Patents by Inventor Mitchell A. Avery
Mitchell A. Avery has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090192152Abstract: The present invention provides a method of preventing or treating one or more of the following medical conditions, or treating symptoms of one or more of the following medical conditions: amebic infections, giardiasis, estrogen deficient states, osteoporosis, cardiovascular heart disease, high cholesterol levels, hyperlipidemia, cancer by administering to a subject having, or predisposed to, one or more of the conditions, a therapeutically effective amount of a compound of the present invention and a pharmaceutically acceptable carrier.Type: ApplicationFiled: December 23, 2008Publication date: July 30, 2009Inventors: Mitchell Avery, Larry A. Walker, Nakul Telang
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Patent number: 7468445Abstract: The present invention provides a method of preventing or treating one or more of the following medical conditions, or treating symptoms of one or more of the following medical conditions: amebic infections, giardiasis, estrogen deficient states, osteoporosis, cardiovascular heart disease, high cholesterol levels, hyperlipidemia, cancer by administering to a subject having, or predisposed to, one or more of the conditions, a therapeutically effective amount of a compound of the present invention and a pharmaceutically acceptable carrier.Type: GrantFiled: August 7, 2003Date of Patent: December 23, 2008Assignee: University of MississippiInventors: Mitchell Avery, Larry A. Walker, Nakul Telang
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Patent number: 7339065Abstract: This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.Type: GrantFiled: July 21, 2004Date of Patent: March 4, 2008Assignees: Bethesda Pharmaceuticals, Inc., The University of MississippiInventors: Mitchell A. Avery, Harrihar A. Pershadsingh
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Publication number: 20070099969Abstract: This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.Type: ApplicationFiled: July 21, 2004Publication date: May 3, 2007Inventors: Mitchell Avery, Harrihar Pershadsingh
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Publication number: 20060106091Abstract: The present invention provides a method of preventing or treating one or more of the following medical conditions, or treating symptoms of one or more of the following medical conditions: amebic infections, giardiasis, estrogen deficient states, osteoporosis, cardiovascular heart disease, high cholesterol levels, hyperlipidemia, cancer by administering to a subject having, or predisposed to, one or more of the conditions, a therapeutically effective amount of a compound of the present invention and a pharmaceutically acceptable carrier.Type: ApplicationFiled: August 7, 2003Publication date: May 18, 2006Inventors: Mitchell Avery, Larry Walker, Nakul Telang
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Patent number: 6989450Abstract: The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compound thereby to form a third compound selected from the formulas: and stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof.Type: GrantFiled: October 15, 2001Date of Patent: January 24, 2006Assignee: The University of MississippiInventor: Mitchell A. Avery
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Publication number: 20050240034Abstract: Described herein is the synthesis, bioassay results and utility of new C-9 and C-10 substituted artemisinin derivatives with easily functionalizable groups attached to the artemisinin skeleton through carbon chain or heteroatoms. Described also is the demonstration of this class of compounds for their broad-spectrum anti-parasitic activity. Certain of these analogs possess noticeable cytotoxicity deliberately focused on treatment of cancerous diseases.Type: ApplicationFiled: May 7, 2003Publication date: October 27, 2005Inventors: Mitchell Avery, Kannoth Muraleedharan
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Publication number: 20050020654Abstract: The present invention provides novel compounds and pharmaceutical compositions thereof, which at least partially activate PPAR? and may further inhibit the activity of the AT1 receptor. The novel compounds include certain substituted benzimidazole compounds of Formulae I and II, infra. The invention also provides methods of treating inflammatory and metabolic disorders and methods for screening compounds for the capability to treat or prevent an inflammatory or metabolic disorder.Type: ApplicationFiled: March 15, 2004Publication date: January 27, 2005Inventors: Harrihar Pershadsingh, Mitchell Avery
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Publication number: 20020091269Abstract: The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof.Type: ApplicationFiled: October 15, 2001Publication date: July 11, 2002Inventor: Mitchell A. Avery
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Patent number: 6369098Abstract: The present invention describes methods for synthesizing novel dithiolane derivatives, ligands with high affinity for the nuclear hormone receptors, peroxisome proliferator-activated receptor-&ggr; (PPAR&ggr;) and/or PPAR&agr;. Methods for using these compounds in the treatment of endocrine, skin, cardiovascular, immunological, neurological, neuropsychiatric, neoplastic and chronic viral diseases of various organs, including the eye are described. Methods of treating proliferative and inflammatory diseases, degenerative diseases, and age-related dysregulations, caused by an hereditary (genetic) condition or an environmental insult are also provided.Type: GrantFiled: October 4, 2000Date of Patent: April 9, 2002Assignee: Bethesda Pharmaceuticals, Inc.Inventors: Harrihar A. Pershadsingh, Mitchell A. Avery
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Patent number: 6353011Abstract: This invention provides new thiazolindinedione derivatives and new arylacetic acid derivatives. These compounds are useful for the treatment of cardiovascular diseases, certain endocrine diseases, certain inflammatory diseases, certain neoplastic (malignant) and non-malignant proliferative diseases, certain neuro-psychiatric disorders, certain viral diseases, and diseases associated with these viral infections as discussed herein.Type: GrantFiled: March 7, 2000Date of Patent: March 5, 2002Assignee: University of MississippiInventors: Harrihar A. Pershadsingh, Mitchell A. Avery
