Patents by Inventor Mitchell J. Weiss

Mitchell J. Weiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and Methods for Base Editing Of HBG1/2 Gene Promoter and Fetal Hemoglobin Induction
    Publication number: 20240360414
    Abstract: Systems, methods, and compositions for the introduction of mutations to the proximal promoter region of the HBG1 and HBG2 genes are provided. Also included are cells and compositions of cells bearing one or more synthetic alleles formed by the disclosed systems, methods, and compositions. This disclosure also provides a method of treating a subject by introducing the disclosed synthetic allele(s) into a cell of a subject.
    Type: Application
    Filed: January 14, 2022
    Publication date: October 31, 2024
    Inventors: Thiyagaraj MAYURANATHAN, Jonathan YEN, Mitchell J. WEISS
  • COMPOSITIONS AND METHOD FOR TREATING THALASSEMIA
    Publication number: 20230323348
    Abstract: Methods for removing excess free ?-globin in erythroid cells and treating a thalassemia using a miR-144 and/or miR-451 antagomir are described.
    Type: Application
    Filed: August 19, 2021
    Publication date: October 12, 2023
    Inventors: Mitchell J. WEISS, Christophe LECHAUVE
  • Method for treating thalassemia
    Patent number: 11298343
    Abstract: Methods for removing excess free ?-globin in erythroid cells and treating a thalassemia using an agent that activates Unc-51 Like autophagy activating Kinase (ULK) are described.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: April 12, 2022
    Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
    Inventors: Mitchell J. Weiss, Mondira Kundu, Christophe Lechauve
  • METHOD FOR TREATING THALASSEMIA
    Publication number: 20200345702
    Abstract: Methods for removing excess free ?-globin in erythroid cells and treating a thalassemia using an agent that activates Unc-51 Like autophagy activating Kinase (ULK) are described.
    Type: Application
    Filed: October 26, 2018
    Publication date: November 5, 2020
    Inventors: Mitchell J. Weiss, Mondira Kundu, Christophe Lechauve
  • Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein
    Patent number: 7642233
    Abstract: The present disclosure relates to the use of AHSP to stabilize the ? subunit of rHb. AHSP may be co-expressed with the hemoglobin genes. AHSP stabilization may be used to increase the production of intact rHb in various systems, such as E. coli, other microorganisms, or animal erythroid cells. This intact rHb may then be used as part of a blood substitute product.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: January 5, 2010
    Assignees: William Marsh Rice University, The Children's Hospital of Philadelphia
    Inventors: John S. Olson, Mitchell J. Weiss