Abstract: A cap assembly for closing an opening in a vessel may include a stopper and a rigid cap adapted to fit over the stopper and onto a vessel. The stopper may include a polymer body adapted to fit an opening of the vessel and a tubular portion defining an internal passageway extending through the polymer body. The rigid cap may include a pressure based locking mechanism adapted to engage the vessel under a unidirectional force and a tamper evident feature.

Abstract: A cap assembly for closing an opening in a vessel may include a stopper and a rigid cap adapted to fit over the stopper and onto a vessel. The stopper may include a polymer body adapted to fit an opening of the vessel and a tubular portion defining an internal passageway extending through the polymer body. The rigid cap may include a pressure based locking mechanism adapted to engage the vessel under a unidirectional force and a tamper evident feature.

Abstract: Embodiments of the present disclosure are directed to a fluid connection including a plurality of flexible polymeric tubes; an integral fluid connector coupled to and in fluid communication with each of the plurality of tubes; and a shell disposed over and encapsulating the fluid connector. The fluid connection surprisingly exhibiting significant increases in the working pressure, particularly in biopharmaceutical fluid transfer systems.

Abstract: A fluid flow sinker including a body having a generally cylindrical sidewall, a first end, a second end, and an aperture extending between the first and second ends; and a fluid passageway disposed on the first end and extending from the generally cylindrical sidewall to the aperture, wherein the fluid flow sinker is adapted to receive a tube in communication with the aperture.

Abstract: A sanitary fluid transport coupling can include a plurality of fluid conduits, each fluid conduit having a distal end and a proximal end, a support element adapted to secure a spaced relationship between the plurality of second conduits at the distal end of the plurality of fluid conduits, and an overmolded element disposed adjacent the support element. The overmolded element can form a fitting that can form a fluid connection with another fluid conduit, fluid container, or isolated environment.

Abstract: A manufacturing article adapted for use in the production of pharmaceuticals comprising a tray comprising a base having a top surface; and a manifold extending from the top surface of the base, the manifold comprising a sidewall and an upper surface, the upper surface further comprising a channel, wherein, when viewed from the top surface, the base has an area, AB, the upper surface of the manifold has an area AM, and AB>AM, and wherein the base is adapted to support a plurality of vessels each adapted to contain a fluid.

Abstract: Embodiments of the present disclosure are directed to a fluid connection including a plurality of flexible polymeric tubes; an integral fluid connector coupled to and in fluid communication with each of the plurality of tubes; and a shell disposed over and encapsulating the fluid connector. The fluid connection surprisingly exhibiting significant increases in the working pressure, particularly in biopharmaceutical fluid transfer systems.

Abstract: A manufacturing article adapted for use in the production of pharmaceuticals comprising a tray comprising a base having a top surface; and a manifold extending from the top surface of the base, the manifold comprising a sidewall and an upper surface, the upper surface further comprising a channel, wherein, when viewed from the top surface, the base has an area, AB, the upper surface of the manifold has an area AM, and AB>AM, and wherein the base is adapted to support a plurality of vessels each adapted to contain a fluid.

Abstract: A fluid flow sinker including a body having a generally cylindrical sidewall, a first end, a second end, and an aperture extending between the first and second ends; and a fluid passageway disposed on the first end and extending from the generally cylindrical sidewall to the aperture, wherein the fluid flow sinker is adapted to receive a tube in communication with the aperture.

Abstract: A flexible article includes a layer of a thermoplastic polyurethane composition including a plasticizer present at up to about 50.0% by weight of the total weight of the composition. The thermoplastic polyurethane composition has a shore A durometer of not greater than about 80. A method of making a flexible article includes combining a thermoplastic polyurethane with a plasticizer to form a thermoplastic polyurethane composition, wherein the plasticizer is present at up to about 50.0% by weight of the total weight of the composition; and forming the thermoplastic polyurethane composition into the flexible article, wherein the flexible article has a shore A durometer of not greater than about 80.

Abstract: A retainer clenches on tubing to secure a fitting and form a compression seal and connection therebetween. The retainer has first and second portions joined by a hinge and is movable from an open position to a closed position. The closed position defines an aperture in which the tubing and fitting are clenched. The retainer has a small aspect ratio with respect to the diameter and axial width of the retainer. A rib circumscribes and extends radially into the aperture to place a pre-load on the tubing to intensify a compression force of the retainer.