Patents by Inventor Mitoshi Konno

Mitoshi Konno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxamic acid derivatives, the methods for preparation thereof and pharmaceutical compositions comprising thereof, as an active ingredient
    Publication number: 20040214896
    Abstract: Hydroxamic acid derivatives of the formula (I) 1
    Type: Application
    Filed: May 24, 2004
    Publication date: October 28, 2004
    Applicant: ONO PHARMACEUTICAL CO., LTD.
    Inventors: Mitoshi Konno, Katsuhito Sakaki, Masao Naka, Mikio Konishi, Tadamitsu Kishimoto
  • Hydroxamic acid derivatives, process for the production thereof and drug containing the same as the active ingredient
    Patent number: 6770644
    Abstract: Hydroxamic acid derivatives of the formula (I) (wherein all the symbols have the same meaning as defined in the specification.), non-toxic salt thereof or prodrugs thereof. The compounds of the formula (I) inhibit producing IL-6, so it may be used for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, hypergammaglobulinemia, Castleman's disease, atrial myxoma, diabetes mellitus, autoimmune diseases, hepatitis, colitis, graft versus host disease, infectious diseases and endometriosis.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: August 3, 2004
    Assignee: Ono Pharmaceuticals Co., Ltd.
    Inventors: Mitoshi Konno, Katsuhito Sakaki, Masao Naka, Mikio Konishi, Tadamitsu Kishimoto
  • Fused thiophone derivatives and drugs containing the same as the active ingredient
    Patent number: 6555555
    Abstract: The present invention relates to a fused thiophene derivative of the formula (I) (wherein all the symbols are defined as described in the specification) and an inhibitor of producing interleukin-6 and/or interleukin-12 comprising the said derivative as an active ingredient. A fused thiophene derivative of the formula (I) is useful as an agent for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, gammopathy, Castleman's disease, atrial myxoma, diabetes mellitus, autoimmune diseases, hepatitis, multiple sclerosis, colitis, graft versus host immune diseases, infectious diseases.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: April 29, 2003
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Mikio Konishi, Nobuo Katsube, Mitoshi Konno, Tadamitsu Kishimoto
  • Fused thiophone derivatives and drugs containing the same as the active ingredient
    Publication number: 20030073706
    Abstract: The present invention relates to a fused thiophene derivative of the formula (I) (wherein all the symbols are defined as described in the specification) and an inhibitor of producing interleukin-6 and/or interleukin-12 comprising the said derivative as an active ingredient.
    Type: Application
    Filed: April 23, 2002
    Publication date: April 17, 2003
    Inventors: Mikio Konishi, Nobuo Katsube, Mitoshi Konno, Tadamitsu Kishimoto
  • Fused thiophone derivatives and drugs containing the same as the active ingredient
    Patent number: 6420391
    Abstract: The present invention relates to a fused thiophene derivative of the formula (I) (wherein all the symbols are defined as described in the specification) and an inhibitor of producing interleukin-6 and/or interleukin-12 comprising the said derivative as an active ingredient. A fused thiophene derivative of the formula (I) is useful as an agent for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, gammopathy, Castleman's disease, atrial myxoma, diabetes mellitus, autoimmune diseases, hepatitis, multiple sclerosis, colitis, graft versus host immune diseases, infectious diseases.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: July 16, 2002
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Mikio Konishi, Nobuo Katsube, Mitoshi Konno, Tadamitsu Kishimoto
  • Phenylalkan(en)oic acid
    Patent number: 6001877
    Abstract: The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B.sub.4.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: December 14, 1999
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Mitoshi Konno, Takahiko Nakae, Nobuyuki Hamanaka
  • Phenylalkan(en)oic acid
    Patent number: 5795914
    Abstract: The phenylalkan(en)oic acids of the formula: ##STR1## wherein the substituents are defined in the specification.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 18, 1998
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Mitoshi Konno, Takahiko Nakae, Nobuyuki Hamanaka
  • Phenylalkan(en)oic acid
    Patent number: 5457122
    Abstract: The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, possess an antagonistic activity on leukotriene B.sub.4.
