Abstract: A vector that includes a nucleic acid sequence encoding protelomerase, a pair of nucleic acid sequences recognized by the protelomerase, and a nucleic acid sequence located between the pair of nucleic acid sequences and encoding a protein.

Abstract: A method for preparing a modified vector and a method for modifying a vector, the methods including: binding a functional group (A) in a linker compound to a functional group in a vector, wherein the functional group (A) is capable of binding to the functional group, the linker compound includes the functional group (A) and a functional group (B), and the functional group (B) is capable of binding to a ligand compound; and binding a functional group (C) in the ligand compound to the functional group (B), wherein the functional group (C) is capable of binding to the functional group (B) and the ligand compound includes the functional group (C).

Abstract: It is an object of the present invention to provide a method for efficiently producing a B cell population comprising B cells that recognize a specific antigen. According to the present invention, provided is a method for producing a B cell population, comprising: a step (c) of culturing a cell population comprising B cells together with a specific antigen in the absence of IL-21, in the absence of IL-4, and in the presence of a cytokine other than IL-21 and IL-4, while giving stimulation mediated by CD40 and a BAFF receptor to the cells; and a step (d) of culturing the cell population comprising B cells, while giving stimulation mediated by has to the cells, so as to obtain a B cell population comprising B cells that recognize the specific antigen.

Abstract: A peptide complex including: a peptide; and a cell-membrane-permeability-imparting group introduced into the peptide, wherein the cell-membrane-permeability-imparting group includes a dendritic structure including four or more branches, and at least four branches of the four or more branches include basic functional groups at ends thereof.

Abstract: Novel cell-penetrating peptides are provided, which are excellent in cell membrane permeability. The cell-penetrating peptide or salt thereof according to the present invention is characterized in comprising the sequence represented by formula (I) or the formula (II) as follows: X-(A-B-C)l-(D)m-(Arg)n (Formula I) or X-(Arg)n-(D)m-(A-B-C)l (Formula II), wherein X is a physiologically active peptide, A, B and C are aliphatic amino acids, D is an arbitrary amino acid, l is an integer of 1 or more and 4 or less, m is an integer of 0 or more and 5 or less, when l is 1, n is an integer of 8 or more, when l is 2, n is an integer of 6 or more, when l is 3, n is an integer of 4 or more, when l is 4, n is an integer of 4 or more.

Abstract: A method for producing a transgenic cell, may include contacting, in vitro, (i) a virus comprising: a chimeric protein of an antibody-binding protein and a vesicular stomatitis virus G (VSV-G) protein; and a foreign gene, with (ii) a target cell and an antibody specific to the target cell, and/or a target cell comprising a membrane antibody, to infect the target cell with the virus.

Abstract: It is an object of the present invention to provide a method for efficiently producing a B cell population comprising B cells that recognize a specific antigen. According to the present invention, provided is a method for producing a B cell population, comprising: a step (c) of culturing a cell population comprising B cells together with a specific antigen in the absence of IL-21, in the absence of IL-4, and in the presence of a cytokine other than IL-21 and IL-4, while giving stimulation mediated by CD40 and a BAFF receptor to the cells; and a step (d) of culturing the cell population comprising B cells, while giving stimulation mediated by has to the cells, so as to obtain a B cell population comprising B cells that recognize the specific antigen.

Abstract: A method for producing a transgenic cell, may include contacting, in vitro, (i) a virus comprising: a chimeric protein of an antibody-binding protein and a vesicular stomatitis virus G (VSV-G) protein; and a foreign gene, with (ii) a target cell and an antibody specific to the target cell, and/or a target cell comprising a membrane antibody, to infect the target cell with the virus.

Abstract: A method for cultivating a plant includes applying allantoin to a plant; exposing the plant to a temperature of about 30° C. or more for at least about 60 minutes; and growing the plant in a cultivation medium.

Abstract: A method for cultivating a plant includes: applying allantoin to a grapevine; and growing the grapevine in a cultivation medium. Applying the allantoin may be performed at a veraison stage of the grapevine. Allantoin may be applied to a part of the grapevine that is above the cultivation medium at a dose of about 0.05 to 5 g per grapevine, and may be applied by spraying the allantoin on leaves or fruits of the grapevine at a dose of about 0.05 to 5 g per grapevine. The grapevine may be grown at a density of about 1,500 to 10,000 per hectare, and about 0.1 to 13 g/m2 of the allantoin may be applied.

Abstract: A method for cultivating a plant includes applying allantoin to a plant; exposing the plant to a temperature of about 30° C. or more for at least about 60 minutes; and growing the plant in a cultivation medium.

Abstract: A composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension, which comprises at least one member selected from the group consisting of a licorice hydrophobic extract, a turmeric extract, a clove extract, and a cinnamon extract.

Abstract: The present invention has for its subject to obtain a composition for preventing cancer efficient for preventing cancer or preventing cancer recurred after its therapy, or to obtain a pharmaceutical product, food and drink, and cosmetic having a function for preventing cancer. The present inventors found that a composition containing coenzyme Q has a cancer-preventive effect.

Abstract: The present invention relates to an oil/fat-containing composition for suppressing carcinogenesis, the composition including a solution produced by bringing a hydrophobic extract of licorice, which has been produced by bringing licorice into contact with an alcohol, into contact with an oil/fat. According to the present invention, there are provided an oil/fat-containing composition for prevention or treatment of the cancer, which can act through oral administration, and can be safely ingested on a day-to-day basis, pharmaceuticals and foods containing the oil/fat-containing composition.

Abstract: Provided is a method for suppressing carcinogenesis, treating cancer, or mitigating adverse reactions of anticancer agents, with low prevalence of adverse reactions by administering an effective amount of a reduced coenzyme Q as an active ingredient. In the method, the reduced coenzyme Q can be administered in the form of pharmaceuticals, cosmeceutical, cosmetics, foods such as functional foods (supplements, health aid foods, nutritional supplementary foods, nutrient-fortified foods, nutrient-adjusted foods, health beverages, foods for specified health uses, foods with nutrient function claims), animal drugs, animal feeds, or animal foods.

Abstract: An object of the present invention is to provide a peroxisome proliferator-activated receptor ? (PPAR?) ligand derived from a natural product and to provide a composition for prevention or improvement of insulin resistant syndrome, diabetes mellitus, obesity, or visceral fat obesity, characterized by comprising the ligand as an active ingredient. The present invention provides a PPAR? ligand comprising as an active ingredient, at least one compound selected from the group consisting of coumaperine and derivatives thereof. The present invention also provides a composition for prevention or improvement of insulin resistant syndrome, diabetes mellitus, obesity, or visceral fat obesity comprising the compound as an active ingredient.

Abstract: The object of the present invention is to provide PPAR? ligand derived from naturally occurring sources and a composition for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity comprising the PPAR? ligand as an active agent. The present invention relates to a ligand for peroxisome proliferator-activated receptor which comprises curcumin or its derivatives. The composition according to the present invention, which comprises the PPAR? ligand as an active agent is useful for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity.

Abstract: The invention aims at a composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension, which comprises at least one member selected from the group consisting of a licorice hydrophobic extract, a turmeric extract, a clove extract, and a cinnamon extract.

Abstract: The object of the present invention is to provide PPAR&ggr; ligand derived from naturally occurring sources and a composition for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity comprising the PPAR&ggr; ligand as an active agent.

Abstract: The invention aims at a composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension,