Abstract: The present invention relates to optimizing a health state of a patient. An apparatus comprises a) means for receiving a patient-specific value of at least one parameter; b) means for generating a profile for the patient based at least in part on the patient-specific value; c) means for selecting a stored profile out of one or more stored profiles of the patient and/or of other patients in a storage medium, the selecting based on a comparison of the stored profile and the generated profile for the patient, wherein the stored profile comprises a stored feedback and a stored patient-specific value of the at least one parameter; and d) means for providing feedback to patient based on the stored feedback.

Abstract: Devices, systems, and methods herein relate to cooling a head of a patient. These systems and methods may comprise a cooling cap assembly comprising a heat exchanger configured to be wrapped around a head of a patient and a compression assembly releasably coupled to the heat exchanger. The compression assembly may comprise an enclosure and an inflatable member coupled to an internal surface of the enclosure. When coupled, the inflatable member may be positioned between the enclosure and the heat exchanger. The heat exchanger may be separate from and moveable relative to the inflatable member.

Abstract: Devices, systems, and methods herein relate to cooling a head of a patient. These systems and methods may comprise a cooling cap assembly comprising a heat exchanger configured to be wrapped around a head of a patient and a compression assembly releasably coupled to the heat exchanger. The compression assembly may comprise an enclosure and an inflatable member coupled to an internal surface of the enclosure. When coupled, the inflatable member may be positioned between the enclosure and the heat exchanger. The heat exchanger may be separate from and moveable relative to the inflatable member.

Abstract: The present invention refers to a liposome comprising: a) a phospholipid; b) cholesterol (chol); c) a conjugate comprising a cholesterol moiety, a polyethylene glycol (PEG) moiety and a peptide moiety comprising a RGD sequence, wherein the PEG moiety is covalently attached to the cholesterol moiety by one end via a bond of the type alkyl ether and is covalently attached to the peptide moiety comprising the RGD sequence by the other end: d) a non-lipid cationic surfactant present in a percentage of less than 30% mol in respect to the total mol of the components of the liposome a), b), c) and d); and e) alpha-galactosidase (GLA) enzyme present in a ratio of micrograms of GLA in respect to the total milligrams of the components of the liposome a), b), c) and d) of between and including 2 to 35. It also refers to a pharmaceutical composition that comprises it and to the liposome or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of Fabry disease.

Abstract: A medical system comprising a patch device and a computer. The patch device is in communication with the computer. The patch device is configured for generating measurement data or providing a therapy. The patch device comprises electronic circuitry, a battery, an antenna system, one or more sensors, an IMU (inertial measurement unit), and a flexible enclosure. The antenna system can comprise a dual antenna formed on a dielectric substrate with a first antenna on a first side of the dielectric substrate and a second antenna on a second side of the dielectric substrate. The one or more sensors can comprise devices configured to provide measurement data or a therapy. The IMU is configured to measure position, movement, and trajectory of the patch device. The electronic circuitry is configured to harvest energy from one or more radio frequency signals received by the antenna system to recharge the battery.

Abstract: The present application provides a method and a system for recycling a polymer. The method includes introducing polymer into a primary melting extruder, producing a polymer melt that is combined with a fluid oil to at least partially dissolve the polymer melt. A secondary mixing extruder mixes these to form a polymer solution that is introduced into a refinery oil stream, producing a polymer-comprising oil stream, which is fed into a refinery process unit. The system includes a primary melting extruder for forming a polymer melt from polymer. A secondary mixing extruder receives the polymer melt. One or more hydrocarbon inflow conduits for providing a fluid oil to the primary melting extruder and/or the secondary mixing extruder are configured to form a polymer solution from the fluid oil and the polymer melt. There is a feed system outlet for feeding the polymer solution to a refinery oil stream.

