Patents by Inventor Miroslav Zabadal

Miroslav Zabadal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing idelalisib
    Patent number: 9981965
    Abstract: The present invention relates to an improved process for preparing Idelalisib (1). In this process, acid addition salts of idelalisamine (2) are useful intermediates for purification purposes.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: May 29, 2018
    Assignee: Synthon B.V.
    Inventors: Libor Vyklicky, Miroslav Zabadal
  • IMPROVED PROCESS FOR PREPARING IDELALISIB
    Publication number: 20180093987
    Abstract: The present invention relates to an improved process for preparing Idelalisib (1). In this process, acid addition salts of idelalisamine (2) are useful intermediates for purification purposes.
    Type: Application
    Filed: March 24, 2016
    Publication date: April 5, 2018
    Inventors: Libor VYKLICKY, Miroslav ZABADAL
  • Process for making bortezomib and intermediates for the process
    Patent number: 8884009
    Abstract: The invention relates to processes of making bortezomib of formula (1) enantiomers thereof and/or intermediates thereof, comprising at least one step of coupling a carboxylic acid with an amine, wherein the coupling step is performed in a presence of the compound of formula (8), wherein A is C1-C6 alkyl group, preferably wherein A is n-propyl group.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: November 11, 2014
    Assignee: Synthon BV
    Inventors: Jakub Castulik, Miroslav Zabadal
  • PROCESS FOR MAKING BORTEZOMIB AND INTERMEDIATES FOR THE PROCESS
    Publication number: 20130203988
    Abstract: The invention relates to processes of making bortezomib of formula (1) enantiomers thereof and/or intermediates thereof, comprising at least one step of coupling a carboxylic acid with an amine, wherein the coupling step is performed in a presence of the compound of formula (8), wherein A is C1-C6 alkyl group, preferably wherein A is n-propyl group.
    Type: Application
    Filed: October 14, 2010
    Publication date: August 8, 2013
    Applicant: Synthon BV
    Inventors: Jakub Castulik, Miroslav Zabadal