Patents by Inventor Misayo Sera
Misayo Sera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230088365Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: October 7, 2022Publication date: March 23, 2023Inventors: Tomomi Ikemoto, Misayo Sera, Naohiro Fukuda, Hideya Mizufune, Toshiaki Nagata, Takeshi Yamasaki
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Publication number: 20210070705Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: September 15, 2020Publication date: March 11, 2021Inventors: Tomomi Ikemoto, Misayo Sera, Naohiro Fukuda, Hideya Mizufune, Toshiaki Nagata, Takeshi Yamasaki
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Publication number: 20200115336Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: November 22, 2019Publication date: April 16, 2020Inventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
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Publication number: 20190127324Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: November 26, 2018Publication date: May 2, 2019Inventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
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Patent number: 10173977Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: GrantFiled: January 13, 2016Date of Patent: January 8, 2019Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
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Publication number: 20180009746Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: January 13, 2016Publication date: January 11, 2018Inventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
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Publication number: 20140303378Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: June 12, 2014Publication date: October 9, 2014Inventors: Tomomi IKEMOTO, Hideya MIZUFUNE, Toshiaki NAGATA, Misayo SERA, Naohiro FUKUDA, Takeshi YAMASAKI
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Patent number: 8822694Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: GrantFiled: February 24, 2010Date of Patent: September 2, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Misayo Sera, Naohiro Fukuda
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Publication number: 20130345444Abstract: Provided is a production method of an optically active dihydrobenzofuran derivative. A production method of an optically active form of a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof and the like.Type: ApplicationFiled: February 16, 2012Publication date: December 26, 2013Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Mitsuhisa Yamano, Mitsutaka Goto, Takeshi Kajiwara, Hiroyuki Maeda, Takahiro Konishi, Misayo Sera, Yuichiro Kondo, Seiji Yamasaki
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Publication number: 20110306769Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.Type: ApplicationFiled: February 24, 2010Publication date: December 15, 2011Applicant: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Hideya Mizufune, Toshiaki Nagata, Misayo Sera, Naohiro Fukuda, Takeshi Yamasaki
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Publication number: 20090326229Abstract: To provide methods for preparing alpha-carboline derivatives in few steps, as well as conveniently and industrially advantageously.Type: ApplicationFiled: August 2, 2007Publication date: December 31, 2009Applicant: Takeda Phamaceutical Company LimitedInventors: Masahiro Mizuno, Hideya Mizufune, Misayo Sera, Masahiro Mineno, Tsuyoshi Ueda
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Publication number: 20080287438Abstract: The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a divalent acyclic hydrocarbon group; Z is —O—, —S—, —NR2—, —CONR2— or —NR2CO— (R2 is a hydrogen atom or an optionally substituted alkyl group); Y is a bond or a divalent acyclic hydrocarbon group; R1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be —O—, or a salt thereof.Type: ApplicationFiled: July 15, 2008Publication date: November 20, 2008Inventors: Yu Momose, Nozomu Sakai, Tsuyoshi Maekawa, Masatoshi Hazama, Toru Kawamura, Misayo Sera
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Patent number: 7420070Abstract: A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: [wherein R1 and R2 are each hydrogen or an optionally substituted hydrocarbon group; R3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.Type: GrantFiled: February 9, 2005Date of Patent: September 2, 2008Assignee: Takoda Pharmaceutical Company LimitedInventors: Isao Aoki, Mari Adachi, Hiroyuki Tawada, Makoto Yamashita, Misayo Sera
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Publication number: 20070238721Abstract: The present invention provides an industrial production method with a short process having a high yield of an aliphatic cyclic carboxamide having carboxyl group, which comprises reacting functional group-selectively using an inexpensive condensing agent without protecting the carboxyl group by esterification, that is, reacting carboxylic acid anhydride obtained by reacting carboxylic acid and tertiary carboxylic acid halide with aliphatic cyclic secondary amine having carboxyl group.Type: ApplicationFiled: June 10, 2005Publication date: October 11, 2007Applicant: Takeda Pharmaceutical Company LimitedInventors: Atsushi Inagaki, Misayo Sera
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Publication number: 20060004069Abstract: The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a divalent acyclic hydrocarbon group; Z is —O—, —S—, —NR2—, —CONR2— or —NR2CO— (R2 is a hydrogen atom or an optionally substituted alkyl group); Y is a bond or a divalent acyclic hydrocarbon group; R1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be —O—, or a salt thereof.Type: ApplicationFiled: October 30, 2003Publication date: January 5, 2006Inventors: Yu Momose, Nozomu Sakai, Tsuyoshi Maekawa, Masatoshi Hazama, Toru Kawamura, Misayo Sera
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Publication number: 20050171184Abstract: A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: [wherein R1 and R2 are each hydrogen or an optionally substituted hydrocarbon group; R3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.Type: ApplicationFiled: February 9, 2005Publication date: August 4, 2005Inventors: Isao Aoki, Mari Adachi, Hiroyuki Tawada, Makoto Yamashita, Misayo Sera
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Patent number: 6878831Abstract: A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: [wherein R1 and R2 are each hydrogen or an optionally substituted hydrocarbon group; R3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.Type: GrantFiled: December 27, 2001Date of Patent: April 12, 2005Assignee: Takeda Chemical Industries, Ltd.Inventors: Isao Aoki, Mari Adachi, Hiroyuki Tawada, Makoto Yamashita, Misayo Sera
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Publication number: 20040077712Abstract: A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: 1Type: ApplicationFiled: June 24, 2003Publication date: April 22, 2004Inventors: Isao Aoki, Mari Adachi, Hiroyuki Tawada, Makoto Yamashita, Misayo Sera