Abstract: An orthopedic system configured for pre-operative, intra-operative and post-operative assessment of a musculoskeletal system. The orthopedic system comprises a first screw, a second screw, a first device, a second device, and a computer. The first screw and the second screw are respectively coupled in a first bone and a second bone of a musculoskeletal system. The first and second screws each include electronic circuitry, one or more sensors, and an IMU. In one embodiment, a first device and a second device can be respectively located in proximity to the first and second screws. The first and second devices respectively transmit a radio frequency signal to the first and second screws. The first and second screws harvest a predetermined amount of energy and then are enabled to perform at least one task and an orderly shutdown. The computer receives measurement data from the first and second screws.

Abstract: Acoustic and other activity detection signaling is provided herein. Operations of a method can include determining a micro-electromechanical system (MEMS) device is no longer in an initialization state and receiving a first signal that instructs the MEMS device to perform event activity detection. The method can also include receiving one or more event signals and determining that an event signal of one or more event signals satisfies a defined event characteristic. The method can also include outputting a second signal that comprises information indicative of a detection of event activity at the MEMS device being more than the defined event characteristic.

Abstract: A junction box comprises parallel-connected switches comprising at least a first switch and a second switch. A first current sensor senses current through the first switch. A second current sensor senses current through the second switch. A controller is in communication with the first and second current sensors. The controller modifies operation of the junction box in response to detecting at least one of the switches is failed. The controller detects that one of the first switch and the second switch is failed when the current through the first switch and the current through the second switch are unbalanced.

Abstract: A medical system comprising a first medical device, a second medical device, and a computer. The first medical device is configured to be placed beneath the dermis. The first medical device comprises an enclosure comprising non-electrically conductive material. A cap couples to the enclosure and is configured to seal the enclosure. The enclosure houses electronic circuitry configured to measure one or more parameter or provide a therapy. The cap couples to the ground of the electronic circuitry. The first medical device includes a dual band antenna. A first antenna is configured to operate within a first frequency band below 1 gigahertz. The second antenna is configured to operate at a frequency above 1 gigahertz. The second medical device is configured to transmit a radio frequency signal to the first medical device. The first medical device is configured to harvest the energy received from the radio frequency signal to enable the electronic circuitry and perform at least one task.

Abstract: A gas turbine engine is provided having a static structure including a flowpath wall. A fluid circuit is extended through the flowpath wall and includes a first inlet opening in fluid communication with a first cavity to receive a first flow of fluid through the fluid circuit. The static structure includes an ejector positioned at the fluid circuit, in which the ejector includes a second inlet opening in fluid communication with a second cavity to receive a second flow of fluid through the ejector and into the fluid circuit.

Abstract: A medical system comprising a patch device and a computer. The patch device is in communication with the computer. The patch device is configured for generating measurement data or providing a therapy. The patch device comprises electronic circuitry, a battery, an antenna system, one or more sensors, an IMU (inertial measurement unit), and a flexible enclosure. The antenna system can comprise a dual antenna formed on a dielectric substrate with a first antenna on a first side of the dielectric substrate and a second antenna on a second side of the dielectric substrate. The one or more sensors can comprise devices configured to provide measurement data or a therapy. The IMU is configured to measure position, movement, and trajectory of the patch device. The electronic circuitry is configured to harvest energy from one or more radio frequency signals received by the antenna system to recharge the battery.

Abstract: An orthopedic system configured for use in a pre-operative, intra-operative, and post-operative assessment. The orthopedic system comprises a first screw, a second screw, a first device, a second device, and a computer. The first device and the second device are respectively coupled to a first bone and a second bone of a musculoskeletal system. The first and second devices each include electronic circuitry, one or more sensors, and an IMU. A bracket, wrap, or sleeve can be used to hold the first and second devices to the musculoskeletal system. The first and second devices are configured to send measurement data to a computer. The first and second devices each have an antenna system. Electronic circuitry in the first or second devices are configured to harvest energy from a received radio frequency signal to recharge a battery to maintain operation.

