Patents by Inventor Mitchell W. Mutz

Mitchell W. Mutz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10112212
    Abstract: Devices and methods are provided for ejecting a droplet from a reservoir using focused acoustic radiation having a plurality of nonsimultaneous and discrete frequency ranges. Such frequency ranges may be used to control droplet volume and/or velocity. Optionally, satellite fluid ejection from the reservoir is suppressed.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: October 30, 2018
    Assignee: Labcyte Inc.
    Inventors: Richard G. Stearns, Mitchell W. Mutz, Richard N. Ellson
  • Publication number: 20180282781
    Abstract: The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.
    Type: Application
    Filed: January 12, 2018
    Publication date: October 4, 2018
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Patent number: 9920352
    Abstract: Method and system for monitoring for a change in the amount and/or concentration of a pathogen in a pathogenic fluid. The method includes providing a pathogen-impermeable enclosure enclosing the pathogenic fluid, wherein the pathogenic fluid includes a pathogen and a carrier fluid. Additionally, the method includes acoustically monitoring for a change in the amount and/or concentration of the pathogen enclosed in the pathogen-impermeable enclosure.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: March 20, 2018
    Assignee: Labcyte Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Patent number: 8453507
    Abstract: Methods are provided for analyzing characteristics of fluids in the context of an acoustic ejection system. Such a system has a controller, an acoustic radiation generator, and a coupling medium coupling the radiation to a reservoir holding fluid. The methods can use acoustic radiation to both perturb a surface of the fluid in the reservoir and analyze the effect of the perturbation. The methods may use information about prior fluids. The methods of the invention can determine physical characteristics such as speed of sound and viscosity. The methods also include ways to determine a level of acoustic energy suitable to eject a droplet. Preferably the methods are executed automatically under control of programming of a controller of an acoustic ejection system.
    Type: Grant
    Filed: January 3, 2011
    Date of Patent: June 4, 2013
    Assignee: Labcyte Inc.
    Inventors: Richard N. Ellson, Mitchell W. Mutz
  • Publication number: 20120108529
    Abstract: Compounds useful as protease inhibitors are provided, as are methods of use and preparation of such compounds and compositions containing such compounds. In one embodiment, the compounds are useful for inhibiting HIV protease enzymes, and are therefore useful in slowing the proliferation of HIV.
    Type: Application
    Filed: May 14, 2010
    Publication date: May 3, 2012
    Inventors: Robert R. Webb, II, Mitchell W. Mutz, Kenneth J. Barr
  • Publication number: 20120041019
    Abstract: Compounds useful as protease inhibitors are provided, as are methods of use and preparation of such compounds and compositions containing such compounds. In one embodiment, the compounds are useful for inhibiting HIV protease enzymes, and are therefore useful in slowing the proliferation of HIV.
    Type: Application
    Filed: December 17, 2009
    Publication date: February 16, 2012
    Inventors: Mitchell W. Mutz, Kenneth J. Barr, Jason Gestwicki
  • Publication number: 20120022040
    Abstract: Compounds useful as antimicrobials are provided, as are methods of use and preparation of such compounds and compositions containing such compounds. In one embodiment, the compounds are derivatives having a carbapenem core, and are useful for treating a microorganism infection.
    Type: Application
    Filed: December 1, 2009
    Publication date: January 26, 2012
    Inventors: Mitchell W. Mutz, Kenneth J. Barr, Gergely Makara, Ronald Alan Aungst, JR.
  • Publication number: 20120006106
    Abstract: Methods are provided for analyzing characteristics of fluids in the context of an acoustic ejection system. Such a system has a controller, an acoustic radiation generator, and a coupling medium coupling the radiation to a reservoir holding fluid. The methods can use acoustic radiation to both perturb a surface of the fluid in the reservoir and analyze the effect of the perturbation. The methods may use information about prior fluids. The methods of the invention can determine physical characteristics such as speed of sound and viscosity. The methods also include ways to determine a level of acoustic energy suitable to eject a droplet. Preferably the methods are executed automatically under control of programming of a controller of an acoustic ejection system.
    Type: Application
    Filed: January 3, 2011
    Publication date: January 12, 2012
    Applicant: LABCYTE INC.
    Inventors: Richard N. Ellson, Mitchell W. Mutz, Shehrzad Ahmed Qureshi, Richard G. Stearns
  • Patent number: 7901039
    Abstract: The present invention relates to arrays of peptidic molecules and the preparation of peptide arrays using focused acoustic energy. The arrays are prepared by acoustically ejecting peptide-containing fluid droplets from individual reservoirs towards designated sites on a substrate for attachment thereto.
    Type: Grant
    Filed: July 13, 2006
    Date of Patent: March 8, 2011
    Assignee: Picoliter Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Patent number: 7900505
    Abstract: The invention provides devices and methods for acoustically assessing the contents in a plurality of reservoirs. Each reservoir has a portion adapted to contain a fluid, and an acoustic radiation generator is positioned in acoustic coupling relationship to each of the reservoirs. Acoustic radiation generated by the acoustic radiation generator is transmitted through at least the portion of each reservoir to an analyzer. The analyzer is capable of analyzing a characteristic of the transmitted acoustic radiation and optionally correlating the characteristic to a property of the reservoirs' contents. The invention is particularly suited for assessing the contents of a plurality of reservoirs to allow for accuracy and control over the dispensing of fluids therefrom.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: March 8, 2011
    Assignee: Labcyte Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson, James K. Foote
  • Publication number: 20100284993
    Abstract: In an embodiment of the invention, a method of enhancing the efficacy of an anti-infective therapeutic agent against an obligate or facultative intracellular parasite in a host is provided. The method comprises administering to the host an effective amount of a bifunctional compound of less than about 5000 Daltons comprising the therapeutic or an active derivative, fragment or analog thereof and a protein binding moiety. The protein binding moiety binds to at least one intracellular protein. The bifunctional compound has a higher intracellular concentration as compared to the therapeutic itself in order to enhance the efficacy of the anti-infective therapeutic against the obligate or facultative intracellular parasite.
