Patents by Inventor Mitchell Tai

Mitchell Tai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered microbes and methods for microbial oil overproduction from cellulosic materials
    Patent number: 9879248
    Abstract: The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: January 30, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Mitchell Tai
  • Engineered microbes and methods for microbial oil production
    Patent number: 9862977
    Abstract: Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: January 9, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Mitchell Tai, Sagar Chakraborty
  • ENGINEERED MICROBES AND METHODS FOR MICROBIAL OIL OVERPRODUCTION FROM CELLULOSIC MATERIALS
    Publication number: 20160186163
    Abstract: The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
    Type: Application
    Filed: August 4, 2015
    Publication date: June 30, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Mitchell Tai
  • Engineered microbes and methods for microbial oil overproduction from cellulosic materials
    Patent number: 9096876
    Abstract: The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: August 4, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Mitchell Tai
  • ENGINEERED MICROBES AND METHODS FOR MICROBIAL OIL PRODUCTION
    Publication number: 20150167034
    Abstract: Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
    Type: Application
    Filed: November 19, 2014
    Publication date: June 18, 2015
    Applicant: Massachusetts Institute of Technology
    Inventors: GREGORY STEPHANOPOULOS, MITCHELL TAI, SAGAR CHAKRABORTY
  • Engineered microbes and methods for microbial oil production
    Patent number: 8951776
    Abstract: Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: February 10, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Gregory Stephanopoulos, Mitchell Tai, Sagar Chakraborty
  • ENGINEERED MICROBES AND METHODS FOR MICROBIAL OIL OVERPRODUCTION FROM CELLULOSIC MATERIALS
    Publication number: 20130344548
    Abstract: The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
    Type: Application
    Filed: June 21, 2013
    Publication date: December 26, 2013
    Inventors: Gregory Stephanopoulos, Mitchell Tai