Abstract: In a method for efficiently and accurately measuring the intelligibility of speech, a user may utter a sample text, and an automatic speech assessment (ASA) system may receive an acoustic signal encoding the utterance. An automatic speech recognition (ASR) module may generate an N-best output corresponding to the utterance and generate an intelligibility score representing the intelligibility of the utterance based on the N-best output and the sample text. Generating the intelligibility score may involve (1) calculating conditional intelligibility value(s) for the N recognition result(s), and (2) determining the intelligibility score based on the conditional intelligibility value of the most intelligible recognition result. Optionally, the process of generating the intelligibility score may involve adjusting the intelligibility score to account for environmental information (e.g., a pronunciation score for the user's speech and/or a confidence score assigned to the 1-best recognition result).

Abstract: A switch arrangement for providing alternative distribution paths in a system for distributing electrical power in a vehicle including electrical power supplies and electrical loads. The switch arrangement includes a first switch adapted to be connected to a first electrical element, a second switch adapted to be connected to the first electrical element and a second electrical element, and a third switch adapted to be connected to the electrical element and a third electrical element. Each of the first, second, and third switches is independently controllable, and selective operation of each of the first, second, and third switches to its open or closed state interconnects at least two of the first, second, and third electrical elements to establish one of multiple alternative distribution paths to connect one of the power supplies and one of the loads or to connect two of the power supplies.

Abstract: A medical system comprising a first medical device, a second medical device, and a computer. The first medical device is configured to be placed beneath the dermis. The first medical device comprises an enclosure comprising non-electrically conductive material. A cap couples to the enclosure and is configured to seal the enclosure. The enclosure houses electronic circuitry configured to measure one or more parameter or provide a therapy. The cap couples to the ground of the electronic circuitry. The first medical device includes a dual band antenna. A first antenna is configured to operate within a first frequency band below 1 gigahertz. The second antenna is configured to operate at a frequency above 1 gigahertz. The second medical device is configured to transmit a radio frequency signal to the first medical device. The first medical device is configured to harvest the energy received from the radio frequency signal to enable the electronic circuitry and perform at least one task.

Abstract: Described herein is a system for hybrid denture fabrication. The system improve the efficiency of the fabrication process for both the dental service provider (e.g., dentist, dental surgeon, etc.) and the patient. A permanent hybrid prosthesis (e.g., the bridge and its reinforcing bar) can be fabricated within 24 hours of the surgical procedure using the system described herein. This makes it possible to deliverer the permanent hybrid prosthesis within 48 hours (or even within 24 hours) of the surgical procedure. Additionally, the system eliminates the need to provide the patient with a temporary denture following the surgery. Further, the system substantially reduces the patient's chair-time and/or the number of patient visits.

Abstract: A colposcope includes an inserter including an elongated body defining an interior space and an image capture device configured to be selectively and slidably positioned within the interior space of the elongated body. The elongated body has a distal end portion and a proximal end portion. The distal end portion is substantially funnel shaped and has a distal end that includes first and second portions. The first portion includes a base at a first edge of the distal end, and the second portion includes a lip at a second edge of the distal end that is diametrically opposed from the first edge. The lip is positioned further from the proximal end portion than the base.

Abstract: A wireless system comprising a first wireless device and a second wireless device. The first wireless device is configured to operate with less than 15 milliamperes of current. The second wireless device has an internal power source and is configured to transmit one or more radio frequency signals to the first wireless device. The first wireless device is configured to receive the one or more radio frequency signals from the second wireless device. The first wireless device is configured to harvest energy from the one or more radio frequency signals. The first wireless device is enabled for operation after a predetermined amount of energy is harvested from the one or more radio frequency signals. A communication handshake occurs between the first and second wireless devices to indicate that the first wireless device is in communication with the second wireless device. The first wireless device is configured to perform at least one task from harvested energy.

Abstract: The invention provides a human IL-2 (hlL-2)-specific monoclonal antibody, wherein a complex of hlL-2 and the monoclonal induces IL-2 signalling preferentially via CD25 and the trimeric IL-2R. The invention further provides a pharmaceutical composition comprising hlL-2 and said hlL-2-mAb for use treating inflammatory disease.