    Type: Application
    Filed: October 24, 2008
    Publication date: November 11, 2010
    Inventor: Mitchell W. Mutz
  • Publication number: 20090142391
    Abstract: A method for modulating at least one pharmacokinetic property of a drug which degrades mRNA upon administration to a host by an siRNA mechanism is provided. In a further embodiment of this invention, a bifunctional compound comprising an siRNA and a recruiter moiety are provided. The recruiter moiety may be lipophilic and may enable the siRNA to cross cell membranes and then targets an endogenous, intracellular protein to allow better distribution of the therapeutic into the cell and therefore, higher efficacy.
    Type: Application
    Filed: August 14, 2008
    Publication date: June 4, 2009
    Inventor: Mitchell W. Mutz
  • Publication number: 20090054334
    Abstract: A method is provided for improving at least one pharmacokinetic property and maintaining or improving affinity of a therapeutic upon administration to a host. In the method, one administers to the host an effective amount of a bifunctional compound of less than about 5000 Daltons comprising the therapeutic or an active derivative, fragment or analog thereof and a recruiter ligand moiety. The recruiter ligand moiety binds to at least one biomoiety. The bifunctional compound has at least one modulated pharmacokinetic property upon administration to the host and equivalent or greater affinity for a target of the therapeutic as compared to a free drug control that comprises the therapeutic. In addition, the overall drug efficacy is improved by the steric bulk of the bifunctional complexed with the recruited biomoiety.
    Type: Application
    Filed: May 23, 2008
    Publication date: February 26, 2009
    Inventors: Mitchell W. Mutz, Jason E. Gestwicki
  • Publication number: 20090053245
    Abstract: A method for modulating at least one pharmacokinetic property of an anti-angiogenic or blood disease or steroid therapeutic and efficacy upon administration to a host is provided. One administers to the host an effective amount of a bifunctional compound of less than about 5000 Daltons comprising the anti-angiogenic or blood disease or steroid therapeutic or an active derivative thereof and a pharmacokinetic modulating moiety. The pharmacokinetic modulating moiety binds to at least one intracellular protein. The bifunctional compound has at least one modulated pharmacokinetic property upon administration to the host as compared to a free drug control that comprises the anticancer therapeutic as well as enhanced efficacy not due to compound degradation. It is preferred that the pharmacokinetic modulating moiety has a mass of less than 1100 Daltons.
    Type: Application
    Filed: May 29, 2008
    Publication date: February 26, 2009
    Inventors: Mitchell W. Mutz, Andre L. Marquis
  • Patent number: 7481511
    Abstract: Devices and methods are provided for reducing the uncontrolled electrostatic charges that can alter the volume and/or trajectory of a droplet, which is typically ejected through the application of focused acoustic radiation. Also provided are reservoirs and substrates, e.g., well plates formed from a material that is at least partially nonmetallic or polymeric and either has an electrical resistivity of no more than about 1011 ohm-cm, has a surface electrical resistivity of no more than about 1012 ohm/sq, or both.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: January 27, 2009
    Assignee: Picoliter Inc.
    Inventors: Mitchell W. Mutz, David Soon-Hua Lee, George McLendon
  • Publication number: 20080306098
    Abstract: A method for modulating at least one pharmacokinetic property of a protease inhibitor upon administration to a host is provided. One administers to the host an effective amount of a bifunctional compound of less than about 5000 daltons comprising the protease inhibitor or an active derivative thereof and a pharmacokinetic modulating moiety. The pharmacokinetic modulating moiety binds to at least one intracellular protein. The bifunctional compound has at least one modulated pharmacokinetic property upon administration to the host as compared to a free drug control that comprises the protease inhibitor.
    Type: Application
    Filed: May 5, 2008
    Publication date: December 11, 2008
    Inventors: Mitchell W. Mutz, Jason E. Gestwicki
  • Publication number: 20080274538
    Abstract: The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.
    Type: Application
    Filed: July 17, 2008
    Publication date: November 6, 2008
    Applicant: Picoliter Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Patent number: 7439048
    Abstract: This invention is directed to the use of focused energy, particularly focused acoustic energy, in the spatially directed ejection of circumscribed volumes of a fluid which differ in acoustic impedance from the surrounding fluid.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: October 21, 2008
    Assignee: Picoliter, Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Patent number: 7405072
    Abstract: The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to the pathogen-containing fluid in the reservoir in a manner effective to eject a droplet of the fluid therefrom. Often, a pathogen-impermeable enclosure is used.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: July 29, 2008
    Assignee: Picoliter Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Patent number: 7405395
    Abstract: Provided is a method of transporting fluid which involves acoustic ejection into a small opening. The opening may be, for example, the inlet opening of a sample vessel. Alternatively, it may be an opening in a microfluidic device. The ejection is typically, but not necessarily carried out through the application of focused acoustic energy. The fluid being transported typically comprises a moiety of interest for analysis or further processing, which may be a biomolecule. The volumes of transported fluid may be in the nanoliter or picoliter range. Ejection may occur from very small volumes and the ejected droplet may carry away a significant fraction of the volume from which ejection occurs.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: July 29, 2008
    Assignee: Picoliter, Inc.
    Inventors: Richard N. Ellson, Mitchell W. Mutz