Patents by Inventor Mirth T. Hoyt

Mirth T. Hoyt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Colorimetric Substrate and Methods for Detecting Poly(ADP-ribose) Polymerase Activity including PARP Enzymes PARP-1, VPARP, and Tankyrase-1
    Publication number: 20080176261
    Abstract: Disclosed are compositions and methods capable of facilitating the detection and measurement of poly(ADP-ribose)polymerases (PARP enzymes). PARP enzyme activity can be monitored using a novel calorimetric substrate, ADP-ribose-para-nitrophenol. The substrate can be synthesized from beta nicotinamide adenine dinucleotide (?-NAD+) and para-nitrophenol. In an embodiment, a continuous assay was developed to detect and kinetically monitor activity for PARP enzymes such as PARP-1, tankyrase-1 (PARP-5), and VPARP (PARP-4). The compositions and methods are particularly useful in the screening and identification of specific PARP inhibitors.
    Type: Application
    Filed: January 18, 2007
    Publication date: July 24, 2008
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Amanda C. Nottbohm, Robin Shane Dothager, Karson S. Putt, Mirth T. Hoyt, Paul J. Hergenrother