Patents by Inventor Mirko Liedtke

Mirko Liedtke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200201010
    Abstract: A microscope system having a plurality of microscope modules connected to one another for data transfer purposes. The microscope system includes a central clock generator, the clock signal of which is provided to all microscope modules. The microscope modules are configured to use the clock signal or a clock derived therefrom as an internal clock. Moreover, a corresponding method for operating such a microscope system is described.
    Type: Application
    Filed: April 30, 2018
    Publication date: June 25, 2020
    Applicant: Carl Zeiss Microscopy GmbH
    Inventors: Mirko LIEDTKE, Andreas KÜHM, Burkhard ROSCHER, Nico PRESSER
  • Publication number: 20200073102
    Abstract: A method for timing procedures in a microscope system, which has a plurality of microscope modules configured to carry out various processes, provision is made for a clock signal to be provided to all microscope modules by a central clock generator and for the clock signal to be modulated by a clock modulation circuit in order to produce a defined clock-pulse number. The microscope modules define a start time for carrying out a process by way of the clock-pulse number, carrying out the process as soon as the clock-pulse number is reached. Moreover, a corresponding microscope system is described.
    Type: Application
    Filed: April 30, 2018
    Publication date: March 5, 2020
    Applicant: Carl Zeiss Microscopy GmbH
    Inventors: Mirko LIEDTKE, Andreas KÜHM, Nico PRESSER, Burkhard ROSCHER
  • Publication number: 20190278047
    Abstract: An actuator for adjusting a movable element in a beam path of an optical arrangement, includes the movable element a carrier, and at least one SMA element, said SMA element being connected to the movable element and being designed so as to be supported on the carrier such that when the extension of the SMA element alters, a directed force effect is produced between said movable element and carrier.
    Type: Application
    Filed: September 27, 2017
    Publication date: September 12, 2019
    Applicant: Carl Zeiss Microscopy GmbH
    Inventors: Mirko Liedtke, Tobias Kaufhold, Franziska Tischer
  • Publication number: 20190208105
    Abstract: A method and arrangement for acquiring image data, wherein a pixel area of a specimen to be imaged is illuminated in a plurality of illumination events with illumination light of a respective selected intensity, which intensities are different from one another. Subsequently, detection light emanating from the respective pixel area is acquired for each of the intensities as image data of a subpixel and resulting image data of the pixel area are determined from the number of acquired image data of the subpixels. According to the invention, the illumination events are triggered successively. The image data of all subpixels of the pixel area are acquired before a further pixel area is illuminated.
    Type: Application
    Filed: August 14, 2017
    Publication date: July 4, 2019
    Applicant: Carl Zeiss Microscopy GmbH
    Inventors: Mirko LIEDTKE, Jakob HAARSTRICH
  • Patent number: 9927603
    Abstract: A switch which reduces the voltage between the photocathode and the first dynode in the activated switching state compared to the deactivated switching state and a control unit which is adapted to move a target spot, which can be illuminated by means of the light source, over a scanning field by means of a deflecting unit. The control unit activates the switch when the target spot enters a given region of the scanning field and deactivates the switch when the target spot exits the region.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: March 27, 2018
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Mirko Liedtke, Eva Simbuerger, Daniel Schwedt
  • Patent number: 9389403
    Abstract: The invention relates to a method for operating a microscope in which excitation light is focused on, or beamed to, different points of a specimen, in which an intensity of the excitation light is point-specifically varied and in which an intensity of the light reflected by said specimen in at least one spectral range is measured point-specifically and quantitatively. The method according to the invention is characterized in that the intensity and/or a spectral composition of the excitation light beamed to a specific point of said specimen is automatically adjusted by a regulating device on the basis of information previously gained from measured data of said specimen concerning an estimated or actual intensity of the light reflected in the spectral range by said point such that an integral of the intensity of the light reflected in the spectral range by this point during a pixel dwell time is within a predefined value interval. The invention also relates to a microscope.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: July 12, 2016
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Ingo Kleppe, Mirko Liedtke
  • Patent number: 8935127
    Abstract: A method for recording pulse signals which allows the reconstruction of a time reference. The time of every pulse signal event can be determined by counting sampling result bits preceding the respective sampling result bit using the known sampling frequency. For this purpose, every period of the sampling frequency is associated with a bit representing the respective sampling result and the sampling result bits are stored one by one and per channel in data blocks. The sampling frequency is preferably higher than a pixel clock, a sampling result bit associated with a flank of the pixel clock being marked. The pixel clock can thus be synchronized with the individual events exactly per sampling period. The invention further relates to the field of fluorescence correlation spectroscopy using confocal microscopes or laser scanning microscopes.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: January 13, 2015
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Mirko Liedtke, Frank Klemm, Manfred Loth
  • Publication number: 20140138517
    Abstract: A switch which reduces the voltage between the photocathode and the first dynode in the activated switching state compared to the deactivated switching state and a control unit which is adapted to move a target spot, which can be illuminated by means of the light source, over a scanning field by means of a deflecting unit. The control unit activates the switch when the target spot enters a given region of the scanning field and deactivates the switch when the target spot exits the region.
