Abstract: Systems and methods for dynamic online signaling are disclosed. Embodiments of these systems and methods may determine when a user is online or when a user is otherwise performing certain activities and dynamically signal an interested entity based on the user's activity.

Abstract: Non-invasive blood pressure (NIBP) systems and methods are disclosed that measure a blood pressure, and in some examples a beat-to-beat blood pressure, of a patient without restricting blood flow. The NIBP systems determine an efficacy of administered cardiopulmonary resuscitation (CPR) to the patient based on the measured blood pressure and are able to optionally output the CPR efficacy or generate user prompts based on the CPR efficacy. Further, the disclosed NIBP systems can generate user instructions to administer further treatment to the patient based on the CPR efficacy.

Abstract: Techniques for displaying workflow responses based on determining topics associated with user requests are discussed herein. In some examples, a user may post a request (e.g., question) to a virtual space (e.g., a channel, thread, board, etc.) of a communication platform. The communication platform may input the request into a machine learning model trained to identify topics associated with the request and confidence levels associated with topics. In such examples, the communication platform may associate a topic with the user request based on the confidence level of the topic. In some examples, the communication platform may determine that the topic is associated with a graphical identifier (e.g., emoji). The communication platform may cause the graphical identifier to be displayed to the virtual space within which the user request was posted. In response to displaying the graphical identifier, the communication platform may display a workflow response to the virtual space.

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: A carrier card for reduced width circuit card assemblies are described. The carrier card includes a U-shaped design. A daughter card mounts in a void in the carrier card in a co-planar fashion. The carrier card includes an upper member; a lateral member, a lower member and a front panel with optional snout. The lateral member or other member includes a carrier card electrical and/or optical connector. The lower member or other member includes a mating electrical and/or optical connector to connect with the daughter card. The upper member, the lateral member, and the lower member form or define the void. A front panel connects with the upper and lower member and, optionally, the daughter card to provide structural integrity and provides additional I/O for the assembly.

Abstract: Technologies and implementations for a defibrillator electrode having communicative capabilities are generally disclosed.

Abstract: A nozzle for an electrochemical machining device. The nozzle defining a body with first and second releasably attachable body portions forming an electrolyte cavity therebetween, when the first and second body portions are attached. The body includes an inlet port upstream of the cavity, and an outlet port for dispensing a jet of electrolyte towards a surface of a workpiece, in use, where a flow path is defined from the inlet port through the cavity to the outlet port.

Abstract: A prehospital telemedicine system comprises a physiologic monitor; an electronic patient care reporting system (ePCR) system; and a point-of-care blood analyzer communicatively coupled to the physiologic monitor and the ePCR system. The point-of-care blood analyzer is configured to perform an analysis of a blood sample based on an indication of a need for a specific blood analysis provided by one of the physiologic monitor and the ePCR system, and to automatically transmit a result of the analysis to a remote data receiving system. The indication of a need for a specific blood analysis may be based upon any one of the following: vital signs data obtained for a patient by the physiologic monitor; and/or current documentation or past medical history captured on or available through the ePCR system.

Abstract: A CPR machine (100) is configured to perform, on a patient's (182) chest, compressions that alternate with releases. The CPR machine includes a compression mechanism (148), and a driver system (141) configured to drive the compression mechanism. A force sensing system (149) may sense a compression force, and the driving can be adjusted accordingly if there is a surprise. For instance, driving may have been automatic according to a motion-time profile, which is adjusted if the compression force is not as expected (850). An optional chest-lifting device (152) may lift the chest between the compressions, to assist actively the decompression of the chest. A lifting force may be sensed, and the motion-time profile can be adjusted if the compression force or the lifting force is not as expected.

