Abstract: Systems and methods are provided performing autonomous tuning of a stringed instrument. Images of the stringed instrument are acquired by at least two cameras and processed to identify the location of a peg. A robotic peg actuator is then engaged to actuate rotation of a peg in order to rotate the peg to a tuned angular orientation, guided by feedback generated by processing acoustic signals recorded by an acoustic transducer while a string associated with the peg is agitated. In some example implementations, the cameras and peg actuator are rigidly mounted to a frame that is configured to support the stringed instrument during peg imaging and actuation. A robotic string actuator may be provided to facilitate vibration of the string during the tuning process. Multiple robotic peg actuators may be included for per-peg rotational actuation and/or a given peg actuator may be robotically translatable to actuate more than one peg.

Abstract: Systems and methods are provided performing autonomous tuning of a stringed instrument. Images of the stringed instrument are acquired by at least two cameras and processed to identify the location of a peg. A robotic peg actuator is then engaged to actuate rotation of a peg in order to rotate the peg to a tuned angular orientation, guided by feedback generated by processing acoustic signals recorded by an acoustic transducer while a string associated with the peg is agitated. In some example implementations, the cameras and peg actuator are rigidly mounted to a frame that is configured to support the stringed instrument during peg imaging and actuation. A robotic string actuator may be provided to facilitate vibration of the string during the tuning process. Multiple robotic peg actuators may be included for per-peg rotational actuation and/or a given peg actuator may be robotically translatable to actuate more than one peg.

Abstract: The present application relates to an adaptable cell culture system that allows the application of mechanical strain to cells in culture through the displacement of a stretchable cell culture substrate. The system can apply dynamically heterogeneous strains to simulate the complex in vivo strain profiles on cultured cells, the strains including simulation of physiologic waveform such as a simulation of normal or diseased physiological biphasic stretch of the cardiac cycle, a simulation of normal or diseased physiological arterial waveform, or a cyclic mechanical strain. The system is modular and compatible with commercially available cell culture plate formats and robotic liquid handling devices. The system has a variety of applications including screening compounds for cardio toxicity or therapeutic activity, and identifying drug target, all using cell culture under the mechanical strain applied by the system.