Patents by Inventor Mitchell A. Winnik
Mitchell A. Winnik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210356376Abstract: This disclosure relates to reagents and their use for elemental imaging mass spectrometry of biological samples.Type: ApplicationFiled: September 9, 2019Publication date: November 18, 2021Applicants: Fluidigm Canada Inc., The Governing Council of the University of TorontoInventors: Taunia Closson, Vladimir Baranov, Mitchell A. Winnik
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Patent number: 10871436Abstract: The invention relates to a new type of element encoded particles suitable for the attachment of bio molecules to enable massively multiplex bio-analytical methods, and to calibrate and tune the elemental flow cytometer mass spectrometer (FC-MS).Type: GrantFiled: August 31, 2016Date of Patent: December 22, 2020Assignee: Fluidigm Canada Inc.Inventors: Mitchell A. Winnik, Cedric Van-Caeyzeele, Vladimir I. Baranov
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Publication number: 20200362062Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: May 5, 2020Publication date: November 19, 2020Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
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Patent number: 10752707Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: July 9, 2019Date of Patent: August 25, 2020Assignee: FLUIDIGM CANADA INC.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
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Patent number: 10669358Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: July 27, 2018Date of Patent: June 2, 2020Assignee: FLUIDIGM CANADA INC.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
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Publication number: 20190345272Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: July 9, 2019Publication date: November 14, 2019Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
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Publication number: 20190077890Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: July 27, 2018Publication date: March 14, 2019Applicant: FLUIDIGM CANADA INC.Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
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Patent number: 10072104Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: October 5, 2015Date of Patent: September 11, 2018Assignee: Fluidigm Canada Inc.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
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Publication number: 20160370277Abstract: The invention relates to a new type of element encoded particles suitable for the attachment of bio molecules to enable massively multiplex bio-analytical methods, and to calibrate and tune the elemental flow cytometer mass spectrometer (FC-MS) (FIG. 1).Type: ApplicationFiled: August 31, 2016Publication date: December 22, 2016Inventors: Mitchell A. Winnik, Cedric Van-Caeyzeele, Vladimir I. Baranov
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Patent number: 9465036Abstract: The invention relates to a new type of element encoded particles suitable for the attachment of bio molecules to enable massively multiplex bio-analytical methods, and to calibrate and tune the elemental flow cytometer mass spectrometer (FC-MS).Type: GrantFiled: November 2, 2007Date of Patent: October 11, 2016Assignee: Fluidigm Canada Inc.Inventors: Mitchell A. Winnik, Cedric Vancaeyzeele, Vladimir I. Baranov
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Patent number: 9296838Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: March 16, 2015Date of Patent: March 29, 2016Assignee: Fluidigm Canada, Inc.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
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Publication number: 20160025731Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: October 5, 2015Publication date: January 28, 2016Inventors: MITCHELL A. WINNIK, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
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Patent number: 9169335Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: March 16, 2015Date of Patent: October 27, 2015Assignee: Fluidigm Canada, Inc.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
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Publication number: 20150183895Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: March 16, 2015Publication date: July 2, 2015Inventors: Mitchell A. Winnik, MARK NITZ, VLADIMIR BARANOV, XUDONG LOU
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Patent number: 9012239Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: GrantFiled: May 28, 2007Date of Patent: April 21, 2015Assignee: Fluidigm Canada Inc.Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
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Publication number: 20100144056Abstract: The invention relates to a new type of element encoded particles suitable for the attachment of bio molecules to enable massively multiplex bio-analytical methods, and to calibrate and tune the elemental flow cytometer mass spectrometer (FC-MS).Type: ApplicationFiled: November 2, 2007Publication date: June 10, 2010Inventors: Mitchell A. Winnik, Cedric Vancaeyzeele, Vladimir I. Baranov
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Publication number: 20080003616Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).Type: ApplicationFiled: May 28, 2007Publication date: January 3, 2008Inventors: Mitchell Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
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Patent number: 7087677Abstract: This invention relates to copolymer compositions having pigment like properties, comprising a fluorescent or non-fluorescent dye attached to a polymer chain by a spacer having a chain length of C3 or longer. The invention also provides for new mono- and difunctional dye monomers comprising a polymerizable group attached to a dye moiety by a spacer of a chain length of C3 or longer. The polymer pigments provide excellent properties, especially high temperature stability and easy applicability as colorant in different standard polymers.Type: GrantFiled: February 20, 2002Date of Patent: August 8, 2006Inventors: Bansi Lal Kaul, Jean-Christophe Graciet, Mitchell A. Winnik, Frederic Tronc, Mei Li, Jianping Lu
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Publication number: 20060088713Abstract: The present invention provides a method of surface passivation of colloidal nanocrystalline materials using a ligand exchange process in which quantum nanoparticles of pre-selected size and shape has polymer multidentate ligands bound at the surface of the nanocrystals for stabilizing quantum size-dependent properties of nanocrystals and providing colloidal stability of the nanoparticles in solvents.Type: ApplicationFiled: May 5, 2005Publication date: April 27, 2006Inventors: Tieneke Dykstra, Xiao-Song Wang, Mayrose Salvador, Gregory Scholes, Mitchell Winnik, Jung Oh
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Publication number: 20040063889Abstract: This invention relates to copolymer compositions having pigment like properties, comprising a fluorescent or non-fluorescent dye attached to a polymer chain by a spacer having a chain length of C3 or longer.Type: ApplicationFiled: August 12, 2003Publication date: April 1, 2004Inventors: Bansi Lal Kaul, Jean-Christophe Graciet, Mitchell A. Winnik, Frederic Tronc, Mei Li, Jianping Lu