Abstract: Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.

Abstract: A method of anastomosing two hollow bodily organs using a bioadhesive. The method involves apposing apertures in the organs to be joined and applying the bloadhesive, thereby joining the apertures in the organs and allowing movement of fluid or semi-solid material from one of the two organs to the second organ. A device for anastomosing two hollow organs. The device has two inflatable balloons, one of which is placed into the lumen of each of the two organs to be joined. Inflation of the balloons holds the apertures together while the bioadhesives is applied. The device allows for endoscopic anastomosis of blood vessels.

Abstract: A method of anastomosing two hollow bodily organs using a bioadhesive. The method involves apposing apertures in the organs to be joined and applying the bioadhesive, thereby joining the apertures in the organs and allowing movement of fluid or semi-solid material from one of the two organs to the second organ. The invention also relates to a device for anastomosing two hollow organs. The device has two inflatable balloons, one of which is placed into the lumen each of the two organs to be joined. Inflation of the balloons holds the apertures together while the bioadhesive is applied. The device allows anastomosis of blood vessels through endoscopic means.