Abstract: Systems, apparatuses, and methods for performing command buffer gang submission are disclosed. A system includes at least first and second processors and a memory. The first processor (e.g., CPU) generates a command buffer and stores the command buffer in the memory. A mechanism is implemented where a granularity of work provided to the second processor (e.g., GPU) is increased which, in turn, increases the opportunities for parallel work. In gang submission mode, the user-mode driver (UMD) specifies a set of multiple queues and command buffers to execute on those multiple queues, and that work is guaranteed to execute as a single unit from the GPU operating system scheduler point of view. Using gang submission, synchronization between command buffers executing on multiple queues in the same submit is safe. This opens up optimization opportunities for application use (explicit gang submission) and for internal driver use (implicit gang submission).

Abstract: Provided herein are recombinant circular RNAs comprising at least one protein-coding nucleic acid sequence, wherein the protein-coding nucleic acid sequence encodes a reprogramming factor (e.g., a transcription factor), wherein the reprogramming factor is Oct3/4, Klf4, Sox2, Nanog, Lin28, c-Myc, or L-Myc, or a fragment or variant thereof. Also provided herein are methods of producing induced pluripotent stem cells (iPSC), the method comprising contacting a somatic cell with at least one of the recombinant circular RNAs described herein and maintaining the cell under conditions under which a reprogrammed iPSC is obtained.

Abstract: Systems, apparatuses, and methods for performing command buffer gang submission are disclosed. A system includes at least first and second processors and a memory. The first processor (e.g., CPU) generates a command buffer and stores the command buffer in the memory. A mechanism is implemented where a granularity of work provided to the second processor (e.g., GPU) is increased which, in turn, increases the opportunities for parallel work. In gang submission mode, the user-mode driver (UMD) specifies a set of multiple queues and command buffers to execute on those multiple queues, and that work is guaranteed to execute as a single unit from the GPU operating system scheduler point of view. Using gang submission, synchronization between command buffers executing on multiple queues in the same submit is safe. This opens up optimization opportunities for application use (explicit gang submission) and for internal driver use (implicit gang submission).

Abstract: Systems and methods for instantiating a network service in a network include receiving a service request for a network service; determining network resources in the network to instantiate the network service; determining a price for the network resources utilizing forecasts with adjustments to the price based on a current network status; providing the price in response to the service request; and responsive to acceptance of the price, causing instantiation of the network service through the network resources in the network.

Abstract: Systems and methods for instantiating a network service in a network include receiving a service request for a network service; determining network resources in the network to instantiate the network service; determining a price for the network resources utilizing forecasts with adjustments to the price based on a current network status; providing the price in response to the service request; and responsive to acceptance of the price, causing instantiation of the network service through the network resources in the network.

Abstract: Systems and methods are described for network service pricing and service resource management, implemented by a server communicatively coupled to a Software Defined Networking (SDN) network configured to provide the network service. The systems and methods includes receiving a service request for a network service in the SDN network; determining one or more price categories and one or more network resources for the service request, wherein the network resources are selected to instantiate the network service; adjusting a price of the network resources by adjusting the price within a range of the price categories based on current and known future network information of the SDN network; and responsive to acceptance of the price, instantiating the network service through the network resources in the SDN network.

Abstract: The arrangement and selection of digital content to present to a user can be based upon criteria such as profitability or interest to a user. The selection can also be made to ensure that a diversity of item content is presented. The selection can utilize various rules or policies for diversity at the category level or item feature level, among other such options. In addition to selection diversity, the placement of item content displayed can satisfy various diversity criteria in order to ensure diversity of display as well.

Abstract: The present invention provides compositions comprising retroviral vectors, transduced cells, and methods of using the same for gene therapy. In particular, the present invention relates to lentiviral vectors and cells transduced with those vectors to provide gene therapy to subjects having an adrenoleukodystrophy and/or adrenomyeloneuropathy.

Abstract: Systems and methods are described for network service pricing and service resource management, implemented by a server communicatively coupled to a Software Defined Networking (SDN) network configured to provide the network service. The systems and methods includes receiving a service request for a network service in the SDN network; determining one or more price categories and one or more network resources for the service request, wherein the network resources are selected to instantiate the network service; adjusting a price of the network resources by adjusting the price within a range of the price categories based on current and known future network information of the SDN network; and responsive to acceptance of the price, instantiating the network service through the network resources in the SDN network.

Abstract: The disclosure describes genetically engineered CD37 specific redirected immune effector cells expressing a chimeric antigen receptor (CAR) protein comprising an antigen binding domain derived from an antibody, a single chain antibody or portion thereof that binds CD37; a hinge region; a transmembrane domain and an intracellular signaling domain derived from human CD3? or FcR?; and optionally one or more co-stimulatory intracellular signaling domains The invention includes nucleic acids, vectors and immune effector cells associated with the production of the CAR protein, as well as methods of treating B cell malignancies in humans by cellular immunotherapy.

Abstract: The present invention provides compositions comprising retroviral vectors, transduced cells, and methods of using the same for gene therapy. In particular, the present invention relates to lentiviral vectors and cells transduced with those vectors to provide gene therapy to subjects having an adrenoleukodystrophy and/or adrenomyeloneuropathy.

Abstract: The present invention provides compositions comprising retroviral vectors, transduced cells, and methods of using the same for gene therapy. In particular, the present invention relates to lentiviral vectors and cells transduced with those vectors to provide gene therapy to subjects having an adrenoleukodystrophy and/or adrenomyeloneuropathy.

Abstract: Methods and systems are provided for encoding and decoding a video stream. Each picture in a video stream can be divided into slices, each of which contains a contiguous row of macroblocks. All the blocks corresponding to a single video component within each slice can then be used as the basis for encoding the picture. By decomposing each picture into slices, the video stream can be efficiently converted for displays of varying size and/or quality. The encoded bitstream can include a slice table to allow direct access to each slice without reading the entire bitstream. Each slice can also be processed independently, allowing for parallelized encoding and/or decoding.

Abstract: The present invention provides compositions comprising retroviral vectors, transduced cells, and methods of using the same for gene therapy. In particular, the present invention relates to lentiviral vectors and cells transduced with those vectors to provide gene therapy to subjects having an adrenoleukodystrophy and/or adrenomyeloneuropathy.

Abstract: The present invention provides compositions comprising retroviral vectors, transduced cells, and methods of using the same for gene therapy. In particular, the present invention relates to lentiviral vectors and cells transduced with those vectors to provide gene therapy to subjects having an adrenoleukodystrophy and/or adrenomyeloneuropathy.

Abstract: Methods and systems are provided for encoding and decoding a video stream. Each picture in a video stream can be divided into slices, each of which contains a contiguous row of macroblocks. All the blocks corresponding to a single video component within each slice can then be used as the basis for encoding the picture. By decomposing each picture into slices, the video stream can be efficiently converted for displays of varying size and/or quality. The encoded bitstream can include a slice table to allow direct access to each slice without reading the entire bitstream. Each slice can also be processed independently, allowing for parallelized encoding and/or decoding.

Abstract: Methods and systems are provided for encoding and decoding a video stream. Each picture in a video stream can be divided into slices, each of which contains a contiguous row of macroblocks. All the blocks corresponding to a single video component within each slice can then be used as the basis for encoding the picture. By decomposing each picture into slices, the video stream can be efficiently converted for displays of varying size and/or quality. The encoded bitstream can include a slice table to allow direct access to each slice without reading the entire bitstream. Each slice can also be processed independently, allowing for parallelized encoding and/or decoding.