Patents by Inventor Mishel Ashkar

Mishel Ashkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing opipramol
    Patent number: 5599929
    Abstract: An improved method for preparing opipramol (I) is disclosed, wherein iminostilbene (II) is reacted with 1-bromo-3-chloropropane in the presence of a weak base selected from a hydrogen phosphate salt and an acetate salt and in the presence of a phase transfer agent to produce N-(3-halopropyl)iminostilbene (III), which is mixture of N-(3-chloropropyl)iminostilbene and N-(3-bromopropyl)iminostilbene, and then N-(3-halopropyl)iminostilbene is reacted with N-(2-hydroxyethyl)piperazine to form opipramol, as shown in the following equations, where X is chlorine or bromine.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: February 4, 1997
    Assignee: Taro Pharmaceutical Industries Ltd
    Inventors: Daniella Gutman, Mishel Ashkar