    Type: Grant
    Filed: July 13, 1993
    Date of Patent: October 10, 1995
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Mitoshi Konno, Takahiko Nakae, Nobuyuki Hamanaka
  • Phenylalkan(en)oic acid
    Patent number: 5256686
    Abstract: The phenylalkan(en)oic acids of the formula: ##STR1## as defined in the specification, possess an antagonistic activity on leukotriene B.sub.4.
    Type: Grant
    Filed: July 29, 1992
    Date of Patent: October 26, 1993
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Mitoshi Konno, Takahiko Nakae, Nobuyuki Hamanaka
  • Phenylalkan(en)oic acid
    Patent number: 5155104
    Abstract: The phenylalkan(en)oic acids of the formula: ##STR1## as defined in the specification, possess an antagonistic activity on leukotriene B.sub.4.
    Type: Grant
    Filed: September 13, 1991
    Date of Patent: October 13, 1992
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Mitoshi Konno, Takahiko Nakao, Nobuyuki Hamanaka
  • Phenylalkan(en)oic acid
    Patent number: 5086065
    Abstract: The phenylalkan(en)oic acids of the formula: ##STR1## wherein A isi) --NHCO--,ii) --O--iii) --NHSO.sub.2 --,iv) --CO--v) --CH.sub.2 -- orvi) --CH(OH)--;W isi) C1-13 alkylene,ii) phenylene oriii) ##STR2## R.sup.1 is i) hydrogen,ii) C1-4 alkyl,iii) --COOH,iv) saturated or unsaturated, 4-7 membered mono-cyclic hetero ring containing one nitrogen as a hetero atom or saturated or unsaturated, 4-7 member mono-cyclic hetero ring containing one nitrogen as a hetero atom substituted by an oxo group,v) ##STR3## vi) --CH.sub.2 OH; or A, taken together with W and R.sup.1, isi) ##STR4## ii) ##STR5## iii) --N--(SO.sub.2 R.sup.6).sub.2, iv) ##STR6## or v) ##STR7## two R.sup.2 are, same or different, i) hydrogen,ii) C1-4 alkyl oriii) 4-7 membered saturated or unsaturated, mono-cyclic hetero ring containing two or three of nitrogen and sulfur in total, or two R.sup.
    Type: Grant
    Filed: May 17, 1990
    Date of Patent: February 4, 1992
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Mitoshi Konno, Takahiko Nakae, Nobuyuki Hamanaka
  • 2-Aminomethyl phenol derivative and process for preparing thereof
    Patent number: 4254056
    Abstract: A 2-aminomethyl phenol derivative of the formula (I): ##STR1## wherein X is a halogen atom; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 which may be the same or different are each a hydrogen atom or a straight or branched chain alkyl group having 1 to 4 carbon atoms; n is 2, 3, 4 or 5 and a pharmaceutically acceptable acid addition salt thereof are disclosed. Also disclosed is a process for preparing such derivative or a pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 28, 1978
    Date of Patent: March 3, 1981
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Mitoshi Konno, Hiroyuki Itoh, Takao Tokuhiro, Katsumi Ohta, Masaki Hayashi
  • 2-Acyl-6-aminomethylphenol derivatives
    Patent number: 4245099
    Abstract: A 2-acyl-6-aminomethylphenol derivative having the formula (I): ##STR1## wherein R.sup.1 represents a straight chain or branched chain alkyl group of 1 to 6 carbon atoms unsubstituted or substituted with 1 to 3 halogen atoms; a hydrogen atom or a group having the formula (II):--C.sub.n H.sub.2n --R.sup.7 (II)wherein n represents 0 or an integer of 1 to 6; R.sup.7 represents a cycloalkyl group of 3 to 8 carbon atoms unsubstituted or substituted with at least one lower alkyl group; a phenyl group unsubstituted or substituted with at least one lower alkyl group, a halogen atom, a lower alkoxy group or a lower alkylthio group; a lower alkoxy group; a lower alkylthio group; a lower alkylsulfinyl group; a lower alkylsulfonyl group; an N-lower alkylamino group; an N,N-di-lower alkylamino group; or a pyridyl, furyl or thienyl group; R.sup.
    Type: Grant
    Filed: July 24, 1979
    Date of Patent: January 13, 1981
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Hiroyuki Itoh, Mitoshi Konno, Takao Tokuhiro, Sadahiko Iguchi, Masaki Hayashi