Abstract: An external load bearing distracting device, which can be positioned to fully unload a knee joint cartilage while providing the knee joint normal motion, for an articulating anatomical joint. The device includes a first and second rotatable threaded rods arranged longitudinally on opposite sides of a rotating joint, and first and second translational tubes slidably arranged around the first and second rotatable threaded rods, respectively. The rotating joint may comprise a ball-and-ring-joint configured for accommodating a two mutually complementary brake elements. The first and second rotatable threaded rods each include a first and second clamping nuts thereon, which contact a proximal end of the first and second translational tube to limit longitudinal translation thereof towards the rotating joint. The distracting device is intended for temporary implantation to treat osteoarthritis, focal cartilage defects, and fractures inside the knee joint.

Abstract: An external load bearing distracting device, which can be positioned to fully unload a knee joint cartilage while providing the knee joint normal motion, for an articulating anatomical joint. The device includes first and second rotatable extensions arranged longitudinally on opposite sides of the joint, and first and second translational inserts slidably arranged inside the first and second rotatable extensions, respectively. The joint may comprise a ball-and-ring-joint or a cardan joint. The first and second translational inserts include a threaded portion and a pair of threaded nuts thereon, which abut a retainer on each of the first and second rotatable extensions to limit longitudinal translation. The external load-bearing distracting device is temporarily attached to the patient, preferably for a period of 6 to 8 weeks, and is intended for use to treat osteoarthritis, focal cartilage defects, and fractures inside the knee joint, among other conditions of articulating anatomical joints.

Abstract: Methods and compositions are described to regenerate cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising an infiltration suppressor agent and a columnar growth promoting agent.

Abstract: Methods and compositions are described to regenerate cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising an infiltration suppressor agent and a columnar growth promoting agent.

Abstract: Methods and compositions are described to regenerate cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising an infiltration suppressor agent and a columnar growth promoting agent.

Abstract: Methods and compositions are described to regenerate cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising an infiltration suppressor agent and a columnar growth promoting agent.