Abstract: A composition for relieving stress and/or disorder caused by stress is provided, which composition comprises lysine and arginine as active ingredients. The lysine and arginine may be in the form of a salt. In a preferred mode, the cause of stress is any one selected from the group consisting of mental strain, repetitive work, intellectual labor, menopausal mental instability, anxiety and strain with respect to a future event and premenstrual mental instability and strain.

Abstract: Administering or ingesting a combination of lysine with another agent for stress-related diseases other than lysine provides an improvement in the treatment and prevention of stress-related diseases (enhanced drug efficacy) and reduced side effects. Such combinations of lysine with another agent for stress-related diseases other than lysine can be employed in the form of a medicine (including a medicine for animals), a food, a drink or a feed, and are highly useful in preventing, treating, or ameliorating various stress-related diseases and preventing the progress of such diseases. The two ingredients as described above can be administered or ingested either at the same time or at different points and in different forms.

Abstract: The present invention provides animal model of chronic stress diseases produced by feeding lysine deficient diet to the animals and a method for producing the animal model. The effect of medicine on chronic stress diseases can be judged with the animal model. Effective compounds in preventing chronic stress diseases and/or treating patients suffering from chronic stress diseases can be screened by using the animal model.

Abstract: The present invention relates to an agent for treating and/or preventing stress-induced diseases, and a pharmaceutical composition (pharmaceutical product), a food, drink, or a feed containing the same. More specifically, the present invention relates to an agent (pharmaceutical drug) containing lysine as the active (effective) ingredient, and a pharmaceutical product, a food, a drink, or a feed containing the agent (pharmaceutical drug). Furthermore, the present invention relates to a method for suppressing stress, and a method for the therapeutic treatment, amelioration and/or prevention of stress-induced diseases, as well as a use of lysine for anti-stress agents or stress suppressor.