Patents by Inventor Mitsuharu Miwa
Mitsuharu Miwa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11513075Abstract: An observation device is an observation device observing an observation target and includes: an emission light source that generates emission light; a projection light source that generates projection light; a scanning mirror that scans the emission light and the projection light toward the observation target along the same optical path; a light guide optical system that guides detection target light generated in the observation target in accordance with emission of the emission light without it passing through the scanning mirror; an optical detector that detects the detection target light guided by the light guide optical system; and a control unit that controls an intensity of the projection light on the basis of a result of the detection of the detection target light.Type: GrantFiled: October 12, 2017Date of Patent: November 29, 2022Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Akira Takahashi, Shunsuke Matsuda, Takayuki Miyashita, Mitsuharu Miwa
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Publication number: 20200264187Abstract: A living body observation device is a device that allows observation of a surface of a specimen, and includes an excitation light source that radiates excitation light including a wavelength between 300 rim and 650 nm, a filter that cuts the excitation light in observation light emitted from a specimen irradiated with the excitation light, a camera that captures the observation light and outputs image data, a data storage unit that stores an image of the observation light as a reference image, an image processing unit that acquires a target image that is an image of the observation light after acquisition of the reference image and generates an analysis image indicating change in light intensity of the target image with respect to the reference image, and a display that outputs the analysis image.Type: ApplicationFiled: December 26, 2016Publication date: August 20, 2020Applicant: HAMAMATSU PHOTONICS K.K.Inventor: Mitsuharu MIWA
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Publication number: 20190376893Abstract: An observation device is an observation device observing an observation target and includes: an emission light source that generates emission light; a projection light source that generates projection light; a scanning mirror that scans the emission light and the projection light toward the observation target along the same optical path; a light guide optical system that guides detection target light generated in the observation target in accordance with emission of the emission light without it passing through the scanning mirror; an optical detector that detects the detection target light guided by the light guide optical system; and a control unit that controls an intensity of the projection light on the basis of a result of the detection of the detection target light.Type: ApplicationFiled: October 12, 2017Publication date: December 12, 2019Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Akira TAKAHASHI, Shunsuke MATSUDA, Takayuki MIYASHITA, Mitsuharu MIWA
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Publication number: 20190113455Abstract: A fluorescence observation method includes a fluorescence imaging step of imaging fluorescence from an observation target by an imaging portion. The fluorescence imaging step includes a darkening step of darkening a space between the observation target and an observation window of the imaging portion by pressing a tip end portion of a light shielding member to the observation target or a placement surface of the observation target, in a state where a base end portion of the light shielding member including a tubular main body portion is attached to the imaging portion to surround the observation window, and a focus adjustment step of adjusting a focus position of the imaging portion.Type: ApplicationFiled: March 23, 2017Publication date: April 18, 2019Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu MIWA, Takahiro SHIKAYAMA
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Patent number: 10223779Abstract: A fluorescent image acquisition system includes a light emitting device which emits excitation light during ON period and stop the emission of the excitation light during OFF period, an imaging device which outputs ON image data and OFF image data, an input device which sets a coefficient, an image processing unit which creates fluorescent image data and background image data, and an identification unit which identifies fluorescent pixels and non-fluorescent pixels. In order to create a superimposed image, the image processing unit calculates values obtained by summing pixel values of fluorescent pixels of the fluorescent image data and pixel values of fluorescent pixels of the background image data at a ratio of 1:1, as pixel values of the fluorescent pixels and calculates values obtained by multiplying at least pixel values of the non-fluorescent pixels of the background image by the coefficient, as pixel values of the non-fluorescent pixels.Type: GrantFiled: February 24, 2016Date of Patent: March 5, 2019Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Takayuki Sato, Mitsuharu Miwa, Kazumasa Hirawake
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Patent number: 10143379Abstract: A fluorescence detection device comprises: a plurality of light sources that apply an excitation light from an outside of a living body toward fluorescent dye previously injected into the living body; and a plurality of detectors that detect fluorescence emitted from the fluorescent dye by the excitation light, and output the detected fluorescence as an electric signal. The plurality of light sources and the plurality of detectors are arranged in at least one line. At least one detector is placed between two light sources, and at least one light source is placed between two detectors.Type: GrantFiled: February 18, 2013Date of Patent: December 4, 2018Assignees: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.Inventors: Naoki Unno, Yoshimasa Hattori, Mitsuharu Miwa
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Patent number: 10048206Abstract: A fluorescence viewing device is configured to take a difference between one of an image of a first frame and an image of a second frame output from an imaging device and the other of the first frame image and the second frame image stored in an image storage means, whereby clear observed images can be obtained without influence of background light. In the fluorescence viewing device, an exposure time of a fluorescence image acquisition period and an exposure time of a background image acquisition period are different from each other. Since ON/OFF durations of excitation light also become asymmetric according to the asymmetry of the exposure times, the device can reduce user's feeling of strangeness due to blinking of the excitation light.Type: GrantFiled: December 18, 2013Date of Patent: August 14, 2018Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Kazumasa Hirawake, Mitsuharu Miwa
