Patents by Inventor Miroslav V. Bobek

Miroslav V. Bobek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-substituted arabinopyranosyl nucleosides and nucleotides
    Patent number: 4918056
    Abstract: Novel arabinopyranosyl nucleoside derivatives having the heterocyclic moiety and fluorine at the 2' position of the sugar ring (pyranose configuration), which have antitumor, antiviral and antimicrobial properties, are prepared by condensation of a pyrimidine, purine or 1,3-oxazine base with an acylated 2-deoxy-2,2-difluoro-D-arabinopyranoside and/or acylated 2-deoxy-2-bromo-2-fluoro-D-arabinopyranoside.
    Type: Grant
    Filed: October 14, 1986
    Date of Patent: April 17, 1990
    Assignee: Health Research, Inc. (Roswell Park Division)
    Inventors: Miroslav V. Bobek, Seung-Ho An, Ralph J. Bernacki
  • Process of preparing 2-azido-2-deoxyarabinofuranosyl halides
    Patent number: 4321366
    Abstract: Novel arabinofuranosyl nucleosides and nucleotides having 2'-azido,2'-amino, or 2'-hydrocarbylamino substituents, which have antitumor, antiviral, and antimicrobial properties, are prepared by condensation of a pyrimidine, purine, or 1,3-oxazine base with an acylated 2-azido-2-deoxyarabinofuranosyl halide, followed by deblocking and catalytic hydrogenation, where appropriate, to convert the 2'-azido group to a 2'-amino group and, if desired, alkylation or the like to convert the 2'-amino group to a 2'-hydrocarbylamino group.
    Type: Grant
    Filed: June 3, 1980
    Date of Patent: March 23, 1982
    Assignee: Research Corporation
    Inventors: Miroslav V. Bobek, Alexander Bloch, Yung-Chi Cheng
  • 2-Substituted arabinofuranosyl nucleosides and nucleotides
    Patent number: 4230698
    Abstract: Novel arabinofuranosyl nucleosides and nucleotides having 2'-azido, 2'-amino, or 2'-hydrocarbylamino substituents, which have antitumor, antiviral, and antimicrobial properties, are prepared by condensation of a pyrimidine, purine, or 1,3-oxazine base with an acylated 2-azido-2-deoxyarabinofuranosyl halide, followed by deblocking and catalytic hydrogenation, where appropriate, to convert the 2'-azido group to a 2'-amino group and, if desired, alkylation or the like to convert the 2'-amino group to a 2'-hydrocarbylamino group.
    Type: Grant
    Filed: May 12, 1978
    Date of Patent: October 28, 1980
    Assignee: Research Corporation
    Inventors: Miroslav V. Bobek, Alexander Bloch, Yung-Chi Cheng