Patents by Inventor Mitchell C. Sanders
Mitchell C. Sanders has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230345944Abstract: The development, formulations, and uses of a purified and enhanced hydrogen peroxide-based surface disinfectant. The disinfectant is optimized to provide for the rapid inactivation and killing of microorganisms including but not limited to Clostridium difficile, Methicillin Resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Candida auris, and several viruses such as COVID-19. The hard surface disinfectant is optimized to impart a formulation that has rapid disinfection of microbial pathogens (less than or equal to 45 seconds) and once incorporated into a liquid or moistened wipe provides a cleaning and disinfecting solution which is nonslip and noncorrosive, while leaving minimal residue on the surface.Type: ApplicationFiled: July 5, 2023Publication date: November 2, 2023Inventors: Mitchell C. Sanders, Lindsay Poland, Basnet Prabhat
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Publication number: 20220289869Abstract: An ultra-rapid method for the isolation and purification of high molecular weight hyaluronic acid (HA) from the skin of reptiles (rHA). The method utilizes an extraction buffer that inhibits unwanted hyaluronidases, filtration to remove cell debris and precipitated proteins, and a highly substituted anion exchange column at a low pH with a high salt elution to maximize the yield and purity of rHA per kilogram of skin. rHA is extremely charged and elutes between 1.6-3M NaCl. Our findings suggest that rHA is high molecular weight (>2 mDa) and has a profound ability to enhance cell migration and proliferation for wound repair and regeneration. Preliminary evidence suggests that scaffolds of rHA are ideal for biomaterial engineering that could be incorporated into several medical devices and pharmaceutical products.Type: ApplicationFiled: May 31, 2022Publication date: September 15, 2022Inventors: Mitchell C. Sanders, Da Wei
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Publication number: 20190091370Abstract: Disclosed herein is a wound dressing having a wound-contacting surface comprising a KAP-enriched keratin material in the form of a hydrogel or a coating on a substrate wherein said KAP content facilitates accelerated wound healing of chronic wounds that exhibit excessive or persistence proteolytic enzyme activity.Type: ApplicationFiled: September 10, 2018Publication date: March 28, 2019Inventors: Mitchell C. Sanders, Thomas H. Barrows
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Patent number: 9435805Abstract: The present invention is directed to a method for the ultrasensitive detection of beta hemolytic Streptococcus, a bacterium implicated in strep throat, using a specific protease marker. Also disclosed is a device as well as a biosensor, both of which are useful for the detection of beta hemolytic Streptococcus. The biosensor and the device can be used in conjunction with other reagents as part of a kit for detecting strep throat.Type: GrantFiled: September 22, 2011Date of Patent: September 6, 2016Assignee: Woundchek Laboratories (US), Inc.Inventors: Mitchell C. Sanders, Dale Macy, Andrei Rakitin, Courtney Mankus
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Patent number: 9315851Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the ?1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and/or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: GrantFiled: December 18, 2014Date of Patent: April 19, 2016Assignee: Woundchek Laboratories (US), Inc.Inventors: Shite Sebastian, Gerard J. Colpas, Diane L. Ellis-Busby, Jennifer M. Harvard, Mitchell C. Sanders
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Publication number: 20150184220Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the ?1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and/or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: ApplicationFiled: December 18, 2014Publication date: July 2, 2015Inventors: Shite Sebastian, Gerard J. Colpas, Diane L. Ellis-Busby, Jennifer M. Harvard, Mitchell C. Sanders
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Patent number: 9017963Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: GrantFiled: January 31, 2003Date of Patent: April 28, 2015Assignee: Woundchek Laboratories (US), Inc.Inventors: Mitchell C. Sanders, Adrian M. Lowe, Maureen A. Hamilton, Gerard J. Colpas
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Patent number: 8927204Abstract: Described herein is a substrate comprising at least one colorimetric component attached to a peptide, as well as methods for detecting a modification of said substrate. Also described are methods of detecting the presence or absence of a protein, for example, a protein produced by a microorganism, by contacting a substrate with a sample. If the sample contains the protein of interest, the substrate is modified and a visible color change results, indicating the presence or absence of the protein in the sample. The present invention also features biosensors and kits for detecting the presence or absence of microorganisms and/or proteins in a sample.Type: GrantFiled: November 3, 2004Date of Patent: January 6, 2015Assignee: WoundChek Laboratories, Inc.Inventors: Mitchell C. Sanders, Gerard J. Colpas, Diane L. Ellis-Busby, Jennifer M. Havard
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Publication number: 20140322790Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the ?1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and/or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: ApplicationFiled: December 13, 2013Publication date: October 30, 2014Applicant: WOUNDCHEK LABORATORIESInventors: Shite Sebastian, Gerard J. Colpas, Diane L. Ellis-Busby, Jennifer M. Harvard, Mitchell C. Sanders