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Patent number: 10041831Abstract: The fluorescent light phantom device 1 is provided with: a phantom support 10 having fluorescent light phantom containers 1b, 1c, 1d and 1e; and fluorescent light phantoms 12, 13, 14 and 15 which are constituted of a medium that reproduces at least one of light scattering and light absorption of an object to be measured and a fluorescent coloring matter contained in the medium of a predetermined concentration and are stored in the fluorescent light phantom containers 1b, 1c, 1d and 1e.Type: GrantFiled: October 18, 2012Date of Patent: August 7, 2018Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Kenjiro Hasegawa, Mitsuharu Miwa, Takahiro Shikayama
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Publication number: 20180082411Abstract: A fluorescent image acquisition system includes a light emitting device which emits excitation light during ON period and stop the emission of the excitation light during OFF period, an imaging device which outputs ON image data and OFF image data, an input device which sets a coefficient, an image processing unit which creates fluorescent image data and background image data, and an identification unit which identifies fluorescent pixels and non-fluorescent pixels. In order to create a superimposed image, the image processing unit calculates values obtained by summing pixel values of fluorescent pixels of the fluorescent image data and pixel values of fluorescent pixels of the background image data at a ratio of 1:1, as pixel values of the fluorescent pixels and calculates values obtained by multiplying at least pixel values of the non-fluorescent pixels of the background image by the coefficient, as pixel values of the non-fluorescent pixels.Type: ApplicationFiled: February 24, 2016Publication date: March 22, 2018Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Takayuki SATO, Mitsuharu MIWA, Kazumasa HIRAWAKE
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Publication number: 20180080877Abstract: A fluorescence image acquisition system is a system generating a fluorescence image by imaging fluorescence emitted from an observation object, the system including a light emitting device for iterating an output and stoppage of excitation light by emitting the excitation light toward the observation object during an ON period and stopping the emission of the excitation light during an OFF period, an imaging device having a light receiving unit including a plurality of pixels two-dimensionally arranged and an exposure control unit for controlling an exposure of the light receiving unit, and for outputting ON image data and OFF image data by capturing image of the observation object during each of the ON period and the OFF period, and a camera controller for generating fluorescence image data and setting an exposure time of the light receiving unit on the basis of the ON image data and the OFF image data.Type: ApplicationFiled: March 17, 2015Publication date: March 22, 2018Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Kazumasa HIRAWAKE, Mitsuharu MIWA
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Patent number: 9717806Abstract: A method of detecting an accessory cancer lesion, comprising an administration step wherein indocyanine green is administered to a living body, an irradiation step wherein a target organ suspected of having cancer is surgically exposed and irradiated with excitation light of indocyanine green, an imaging step wherein a near-infrared fluorescence intensity distribution image from the excited indocyanine green in the target organ is obtained, and an identification step wherein an area having the near-infrared fluorescence in the intensity distribution image, excluding the area detected in preoperative examination or intraoperative macroscopic observation, is identified as an accessory cancer lesion.Type: GrantFiled: December 19, 2014Date of Patent: August 1, 2017Assignees: OSAKA PREFECTURAL HOSPITAL ORGANIZATION, HAMAMATSU PHOTONICS K.K.Inventors: Osamu Ishikawa, Terumasa Yamada, Kunihito Gotoh, Mitsuharu Miwa, Takahiro Shikayama
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Publication number: 20160041098Abstract: A fluorescence viewing device is configured to take a difference between one of an image of a first frame and an image of a second frame output from an imaging device and the other of the first frame image and the second frame image stored in an image storage means, whereby clear observed images can be obtained without influence of background light. In the fluorescence viewing device, an exposure time of a fluorescence image acquisition period and an exposure time of a background image acquisition period are different from each other. Since ON/OFF durations of excitation light also become asymmetric according to the asymmetry of the exposure times, the device can reduce user's feeling of strangeness due to blinking of the excitation light.Type: ApplicationFiled: December 18, 2013Publication date: February 11, 2016Inventors: Kazumasa HIRAWAKE, Mitsuharu MIWA
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Publication number: 20150104396Abstract: A method of detecting an accessory cancer lesion, comprising an administration step wherein indocyanine green is administered to a living body, an irradiation step wherein a target organ suspected of having cancer is surgically exposed and irradiated with excitation light of indocyanine green, an imaging step wherein a near-infrared fluorescence intensity distribution image from the excited indocyanine green in the target organ is obtained, and an identification step wherein an area having the near-infrared fluorescence in the intensity distribution image, excluding the area detected in preoperative examination or intraoperative macroscopic observation, is identified as an accessory cancer lesion.Type: ApplicationFiled: December 19, 2014Publication date: April 16, 2015Inventors: Osamu Ishikawa, Terumasa Yamada, Kunihito GOTOH, Mitsuharu Miwa, Takahiro Shikayama
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Patent number: D822208Type: GrantFiled: September 14, 2016Date of Patent: July 3, 2018Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Takahiro Shikayama, Mitsuharu Miwa
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Patent number: D822209Type: GrantFiled: September 14, 2016Date of Patent: July 3, 2018Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama
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Patent number: D864395Type: GrantFiled: June 8, 2018Date of Patent: October 22, 2019Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Takahiro Shikayama, Mitsuharu Miwa
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Patent number: D874652Type: GrantFiled: June 4, 2018Date of Patent: February 4, 2020Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama
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Patent number: D879962Type: GrantFiled: June 4, 2018Date of Patent: March 31, 2020Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama
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Patent number: D880698Type: GrantFiled: June 4, 2018Date of Patent: April 7, 2020Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama
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Patent number: D919813Type: GrantFiled: March 6, 2020Date of Patent: May 18, 2021Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Mitsuharu Miwa, Takahiro Shikayama