    Type: Application
    Filed: June 15, 2012
    Publication date: May 22, 2014
    Inventors: Mirko Liedtke, Eva Simbuerger, Daniel Schwedt
  • Publication number: 20140029091
    Abstract: The invention relates to a method for operating a microscope in which excitation light is focused on, or beamed to, different points of a specimen, in which an intensity of the excitation light is point-specifically varied and in which an intensity of the light reflected by said specimen in at least one spectral range is measured point-specifically and quantitatively. The method according to the invention is characterized in that the intensity and/or a spectral composition of the excitation light beamed to a specific point of said specimen is automatically adjusted by a regulating device on the basis of information previously gained from measured data of said specimen concerning an estimated or actual intensity of the light reflected in the spectral range by said point such that an integral of the intensity of the light reflected in the spectral range by this point during a pixel dwell time is within a predefined value interval. The invention also relates to a microscope.
    Type: Application
    Filed: October 9, 2013
    Publication date: January 30, 2014
    Applicant: Carl Zeiss Microimaging GmbH
    Inventors: Ingo Kleppe, Mirko Liedtke
  • Patent number: 8497464
    Abstract: To increase the sensitivity of detector arrangements, it is known that light deflection elements in the form of a line arrays having spherical elements may be used to focus incident light onto light-sensitive regions of the detector. Manufacturing such line arrays is complex and cost intensive, especially in small lot numbers. The increased sensitivity of the detector array can be achieved easily and inexpensively by using a novel light deflection element. The detector arrangement therefore has a light deflection element having light entrance surfaces, deflecting incident light by refraction onto light-sensitive regions of the detector. Light entrance surfaces of the light deflection element are inclined with respect to one another and are designed as planar surfaces. The detector arrangement is suitable in particular for detection of light emanating from a specimen in a microscope, preferably in a laser-scanning microscope.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: July 30, 2013
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Wolfgang Bathe, Michael Goelles, Mirko Liedtke
  • Patent number: 8253093
    Abstract: An optoelectronic detector and method of using same. In order to avoid any condensation on a surface, it has been known to heat such a surface. However, heating an optoelectronic detector will create a stronger hissing noise due to the greater dark current that is caused thereby. The invention is intended to avoid any condensation on an optoelectronic detector without airtight encapsulation. To this end, the detector is cooled and equipped with a sensor for the determination of a current value of one of the variables ambient humidity and ambient dew point temperature and a control unit that is connected with the sensor and designed to control the cooling device in dependence of such a value. By taking into account the ambient humidity or, respectively, the dew point temperature in the control of the cooling device, condensation on the detector can be avoided. An airtight encapsulation of the detector and the cooling device is not required.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: August 28, 2012
    Assignee: Carl Zeiss MicroImaging GmbH
    Inventors: Mirko Liedtke, Matthias John
  • Publication number: 20120162754
    Abstract: A laser scanning microscope comprising having a light source, an illuminating beam for illuminating a specimen with a spatially limited, preferably point-shaped, illuminating light spot via a scanning device and an objective lens, and a detection beam for detecting the specimen light that reaches the detection beam via the objective lens and the scanning device. Focusing means that are disposed in the detection beam and focus the light from the specimen to form a spatially limited detection light spot in a plane. Receiver elements are distributed in the spot in a matrix-like manner and can be individually read out. These are located in order to simulate an adjustable pinhole aperture.
    Type: Application
    Filed: December 22, 2011
    Publication date: June 28, 2012
    Inventor: Mirko LIEDTKE
  • Patent number: 7999238
    Abstract: An arrangement for signal processing at the output of a multichannel detector in the spectrally resolved acquisition of time-variable fluorescence phenomena in a microscope, particularly lifetime measurements, is characterized in that an FPGA (free programmable gate array) is arranged downstream of the output of the multichannel detector.
    Type: Grant
    Filed: July 16, 2007
    Date of Patent: August 16, 2011
    Assignee: Carl Zeiss MicroImaging GmbH
    Inventors: Ralf Wolleschensky, Mirko Liedtke
  • Publication number: 20110149388
    Abstract: A operating circuit and control method for protecting a PMT having a photocathode, a plurality of dynodes and an anode against overloading with a shorter reaction time, and to allow it to be switched on again rapidly. For this purpose, a switch is provided for electrically short circuiting the photocathode with the first dynode, or a switch is provided for reversing the polarity of the voltage between the photocathode and the first dynode.
    Type: Application
    Filed: December 16, 2010
    Publication date: June 23, 2011
    Applicant: CARL ZEISS MICROIMAGING GMBH
    Inventors: Mirko LIEDTKE, Johannes WEBER
  • Publication number: 20110119034
    Abstract: A method for recording pulse signals which allows the reconstruction of a time reference. The time of every pulse signal event can be determined by counting sampling result bits preceding the respective sampling result bit using the known sampling frequency. For this purpose, every period of the sampling frequency is associated with a bit representing the respective sampling result and the sampling result bits are stored one by one and per channel in data blocks. The sampling frequency is preferably higher than a pixel clock, a sampling result bit associated with a flank of the pixel clock being marked. The pixel clock can thus be synchronized with the individual events exactly per sampling period. The invention further relates to the field of fluorescence correlation spectroscopy using confocal microscopes or laser scanning microscopes.
