Abstract: A vacuum processing apparatus includes a decompressable process container; a supply port configured to supply, to the process container, an ionic liquid that absorbs an oxidizing gas; and a discharge port configured to discharge the ionic liquid supplied to the process container. A recess is provided at a joint portion between members constituting the process container. The supply port is configured to supply the ionic liquid to the recess, and the discharge port is configured to discharge the ionic liquid supplied to the recess.

Abstract: The purpose of the present invention is to provide novel complexes that improve the effect of nucleic acid medicines. Provided is a complex in which a multibranched lipid(s) binds through a linker to a strand of an oligonucleotide comprising a nucleic acid medicine having suppressing activity of the target gene expression.

Abstract: Provided are production methods capable of controlling quality of a bifurcated lipid-linked oligonucleotide, and intermediates which is useful for the production method, has good stability, and is easy to manage and analyze. Specifically, it is a method for producing a bifurcated lipid-linked oligonucleotide including a step of reacting a compound of formula (II): wherein Pro1 to Pro4 are each independently a protecting group; Pro1 and Pro2 or Pro3 and Pro4 may be taken together to form a protecting group; m, n and p are each independently an integer of 0 to 5; and Y is a group of a formula: —P(OC2H4CN)(N(i-Pr)2), or the like, with an oligonucleotide.

Abstract: The purpose of the present invention is to provide novel miR-143 derivatives described herein that can be used as oligonucleotide therapeutics.

Abstract: The purpose of the present invention is to provide double-stranded oligonucleotides comprising the CpG oligonucleotide mentioned below, as a nucleic acid derivative having an immunostimulatory activity. An adjuvant comprising a double-stranded oligonucleotide, wherein a first strand is a CpG oligonucleotide consisting of 8 to 50 nucleotides, a second strand is an oligonucleotide consisting of 8 to 60 nucleotides and comprising a sequence capable of hybridizing with the first strand, and a lipid binds to the second strand through a linker.

Abstract: The purpose of the present invention is to provide novel complexes that improve the effect of nucleic acid medicines. Provided is a complex in which a multibranched lipid(s) binds through a linker to a strand of an oligonucleotide comprising a nucleic acid medicine having suppressing activity of the target gene expression.

Abstract: The purpose of the present invention is to provide novel miR-143 derivatives described herein that can be used as oligonucleotide therapeutics.

Abstract: The purpose of the present invention is to provide double-stranded oligonucleotides comprising the CpG oligonucleotide mentioned below, as a nucleic acid derivative having an immunostimulatory activity. An adjuvant comprising a double-stranded oligonucleotide, wherein a first strand is a CpG oligonucleotide consisting of 8 to 50 nucleotides, a second strand is an oligonucleotide consisting of 8 to 60 nucleotides and comprising a sequence capable of hybridizing with the first strand, and a lipid binds to the second strand through a linker.

Abstract: In a hollow cylindrical housing which stores a coolant, a feeding device having a rotating shaft and spiral screw vanes fixedly installed on the periphery of the rotating shaft is provided. At least one first diffusion nozzle is provided in each pitch of the screw vanes on the inner wall of the housing. A pair of second diffusion nozzles are provided for every pitch of the screw vanes on the outer periphery of the rotating shaft respectively at different positions in the axial direction of the rotating shaft and at mutually opposite positions in the circumferential direction of the rotating shaft. The first diffusion nozzles are supplied with wash water through a high-temperature water piping provided on the upper outside of the housing, while the second diffusion nozzles are supplied with wash water through a channel formed in the interior of the rotating shaft.

Abstract: In a hollow cylindrical housing which stores a coolant, a feeding device having a rotating shaft and spiral screw vanes fixedly installed on the periphery of the rotating shaft is provided. At least one first diffusion nozzle is provided in each pitch of the screw vanes on the inner wall of the housing. A pair of second diffusion nozzles are provided for every pitch of the screw vanes on the outer periphery of the rotating shaft respectively at different positions in the axial direction of the rotating shaft and at mutually opposite positions in the circumferential direction of the rotating shaft. The first diffusion nozzles are supplied with wash water through a high-temperature water piping provided on the upper outside of the housing, while the second diffusion nozzles are supplied with wash water through a channel formed in the interior of the rotating shaft.

Abstract: A wing separation apparatus and method for separating wings from a breast part of poultry having its breast bone removed can handle a wide variety of poultry sizes. The breast part is supported at its left and right arm pits on a pair of shafts with the left and right arm pits positioned substantially perpendicular to the shafts. Left and right guides positioned adjacent to the shafts position the tendons at the arm pits for cutting. The guides maintain the posture of the wings and gradually applies pressure against the breast meat to position the tendons for cutting. Left and right rotary blades disposed adjacent to the guides cut the tendon near the guides, thereby separating the wings from the breast meat.

Abstract: A wing separation apparatus and method for separating wings from a breast part of poultry having its breast bone removed can handle a wide variety of poultry sizes. The breast part is supported at its left and right arm pits on a pair of shafts with the left and right arm pits positioned substantially perpendicular to the shafts. Left and right guides positioned adjacent to the shafts position the tendons at the arm pits for cutting. The guides maintain the posture of the wings and gradually applies pressure against the breast meat to position the tendons for cutting. Left and right rotary blades disposed adjacent to the guides cut the tendon near the guides, thereby separating the wings from the breast meat.

Abstract: A poultry leg boning apparatus for removing meat from the upper and lower leg bones of a poultry leg. The apparatus includes a first, cutting machine for cutting open the meat of the poultry leg along one side of the upper and lower leg bones, and a second, tendon cutting machine for removing the lower leg bone from the poultry leg. Also disclosed are methods for cutting open the meat of the poultry leg along one side of the upper and lower leg bones, and removing the meat from the lower leg bone.

Abstract: A poultry leg boning apparatus for removing meat from the upper and lower leg bones of a poultry leg. The apparatus includes a first, cutting machine for cutting open the meat of the poultry leg alone one side of the upper and lower leg bones, and a second, tendon cutting machine for removing the lower leg bone from the poultry leg. Also disclosed are methods for cutting open the meat of the poultry leg along one side of the upper and lower leg bones, and removing the meat from the lower leg bone.