Abstract: A CPR machine (100) is configured to perform, on a patient's (182) chest, compressions that alternate with releases. The CPR machine includes a compression mechanism (148), and a driver system (141) configured to drive the compression mechanism. A force sensing system (149) may sense a compression force, and the driving can be adjusted accordingly if there is a surprise. For instance, driving may have been automatic according to a motion-time profile, which is adjusted if the compression force is not as expected (850). An optional chest-lifting device (152) may lift the chest between the compressions, to assist actively the decompression of the chest. A lifting force may be sensed, and the motion-time profile can be adjusted if the compression force or the lifting force is not as expected.

Abstract: An electrolyte solution is provided for an electrochemical machining process. The electrolyte solution includes a substantially water free ionic solvent, an ionisable material in the form of an inorganic salt; and a viscosity modifier. The electrolyte has a viscosity in the range of 1 to 50 mPa·s at 20° C.

Abstract: An electro-discharge machining (EDM) device that includes a housing, an erosion electrode, a ground electrode, and a dielectric inlet. The housing is configured to be positioned on a surface of a workpiece and proximal to a fastener to be eroded. The planar erosion electrode is positioned at least partially within the housing, with the erosion electrode being movable relative to the housing in a first axis. The first axis is substantially normal to a longitudinal axis of the fastener. The ground electrode is conductively connected to the fastener. The dielectric inlet is configured to deliver a dielectric fluid to a region between the erosion electrode and the fastener.

Abstract: A defibrillation device for administering an electrotherapy, such as a dual-sequential defibrillation (DSD) electrotherapy. The defibrillation device can include a defibrillation therapy module, a physiological parameter module and a control module. The defibrillation therapy module can output one or more energies and the physiological parameter module can receive one or more physiological parameters, including electrocardiogram (ECG) data. The control module can analyze the physiological parameters to determine an indication for the administration of an electrotherapy and can determine a DSD electrotherapy. The DSD electrotherapy can be based at least in part on the physiological parameters, the indication for the administration of an electrotherapy or a review of the ECG data.

Abstract: Aspects of the present disclosure relate to adverse user behavior detection and mitigation. In examples, a user account of a social platform may be trusted or untrusted. If the user account is untrusted, activity of the user account may be buffered so as to not directly affect social metrics of the social platform. For example, if the untrusted user account follows a target user account, the untrusted user account may be added to a separate set of followers or otherwise separated from a set of trusted followers of the target user account. Eventually, each user account in the separate set is evaluated to determine whether the user account has transitioned to a trusted user. If the user account is now trusted, it may be migrated to the set of trusted followers. However, if the user account is untrusted, it may be removed from the separate set, thereby reverting the activity.

Abstract: A status monitoring function that simplifies the process of collecting status information for medical devices in a medical device system. Matrix codes are used to associate a medical device with a location. A maintenance application transmits the association information to a centralized tracking system. Status information about the medical device is also transmitted to the centralized tracking system from the maintenance application.

Abstract: A platform for implementing a method of aggregating and contextualizing metrics relevant to developing, launching and marketing a target therapeutic or related therapy. The method of processing the metrics includes retrieving data related to the target from one or more data sources and synthesizing the retrieved target data in a contextual manner and creating synthesized target data by converting unstructured data into structured data including an event, wherein an event comprises a corpus of data from a single source on a single date. The synthesized target data is stored in a target specific database and a user may query the database regarding the target, where the query includes at least one search parameter. The user query is processed against the synthesized target data in the target specific database and the results are presented to the user.

Abstract: Non-invasive blood pressure (NIBP) systems and methods are disclosed that measure a blood pressure, and in some examples a beat-to-beat blood pressure, of a patient without restricting blood flow. The NIBP systems determine an efficacy of administered cardiopulmonary resuscitation (CPR) to the patient based on the measured blood pressure and are able to optionally output the CPR efficacy or generate user prompts based on the CPR efficacy. Further, the disclosed NIBP systems can generate user instructions to administer further treatment to the patient based on the CPR efficacy.

Abstract: Technologies and implementations for a defibrillator electrode having communicative capabilities are generally disclosed.