Abstract: A hand-held strumming device includes a hollow body, a power source, a motor, a regulator, and a strummer. The power source is disposed in the hollow body. The motor is in electrical communication with the power source. The regulator is in electrical communication with both the motor and the power source. The regulator is configured to selectively adjust a rotational speed of the motor. The strummer is rotatably disposed on the disk. The strummer is configured to be presented to strings of a stringed instrument upon rotation of the motor to strum the strings.

Abstract: A hand-held strumming device includes a hollow body, a power source, a motor, a regulator, and a strummer. The power source is disposed in the hollow body. The motor is in electrical communication with the power source. The regulator is in electrical communication with both the motor and the power source. The regulator is configured to selectively adjust a rotational speed of the motor. The strummer is rotatably disposed on the disk. The strummer is configured to be presented to strings of a stringed instrument upon rotation of the motor to strum the strings.

Abstract: The concurrent administration of chemotherapy and immunotherapy has been considered a contraindication because of the concern that the induced lymphopenia would ablate therapeutic efficacy of immunotherapy. Temozolomide has been shown to be an effective chemotherapeutic for patients with malignant gliomas and to deprive patients with glioblastoma (GBM) patients of this agent in order to treat with immunotherapy is controversial. Despite conventional dogma, we demonstrate that both chemotherapy and immunotherapy can be delivered concurrently without negating the effects of immunotherapy, in fact, the temozolomide induced lymphopenia may actually be synergistic with a peptide vaccine.