Abstract: Various sequences of new peptides and derivatives with anti-inflammatory effects in various cellular models (chondrocytes osteoclasts, macrophages derived from THP-1, and neurons) in the context of stimulus-induced inflammation widely known in the literature for each model. The compounds were shown to be able to reverse the expression of molecules associated with the cell's inflammatory mechanism, in addition to inducing regenerative proteins and reducing pain markers. Accordingly, the claimed compounds of the present invention can be applied to degenerative diseases of an inflammatory nature including rheumatoid arthritis and osteoarthritis.

Abstract: The invention pertains to the technical fields of pharmaceutical sciences, immunology, diagnosis and/or treatment of cancer. Specifically, the invention relates to peptides derived from the C-terminal portion of the tick amblyomin-X protein, said peptides being intended for targeting or promoting the internalization of molecular entities into the intracellular domain of eukaryotic or neoplastic cells. The invention also relates to the use of said peptides for modifying other pharmaceutically active ingredients, to a pharmaceutical composition comprising said peptides and to a method of diagnosis, prognosis and/or treatment of cancer or other cell-altering conditions.