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Patent number: 6204288Abstract: This invention provides new thiazolindinedione derivatives and new arylacetic acid derivatives. These compounds are useful for the treatment of certain cardiovascular certain diseases, certain endocrine diseases, certain inflammatory diseases, certain neoplastic (malignant) and non-malignant proliferative diseases, certain neuro-psychiatric disorders, certain viral diseases, and diseases associated with these viral infections as discussed herein.Type: GrantFiled: February 3, 2000Date of Patent: March 20, 2001Assignee: The University of MississippiInventors: Harrihar A. Pershadsingh, Mitchell A. Avery
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Patent number: 6127394Abstract: This invention provides new thiazolindinedione derivatives and new arylacetic acid derivatives. These compounds are useful for the treatment of certain cardiovascular certain diseases, certain endocrine diseases, certain inflammatory diseases, certain neoplastic (malignant) and non-malignant proliferative diseases, certain neuro-psychiatric disorders, certain viral diseases, and diseases associated with these viral infections as discussed herein.Type: GrantFiled: March 8, 1999Date of Patent: October 3, 2000Assignee: The University of MississippiInventors: Harrihar A. Pershadsingh, Mitchell A. Avery
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Patent number: 6087385Abstract: The present invention provides thiazolidinediones which are useful as antiproliferative, antiinflammatory and antiinfective agents. These compounds are useful for the treatment of certain endocrine diseases including diabetes, certain malignant and non-malignant proliferative diseases including prostate cancer, breast cancer, psoriasis, and acne, certain cardiovascular disorders including hypertension and occlusive vascular diseases.Type: GrantFiled: November 3, 1999Date of Patent: July 11, 2000Assignee: University of MississippiInventors: Harrihar A. Pershadsingh, Mitchell A. Avery
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Patent number: 6028088Abstract: The present invention provides thiazolidinediones which are useful as antiproliferative, antiinflammatory and antiinfective agents. These compounds are useful for the treatment of certain endocrine diseases including diabetes, certain malignant and non-malignant proliferative diseases including prostate cancer, breast cancer, psoriasis, and acne, certain cardiovascular disorders including hypertension and occlusive vascular diseases.Type: GrantFiled: October 30, 1998Date of Patent: February 22, 2000Assignee: The University of MississippiInventors: Harrihar A. Pershadsingh, Mitchell A. Avery
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Patent number: 5688780Abstract: Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R is a C-17 side chain, R.sup.1 is --OH, .dbd.O, or the like, and X and Y are CH, C--OH, C--OCH.sub.3 or C--Z. Methods of using the compound of formula (I) or other novel oxysterol analogs to treat hypercholesterolemia are provided, as are pharmaceutical compositions containing the compounds.Type: GrantFiled: February 29, 1996Date of Patent: November 18, 1997Assignee: SRI InternationalInventors: Wesley K. M. Chong, Wan-Ru Chao, Dennis M. Yasuda, John G. Johansson, Mitchell A. Avery, Masato Tanabe
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Patent number: 5510340Abstract: Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R is a C-17 side chain, R.sup.1 is --OH, .dbd.O, or the like, and X and Y are N, N.fwdarw.O, CH, C--OH, C--OCH.sub.3 or C--Z. Methods of using the compound of formula (I) or other novel oxysterol analogs to treat hypercholesterolemia are provided, as are pharmaceutical compositions containing the compounds.Type: GrantFiled: June 12, 1992Date of Patent: April 23, 1996Assignee: SRI InternationalInventors: Wesley K. M. Chong, Wan-Ru Chao, Dennis M. Yasuda, John G. Johansson, Mitchell A. Avery, Masato Tanabe
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Patent number: 5225554Abstract: A process for synthesizing polyoxa tetracyclics which involves the ozonolysis of a single-ring-structure vinyl silane with resulting direct formation of the desired multiple ring material. The polyoxa tetracyclic compounds have the formula ##STR1## The vinyl silanes have the structure ##STR2## The vinyl silanes are new chemical compounds as are corresponding primary ozonide and dioxetane intermediates. In a preferred embodiment, this invention provides a total synthesis of the antimalarial artemisinin.Type: GrantFiled: July 18, 1990Date of Patent: July 6, 1993Assignee: SRI InternationalInventors: Mitchell A. Avery, Clive Jennings-White
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Patent number: 5216175Abstract: Polyoxoheterocyclic tetracycles related to the Chinese antimalarial natural product qinghaosu (artemisinin) are disclosed. These materials have a ##STR1## core structure with an oxygen (carbonyl or alkyl ether) at position 12 and in some cases one or two alkyl or aralkyl substituents at position 11. These materials have antimalarial properties.Type: GrantFiled: March 23, 1990Date of Patent: June 1, 1993Assignee: SRI InternationalInventors: Mitchell A. Avery, Wesley K. M. Chong, James E. Bupp
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Patent number: 5180840Abstract: A process for synthesizing oxygen-containing polyoxatetracycle compounds and in particular analogs of the antimalarial agent known as qinghaosu or artemisinin is disclosed. The process employs as a reactant an olefinically unsaturated bicyclic bridging ketone having nonenolizable bridgehead moieties for both of its alpha positions. This ketone is converted to a vinylsilane that is subjected to ozonolytic cleavage of its olefinic bond to yield a member of a family of unique carboxyl/carbonyl-substituted vinylsilanes which may in turn optionally be subjected to a wide range of reactions prior to a final ozonolysis/acidification step which closes the oxygen-containing ring structure. The various intermediates are claimed as aspects of this invention as are novel tetracycles and their use as antimalarials.Type: GrantFiled: February 19, 1991Date of Patent: January 19, 1993Assignee: SRI InternationalInventors: Mitchell A. Avery, Wesley K. M. Chong