Abstract: Protease nexin-1 (PN-1) is a member of the serine protease inhibitor (Serpin)-family, with thrombin as its main target. Current polyclonal and monoclonal antibodies against PN-1 frequently cross-react with Plasminogen activator inhibitor-1 (PAI-1), a structurally and functionally homologous Serpin. Herein the inventors develop inhibitory single-domain antibodies (VHHs) showing specific binding to both human (hPN-1) and murine (mPN-1) PN-1 and which de not cross-react with PAI-1. Importantly, all VHHs could block PN-1 activity in plasma as well as PN-1 released from activated platelets, one of the main sources of PN-1 during hemostasis. Thus, the present invention relates to anti-protease nexin-1 (PN-1) conformational single domain antibodies and uses thereof in particular in the therapeutic field for the treatment of haemorrhagic diseases.

Abstract: The present invention relates in a first aspect to a method for the stratification of a therapeutic regimen of a subject afflicted or suspected to be afflicted with an immune regulatory antibody-mediated disease based on the immune status of said subject, the method is based on determining the level or amount of expression of PD-1 in a predetermined subset of B-cells, thus, reflecting the immune tolerance status against an immune tolerance inducing compound of said subject. In addition, a method for monitoring of the development or progress of a treatment in a subject based on an administration of immune-tolerance-inducing compound containing antigenic epitopes recognized by the B-cells producing these antibodies. Further, a method for determining the risk of developing antibody-producing B-cells based failure of immune tolerance induction (ITI) treatment in a subject is provided. Moreover, the use of PD-1 expression as a marker in antibody-mediated disease based on B-cell tolerance status is described.

Abstract: The invention relates to an oven door (10) for closing a cavity (2) of an oven (1) comprising a door window (11) being at least partially transparent for enabling a user to look into the oven cavity (2), wherein the door window (11) comprises at least one printing (12), the printing (12) being made of an ink comprising scattering components, said ink being transparent and wherein the oven door (10) is adapted to provide light to the printing (12) by at least one light source (13) such that said light is scattered by the scattering components of said printing (12) thereby implementing an optical user interface for displaying information at the door window (11).

Abstract: The present invention relates to an oven door (10) for an oven cavity (40) of a cooking oven (36). The oven door (10) comprises a first unit (12, 28) including a front panel (12) and at least two door columns (28) permanently attached at an inner side of said front panel (12) and a second unit including an inner glass panel (14) and a door frame (20) permanently attached at said inner glass panel (14). The door frame (20) includes an upper frame part (24) and two lateral frame parts (26), wherein the lateral frame parts (26) are permanently attached at an outer side of the inner glass panel (14) and the upper frame part (24) is permanently attached at upper ends of the lateral frame parts (26). The lateral frame parts (26) are connected or connectable to the door columns (28) in each case, so that the first unit (12, 28) and the second unit (14, 20) are detachably or permanently connected or connectable. A ventilation opening (30) is formed between the inner glass panel (14) and the upper frame part (24).

Abstract: The invention relates to an oven door (10) for closing a cavity (2) of an oven (1) comprising a door window (11) being at least partially transparent for enabling a user to look into the oven cavity (2), wherein the door window (11) comprises at least one printing (12), the printing (12) being made of an ink comprising scattering components, said ink being transparent and wherein the oven door (10) is adapted to provide light to the printing (12) by at least one light source (13) such that said light is scattered by the scattering components of said printing (12) thereby implementing an optical user interface for displaying information at the door window (11).