÓ PRIVADA INSTITUT DE RECERCA BIOMÈDICA, UNIVERSITAT DE BARCELONA, FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRON- INSTITUT DE RECERCA, UNIVERSITAT AUTÒNOMA DE BARCELONAInventors: Leonor Ventosa Rull, Jaume Veciana Miró, Ingrid Cabrera Puig, Elisa Elizondo Saez De Vicuña, Marta Melgarejo Diaz, Miriam Royo Expósito, Fernando Albericio Palomera, Daniel Pulido Martinez, Santiago Sala Vergés, Jose Luis Corchero Nieto, Simón Schwartz Navarro, Ibane Abasolo Olaortua, Antonio Pedro Villaverde Corrales
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Publication number: 20100129800Abstract: The present invention relates to a polymer composed by two to ten monomers of formula (I) as well as to a process for its preparation and its use as fluorophore wherein: X is a radical of formula (II) wherein —R5 is an electron pair or a (C1-C3)-alkyl radical; —Ra and —Rb are radicals independently selected from the group consisting of H, (C1-C4)-alKyI, (C1-C4)-alkoxy, (C1-C4)-alkylamino, phenyl, F, Cl, Br, amino, hydroxy, and nitro or —Ra and —Rb are fused forming with the carbon atoms to which they are attached a ring of formula (III) with the condition that (I) when —R5 is an electron pair, a is a N?C double bond, and Ra and Rb are fused forming the ring (III), said ring being a biradical selected from (IIIa) and (IIIb), thus, radical (II) is (IIa) or (IIb) respectively (II) when —R5 is a (C1-C3)-alkyl radical, a is a N—C single bond and Ra and Rb are fused forming the ring (III), said ring being a biradical (a), thus, the radical (II) is (IIc) R1-R4 and R7-R18 represent radicals, same or different, selectType: ApplicationFiled: July 9, 2008Publication date: May 27, 2010Inventors: Juan Aymami Bofarull, Fernando Albericio Palomera, Anna Maria Avino Andres, Josep Farrera Sinfreu, Miriam Royo Exposito, Isabel Navarro Munoz, Ramon Eritja Casadella
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Patent number: 7482429Abstract: A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity.Type: GrantFiled: February 9, 2001Date of Patent: January 27, 2009Assignee: Pharma Mar, S.A.Inventors: Fernando Albericio, Ernest Giralt, Jose Carlos Jimenez, Angel Lopez, Ignacio Manzanares, Ignacio Rodrigues, Miriam Royo
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Publication number: 20080318849Abstract: A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity.Type: ApplicationFiled: August 25, 2008Publication date: December 25, 2008Applicant: PHARMA MAR, S.A.Inventors: Fernando Albericio, Ernest Giralt, Jose Carlos Jimenez, Angel Lopez, Ignacio Manzanares, Ignacio Rodrigues, Miriam Royo
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Publication number: 20080269282Abstract: This invention is directed to inhibitors of copper-containing amine oxidases (E.C.1.4.3.6) including semicarbazide-sensitive amine oxidase (SSAO; also known as vascular adhesion protein-1, VAP-I), and their therapeutic use in inflammatory diseases, diabetes and its associated complications, atherosclerosis, neurodegenerative diseases, obesity, hypertension and cancer.Type: ApplicationFiled: August 2, 2005Publication date: October 30, 2008Applicant: GENMEDICA THERAPEUTICS SLInventors: Luc Marti Clauzel, Silvia Garcia Vicente, Francesc Yraola Font, Miriam Royo Exposito, Fernando Albericio Palomera, Antonio Zorzano Olarte
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Publication number: 20080227809Abstract: This invention provides compounds and pharmaceutical compositions thereof for treating human type 1 and type 2 diabetes, particularly insulin-resistant diabetes.Type: ApplicationFiled: July 1, 2005Publication date: September 18, 2008Applicants: GENMEDICA THERAPEUTICS SL, UNIVERSIDAD DE BARCELONAInventors: Miriam Royo Exposito, Luc Marti Clauzel, Anna Abella Marti, Silvia Garcia Vicente, Xavier Testar Ymbert, Antonio Zorzano Olarte, Manuel Palacin Prieto, Fernando Albericio Palomera, Francesc Yraola Font, Alec Mian
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Publication number: 20080070987Abstract: The invention provides compounds of Formula (I): and Formula (II) or a pharmaceutically-acceptable salt, solvate, or hydrate thereof. Compounds of this invention, or pharmaceutical compositions thereof, are useful for treating diabetes, elevated plasma glucose levels, and/or ketoacidosis in mammals.Type: ApplicationFiled: May 14, 2007Publication date: March 20, 2008Inventors: Francesc Yraola Font, Silvia Garcia Vicente, Juan Fernandez Recio, Fernando Albericio Palomera, Antonio Zorzano Olarte, Miriam Royo Exposito, Luc Marti Clauzel
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Publication number: 20070066646Abstract: This invention is directed to inhibitors of copper-containing amine oxidases (E.C. 1.4.3.6) including semicarbazide-sensitive amine oxidase (SSAO; also known as vascular adhesion protein-1, VAP-1), and their therapeutic use in inflammatory diseases, diabetes and its associated complications, atherosclerosis, neurodegenerative diseases, obesity, hypertension and cancer.Type: ApplicationFiled: August 2, 2006Publication date: March 22, 2007Applicant: GENMEDICA THERAPEUTICS SLInventors: Luc Clauzel, Francesc Font, Silvia Vicente, Miriam Royo Exposito, Fernando Palomera, Antonio Olarte
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Publication number: 20040214755Abstract: A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity.Type: ApplicationFiled: June 3, 2003Publication date: October 28, 2004Inventors: Fernando Albericio, Ernest Giralt, Jose Carlos Jimenez, Angel Lopez, Ignacio Manzanares, Ignacio Rodrigues, Miriam Royo