    Type: Application
    Filed: December 16, 2010
    Publication date: May 19, 2011
    Applicant: CARL ZEISS MICROIMAGING GMBH
    Inventors: Mirko LIEDTKE, Frank KLEMM, Manfred LOTH
  • Publication number: 20110042555
    Abstract: To increase the sensitivity of detector arrangements, it is known that light deflection elements in the form of a line arrays having spherical elements may be used to focus incident light onto light-sensitive regions of the detector. Manufacturing such line arrays is complex and cost intensive, especially in small lot numbers. The increased sensitivity of the detector array can be achieved easily and inexpensively by using a novel light deflection element. The detector arrangement therefore has a light deflection element having light entrance surfaces, deflecting incident light by refraction onto light-sensitive regions of the detector. Light entrance surfaces of the light deflection element are inclined with respect to one another and are designed as planar surfaces. The detector arrangement is suitable in particular for detection of light emanating from a specimen in a microscope, preferably in a laser-scanning microscope.
    Type: Application
    Filed: August 16, 2010
    Publication date: February 24, 2011
    Applicant: CARL ZEISS MICROIMAGING GMBH
    Inventors: Wolfgang Bathe, Michael Goelles, Mirko Liedtke
  • Publication number: 20110032614
    Abstract: An optoelectronic detector and method of using same. In order to avoid any condensation on a surface, it has been known to heat such a surface. However, heating an optoelectronic detector will create a stronger hissing noise due to the greater dark current that is caused thereby. The invention is intended to avoid any condensation on an optoelectronic detector without airtight encapsulation. To this end, the detector is cooled and equipped with a sensor for the determination of a current value of one of the variables ambient humidity and ambient dew point temperature and a control unit that is connected with the sensor and designed to control the cooling device in dependence of such a value. By taking into account the ambient humidity or, respectively, the dew point temperature in the control of the cooling device, condensation on the detector can be avoided. An airtight encapsulation of the detector and the cooling device is not required.
    Type: Application
    Filed: August 4, 2010
    Publication date: February 10, 2011
    Applicant: Carl Zeiss Microlmaging GmbH
    Inventors: Mirko LIEDTKE, Matthias John
  • Patent number: 7869123
    Abstract: Specimen laser-scanning microscope with raster scanning illumination and detector modules, which illuminates and detects a specimen by raster scanning. A real-time control device (device) performs synchronous reading-out with the raster scanning pixel cycle. A data port serially communicates with the device using a bidirectional high-speed data stream and with the resources via a serial, bidirectional high-speed data stream with a data conversion to/from parallel to serial. The high-speed data stream is made up of data packets with data bits and type bits and no additional header or protocol bits. The data bits contain data from/on the resources and the type bits code the type of data. Type information is stored in the resources as well as the device. The type information defines processing functions for data types coded by the type bits, and the resources and/or the device determine the data type using type bits and process data coded in the data bits.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: January 11, 2011
    Assignee: Carl Zeiss MicroImaging GmbH
    Inventors: Gunter Moehler, Mirko Liedtke
  • Patent number: 7859673
    Abstract: A method for detecting and analyzing light signals, in which a light signal impinges an optoelectric converter, where it is converted into an electric signal and the electric signal subsequent to the conversion is distributed into several analysis channels (13.1-13.4), within each analysis channel (13.1), (i) a signal analysis is performed, which is different from the signal analysis for the other analysis channels (13.2-13.4) and (ii) an output signal is created. In such a method, one or more output signals are selected for further processing and output using a specified, changeable selection criterion.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: December 28, 2010
    Assignee: Carl Zeiss MicroImaging GmbH
    Inventors: Gunter Moehler, Dietmar Schmidt, Mirko Liedtke
  • Publication number: 20100208339
    Abstract: The invention relates to a method for operating a microscope in which excitation light is focused on, or beamed to, different points of a specimen, in which an intensity of the excitation light is point-specifically varied and in which an intensity of the light reflected by said specimen in at least one spectral range is measured point-specifically and quantitatively. The method according to the invention is characterized in that the intensity and/or a spectral composition of the excitation light beamed to a specific point of said specimen is automatically adjusted by a regulating device on the basis of information previously gained from measured data of said specimen concerning an estimated or actual intensity of the light reflected in the spectral range by said point such that an integral of the intensity of the light reflected in the spectral range by this point during a pixel dwell time is within a predefined value interval. The invention also relates to a microscope.
    Type: Application
    Filed: July 24, 2008
    Publication date: August 19, 2010
    Inventors: Ingo Kleppe, Mirko Liedtke