Patents by Inventor Mitsuaki Yamamoto
Mitsuaki Yamamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20180113127Abstract: A problem to be solved by the invention is to provide a method of avoiding an influence of hemoglobin in an immunological measurement method for an analyte in a biological sample. The problem is solved by reacting a sample suspected of containing an analyte with an antibody binding to the analyte in the presence of a polypeptide consisting of amino acids No. 419 to No. 607 of the amino acid sequence of DnaK, a heat shock protein (HSP), derived from E. coli as set forth in SEQ ID NO: 1 or a polypeptide having at least 90% sequence identity with the polypeptide.Type: ApplicationFiled: February 25, 2016Publication date: April 26, 2018Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Koji KOBAYASHI, Takuji MATSUMOTO, Mitsuaki YAMAMOTO
-
Patent number: 9952230Abstract: A problem to be solved by the present invention is to inhibit a nonspecific agglutination reaction in an agglutination test using a monoclonal antibody having a property of specifically biding to PIVKA-II and a monoclonal antibody having a property of specifically biding to prothrombin as well as two types of carrier particles carrying these monoclonal antibodies. The nonspecific agglutination reaction can be inhibited by adding certain divalent metal ions to a reaction solution containing the monoclonal antibody having a property of specifically biding to PIVKA-II and the monoclonal antibody having a property of specifically biding to prothrombin as well as the two types of carrier particles carrying these monoclonal antibodies.Type: GrantFiled: May 23, 2012Date of Patent: April 24, 2018Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Takuji Matsumoto, Mitsuaki Yamamoto
-
Publication number: 20180088118Abstract: A problem to be solved by the invention is to provide an immunological measurement method for L-FABP in a sample using an anti-L-FABP antibody having a detection sensitivity equal to or greater than that of an existing pharmaceutical product for in-vitro diagnosis and having a favorable correlation. The problem is solved by a method of detecting L-FABP (liver-type fatty acid binding protein) in a sample with an anti-L-FABP antibody, comprising the step of bringing an anti-L-FABP antibody and a compound having a partial structure of NH2—C?N— and a cyclic structure in a molecule into contact with a sample suspected of containing L-FABP.Type: ApplicationFiled: February 25, 2016Publication date: March 29, 2018Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Koji KOBAYASHI, Takuji MATSUMOTO, Mitsuaki YAMAMOTO
-
Publication number: 20180050290Abstract: A ballast water production method is provided. The method includes a filtering step that passes raw water supplied into a housing through a filter from a primary side that is upstream of the filter to a secondary side that is downstream of the filter; a volume-increasing step after the filtering step that increases a volume of water present in a space on the secondary side of the housing while the supply of the raw water into the housing is stopped; a pressurizing step after the volume-increasing step that pressurizes an inside of the housing from the secondary side while the supply of the raw water into the housing is stopped; and a rinsing step after the pressurizing step that passes a fluid through the filter from the secondary side to the primary side while the supply of the raw water into the housing is stopped.Type: ApplicationFiled: February 3, 2016Publication date: February 22, 2018Applicant: KURARAY CO., LTD.Inventors: Mitsuaki YAMAMOTO, Kazuaki HAGIWARA, Yasuhiro TAJIMA
-
Publication number: 20180038878Abstract: A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy availability.Type: ApplicationFiled: September 29, 2017Publication date: February 8, 2018Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Mitsuaki YAMAMOTO, Shoko YAMAMOTO, Mitsuhiro NAKAMURA, Kazunori SAITO
-
Patent number: 9885707Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.Type: GrantFiled: April 1, 2013Date of Patent: February 6, 2018Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Tomo Shimizu, Keigo Kono
-
Patent number: 9880164Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.Type: GrantFiled: April 1, 2013Date of Patent: January 30, 2018Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Tomo Shimizu, Keigo Kono
-
Publication number: 20170370926Abstract: A problem of the present invention is to provide an immunochromatographic test strip avoiding agglutination of colloidal gold while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a hemagglutinating agent and the colloidal gold conjugates as a detection reagent, and to provide immunochromatography using the test strip. To solve the problem, the present inventors reviewed the composition of the existing reagent itself from a completely different viewpoint rather than the selection of type or amount of polyanions, and as a result of extensive study on each element, the inventors surprisingly found that agglutination of colloidal gold may be suppressed by using a particular additive without neutralization by polyanions.Type: ApplicationFiled: December 16, 2014Publication date: December 28, 2017Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Keigo KOHNO, Mayumi YOSHIDA, Mitsuaki YAMAMOTO, Shinya YOKOKAWA, Marie ASAMI
-
Patent number: 9733262Abstract: A method for measuring blood coagulation, including: preparing a reaction solution including a plasma specimen, a blood coagulation activator, and at least one of amino-guanidine and an acid addition salt thereof; and measuring blood coagulation time by detecting a turbidity change in the reaction solution.Type: GrantFiled: March 16, 2015Date of Patent: August 15, 2017Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Chizuru Morikawa, Remi Nakamura, Mitsuaki Yamamoto
-
Publication number: 20170102379Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.Type: ApplicationFiled: December 22, 2016Publication date: April 13, 2017Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Mayumi YOSHIDA, Mitsuaki YAMAMOTO, Shinya YOKOKAWA, Tomo SHIMIZU, Keigo KONO
-