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Publication number: 20140220589Abstract: The present invention is directed to a method for the ultrasensitive detection of beta hemolytic Streptococcus, a bacterium implicated in strep throat, using a specific protease marker. Also disclosed is a device as well as a biosensor, both of which are useful for the detection of beta hemolytic Streptococcus. The biosensor and the device can be used in conjunction with other reagents as part of a kit for detecting strep throat.Type: ApplicationFiled: September 22, 2011Publication date: August 7, 2014Applicant: Systagenix Wound Management (US) Inc.Inventors: Mitchell C. Sanders, Dale Macy, Andrei Rakitin
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Publication number: 20140051089Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: ApplicationFiled: July 23, 2013Publication date: February 20, 2014Applicant: Systagenix Wound Management (US), Inc.Inventors: Mitchell C. Sanders, Adrian M. Lowe, Maureen A. Hamilton, Gerard J. Colpas
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Patent number: 8609353Abstract: Described herein are substrates, methods, articles, and kits that are useful for removing interferents from samples for diagnostic purposes. The interferents are removed with phosphocellulose and cation exchange materials. These materials could also be used in vitro to improve the performance of a diagnostic assay or in vivo to remove the interferents.Type: GrantFiled: February 2, 2007Date of Patent: December 17, 2013Assignee: Systagenix Wound Management (US), Inc.Inventors: Mitchell C. Sanders, Diane L. Ellis-Busby, Jennifer M. Havard, James C. Comolli
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Patent number: 8609358Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the ? 1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and/or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: GrantFiled: November 3, 2004Date of Patent: December 17, 2013Assignee: Systagenix Wound Management (US), Inc.Inventors: Shite Sebastian, Gerard J. Colpas, Diane L. Ellis-Busby, Jennifer M. Havard, Mitchell C. Sanders
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Patent number: 8377651Abstract: Described herein are methods of detecting an infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: GrantFiled: September 30, 2010Date of Patent: February 19, 2013Assignee: Systagenix Wound Management (US), Inc.Inventors: Gerard J. Colpas, Diane Ellis-Busby, Shite Sebastian, Mitchell C. Sanders
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Publication number: 20120135440Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a cationic anti-microbial peptide that is degradable by an enzyme produced and/or secreted by a microorganism, and detecting degradation or the absence of degradation of the peptide, as an indicator of the presence or absence of the enzyme in the sample, and thus indicative of the presence or absence of a microorganism in the sample. The present invention also features a biosensor for detecting the presence or absence of a microorganism in a sample.Type: ApplicationFiled: December 22, 2011Publication date: May 31, 2012Applicant: Systagenix Wound Management (US), INC.Inventors: Mitchell C. Sanders, Gerard J. Colpas, Shite Sebastian, Diane Ellis-Busby
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Patent number: 8124370Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a cationic anti-microbial peptide that is degradable by an enzyme produced and/or secreted by a microorganism, and detecting degradation or the absence of degradation of the peptide, as an indicator of the presence or absence of the enzyme in the sample, and thus indicative of the presence or absence of a microorganism in the sample. The present invention also features a biosensor for detecting the presence or absence of a microorganism in a sample.Type: GrantFiled: January 30, 2004Date of Patent: February 28, 2012Assignee: Systagenix Wound Management (US), Inc.Inventors: Mitchell C. Sanders, Gerard J. Colpas, Shite Sebastian, Diane Ellis-Busby
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Patent number: 8039228Abstract: Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a target for a protein produced by a microorganism. When the substrate is modified by a protein produced by a microorganism, the enzyme is activated. The zymogens can be used to amplify detection assays.Type: GrantFiled: September 2, 2004Date of Patent: October 18, 2011Assignee: Expressive Constructs, Inc.Inventors: Gerard J. Colpas, Shite Sebastian, Mitchell C. Sanders
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Publication number: 20110070594Abstract: Described herein are methods of detecting an infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: ApplicationFiled: September 30, 2010Publication date: March 24, 2011Applicant: SYSTAGENIX WOUND MANAGEMENTInventors: Gerard J. Colpas, Diane Ellis-Busby, Shite Sebastian, Mitchell C. Sanders
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Publication number: 20100221758Abstract: The present invention provides biosensors and methods of use for detecting the presence or absence of mycoplasma contamination through the detection of hydrolytic enzymes that are conserved among Mycoplasma species. Such hydrolytic enzymes include, but are not limited to, proteases, reductases and nucleases.Type: ApplicationFiled: April 28, 2010Publication date: September 2, 2010Applicant: ECI Biotech Inc.Inventor: Mitchell C. SANDERS
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Publication number: 20090304778Abstract: Described herein are substrates, methods, articles, and kits that are useful for removing interferents from samples for diagnostic purposes. The interferents are removed with phosphocellulose and cation exchange materials. These materials could also be used in vitro to improve the performance of a diagnostic assay or in vivo to remove the interferents.Type: ApplicationFiled: February 2, 2007Publication date: December 10, 2009Applicant: Ethicon, Inc.Inventors: Mitchell C. Sanders, Diane L. Ellis-Busby, Jennifer M. Havard, James C. Comolli