Publication number: 20170082618Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.Type: ApplicationFiled: November 29, 2016Publication date: March 23, 2017Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Mayumi YOSHIDA, Mitsuaki YAMAMOTO, Shinya YOKOKAWA, Tomo SHIMIZU, Keigo KONO
-
Patent number: 9476891Abstract: The present invention provides an insulin-specific assay and an assay reagent capable of sensitively and specifically assaying insulin using an antibody having a property of reacting with insulin bound to an anti-insulin antibody while not reacting with insulin not bound to an anti-insulin antibody, without being affected by proinsulin and insulin analogs.Type: GrantFiled: July 21, 2010Date of Patent: October 25, 2016Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Junichi Kondou, Tomo Shimizu, Mitsuaki Yamamoto, Yasushi Nakamura
-
Publication number: 20160274092Abstract: Provided herein is a human insulin latex agglutination immunoassay and assay reagents with which nonspecific reaction in a blood sample assay can be suppressed. The assay performs an immunoreaction with anti-insulin antibody-immobilized particles in a buffer containing two or more amine compounds having a pH buffering effect.Type: ApplicationFiled: March 31, 2014Publication date: September 22, 2016Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Junichi KONDOU, Kanami NIIYAMA, Mitsuaki YAMAMOTO
-
Publication number: 20160209434Abstract: A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy availability.Type: ApplicationFiled: February 18, 2016Publication date: July 21, 2016Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Mitsuaki YAMAMOTO, Shoko YAMAMOTO, Mitsuhiro NAKAMURA, Kazunori SAITO
-
Publication number: 20160177371Abstract: A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins with an enzyme, the substrate of which is free cholesterol, optionally together with a reaction accelerator; a method for quantitating cholesterol in specific lipoproteins by using the above method; and a kit for quantitating cholesterol in specific lipoproteins to be used in the above quantification method. By using this quantification method, cholesterol in a specific fraction can be conveniently, accurately and efficiently quantitated fundamentally without resort to polyanion, etc. Thus, this method is appropriately usable in various automatic analyzers.Type: ApplicationFiled: July 20, 2015Publication date: June 23, 2016Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Mitsuhiro NAKAMURA, Yuriko TANIGUCHI, Mitsuhisa MANABE, Mitsuaki YAMAMOTO
-
Patent number: 9312669Abstract: A resistor for suppressing magnetizing inrush current includes a container made of an insulating material and at least one resistive element housed in the container, the resistive element being connected to two bushings provided at the container, the outer surface of the container being coated with a conductive paint, and the paint being connected to the ground, thereby being able to be located between a cable and a switch, and being able to fix the outer surface thereof to a ground voltage level so that human contact safety is not impaired.Type: GrantFiled: June 12, 2013Date of Patent: April 12, 2016Assignee: HITACHI, LTD.Inventors: Ayumu Morita, Naoya Okada, Akitaka Shiina, Kenji Tsuchiya, Mitsuaki Yamamoto, Hiroaki Morii, Takao Yanagisawa
-
Publication number: 20150301038Abstract: To adjust detection sensitivity and expand a measurement range depending on objects to be detected by a simple procedure in an immunoassay method involving using a colloidal metal having immobilized thereon an antibody or an antigen. Blocking treatment for a surface of a colloidal metal particle having immobilized thereon an antibody or an antigen with both components, i.e., a component of biological origin and a component of non-biological origin enables adjustment of measurement sensitivity with, for example, kinds and concentrations of both the components, and enables use of the component of non-biological origin, which has not been usable alone because of aggregation of a colloidal metal.Type: ApplicationFiled: June 29, 2012Publication date: October 22, 2015Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya Yokokawa, Mitsuaki Yamamoto, Tomo Shimizu
-
Publication number: 20150293087Abstract: Provided are: an immunoassay method in which the deviation from a theoretical value (hereinafter also referred to as “a reference value”), which may be caused when a diluted blood specimen is used as a sample, is reduced in an immunochromatographic method that is so designed that a blood specimen (whole blood, serum or plasma) is used directly as a sample without subjecting the blood specimen to any pretreatment such as a dilution treatment; and a reagent for use in the method. An immunochromatographic method performed on a blood specimen using an immunochromatographic device equipped with (1) a sample pad and (2) a membrane on which a component capable of specifically binding to an analyte is immobilized, arranged in the order of (1) and (2) from upstream, wherein hydroxyethyl starch is present in the measurement system.Type: ApplicationFiled: September 30, 2013Publication date: October 15, 2015Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Mayumi YOSHIDA, Motoki MORITA, Mitsuaki YAMAMOTO
-
Publication number: 20150185236Abstract: Provided is a reagent, which prolongs a blood coagulation time sufficiently and enhances an optical change, thereby enabling a correct and high-sensitive blood coagulability test. The present invention provides a blood coagulation time prolonging agent, including, as an active ingredient, a guanidine compound represented by the following formula (1) or an acid addition salt thereof (in the formula, R1 represents a hydrogen atom, an amino group, or an alkyl group which may have a substituent).Type: ApplicationFiled: March 16, 2015Publication date: July 2, 2015Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Chizuru MORIKAWA, Remi NAKAMURA, Mitsuaki YAMAMOTO
-
Publication number: 20150086974Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.Type: ApplicationFiled: April 1, 2013Publication date: March 26, 2015Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Tomo Shimizu, Keigo Kono