Abstract: The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, spinocerebellar degeneration (e.g., dentatorubural pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract: The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, spinocerebellar degeneration (e.g., dentatorubural pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract: An endoscope system includes: a position and posture calculating portion that estimates a position of a distal end and a longitudinal direction of a distal end portion; a condition determining portion that, based on the shape information at the position of the distal end that is estimated, determines whether or not an angle that a core line direction of the luminal organ and the longitudinal direction estimated by the position and posture calculating portion form is equal to or less than a predetermined threshold value; and a position and posture information recording portion that, when the angle that the core line direction and the longitudinal direction form is equal to or less than the predetermined threshold value, records information regarding the position and the longitudinal direction of the distal end.

Abstract: An endoscope system includes: an image storage section that stores image information associated with position information of a luminal organ of a subject; a virtual endoscopic image generating section that generates a virtual endoscopic image endoscopically depicted; an image pickup section that picks up an image in the luminal organ; a position registration processing section that compares the virtual endoscopic image and an endoscopic image, and extracts an virtual endoscopic image similar to the endoscopic image; a position estimation section that estimates a distal end position of an endoscope insertion portion; a feature region determination section that determines whether or not the distal end position exists in a feature region; a storage section that stores information for presentation; and a candidate information presentation control section that presents the virtual endoscopic image based on the information in the storage section, to a display section as candidate information.

Abstract: In an image forming apparatus including an apparatus body, an image forming portion, a conveyance unit, a storage portion, a sheet movement unit, a memory portion, and a control portion, in a case where an image forming instruction to perform image formation on a sheet has been received, the control portion provides notification of a plurality of discharging methods of storing the sheet which is an object of the image forming instruction, into the storage portion and then exposing the sheet outside of the apparatus body via an opening of the storage portion, based on first information stored in the memory portion and second information about the sheet which is an object of the image forming instruction, and controls the conveyance unit and the sheet movement unit based on a discharging method selected from among the plurality of discharging methods.

Abstract: The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down's syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, spinocerebellar degeneration (e.g., dentatorubural pallidoluysian atrophy) and Huntington's disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract: An endoscope system includes an endoscope including an image pickup section that picks up an image of a subject lumen organ, a recording section that records three-dimensional image information of a lumen organ acquired from a medical diagnosis apparatus, a position estimating section that estimates a distal end position of the endoscope, a lumen-diameter acquiring section that acquires a lumen diameter of the organ in the estimated position of the distal end, a condition determining section that determines whether the acquired lumen diameter is smaller than the reference lumen diameter, an image-change-amount detecting section that detects a change amount of a predetermined parameter in an endoscopic image picked up by the image pickup section, a virtual-endoscopic-image generating section that generates a virtual endoscopic image from any visual point position, and an information recording section that records a position of a distal end of an insertion section and the virtual endoscopic image.

Abstract: The present invention provides a compound having a lysine specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, Alzheimer's disease, Parkinson's disease or Huntington's disease, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); B is a benzene ring optionally having further substituent(s); R1, R2 and R3 are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); A and R1 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s); and R2 and R3 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s), or a salt thereof.

Abstract: A honeycomb structure has a plurality of pillar honeycomb segments with a porous partition wall that defines a plurality of cells extending from an inflow end face as one end face to an outflow end face as another end face and becoming channels for a fluid and a bonding layer that bonds side surfaces of the plurality of honeycomb segments one another, the bonding layer contains a plurality of plate-shaped particles, the plate-shaped particles are laminated in a thickness direction X of the bonding layer at a cross section of the bonding layer cut off to the thickness direction of the bonding layer, the number of particles ? meets Expression: number of particles ?>10, and the number of particles ? and the number of particles ? meet a relationship of Expression: (number of particles ?/number of particles ?)>3.

Abstract: There is provided a honeycomb structure where a crack at honeycomb segments, which constitute a honeycomb bonded assembly, is reduced. A honeycomb structure has a pillar-shaped honeycomb bonded assembly that has a plurality of pillar-shaped honeycomb segments having a porous partition wall defining a plurality of cells extending from an inflow end face as one end face to an outflow end face as another end face and becoming channels for a fluid, and a bonding layer bonding side surfaces of the plurality of honeycomb segments, and in the honeycomb bonded assembly, at 25 to 800° C., a thermal expansion coefficient of the bonding layer is larger than a thermal expansion coefficient of the honeycomb segment.

Abstract: There is provided a honeycomb structure where a crack at a honeycomb substrate is reduced. A honeycomb structure has a honeycomb substrate that has a porous partition wall defining a plurality of cells extending from an inflow end face as one end face to an outflow end face as another end face and becoming channels for a fluid, and an outer circumference coating layer disposed at an outer circumference of the honeycomb substrate . At 25 to 800° C., a thermal expansion coefficient of the outer circumference coating layer is larger than a thermal expansion coefficient of the honeycomb substrate. The thermal expansion coefficients of the outer circumference coating layer and the thermal expansion coefficient at 25 to 800° C. preferably meet a relationship represented by the expression: 1.1<(the thermal expansion coefficient of the outer circumference coating layer/the thermal expansion coefficient of the honeycomb substrate)<40.

Abstract: An endoscope system includes: a light transmitting section for transmitting illuminating light and emit the light from a light exit surface; a light receiving section for receiving return light of the light emitted from the light exit surface; a light guiding section for allowing the light to be incident on the light receiving section by totally reflecting return light from a subject or the emitted light at least one or more times; a driving section for allowing an end portion having the light exit surface of the light transmitting section to be swung; a light detecting section for detecting the light received through the light guiding section, as a signal; and a control section for, if the pattern of fluctuations in the signal level by the light detected by the light detected section does not correspond to the predetermined pattern of fluctuations, performing control for lowering a quantity of the illuminating light.

Abstract: An endoscope system includes: a position and posture calculating portion that estimates a position of a distal end and a longitudinal direction of a distal end portion; a condition determining portion that, based on the shape information at the position of the distal end that is estimated, determines whether or not an angle that a core line direction of the luminal organ and the longitudinal direction estimated by the position and posture calculating portion form is equal to or less than a predetermined threshold value; and a position and posture information recording portion that, when the angle that the core line direction and the longitudinal direction form is equal to or less than the predetermined threshold value, records information regarding the position and the longitudinal direction of the distal end.

Abstract: A rotary self-propelled endoscope system includes an insertion section body, an insertion section, a drive unit, a torque detection unit, and a control unit. In a distal end portion of the insertion section body, a rigid distal end portion including an image pickup apparatus is disposed. The insertion section is rotatably fit to the outside of the insertion section body, and includes a rotary tubular member having a helical portion formed by a helical concave-convex portion. The drive unit applies the rotary tubular member with axial and rotational drive force. The torque detection unit detects torque information of the rotary tubular member. On the basis of the torque information detected by the torque detection unit, the control unit compares a present value with a preset limit value for controlling the torque of the rotary tubular member, and controls the drive unit on the basis of the comparison result.

Abstract: A sheet interval, serving as the distance between conveyed recording materials, is properly controlled based on a kind of a recording material and any one of a printing ratio, an adhesion amount of toner, and the presence or absence of graphic data, thus allowing printing at throughput suitable for, for example, the kind of the recording material and the printing ratio without changing an image forming condition such that image quality does not vary.

Abstract: An endoscope system includes: an image storage section that stores image information associated with position information of a luminal organ of a subject; a virtual endoscopic image generating section that generates a virtual endoscopic image endoscopically depicted; an image pickup section that picks up an image in the luminal organ; a position registration processing section that compares the virtual endoscopic image and an endoscopic image, and extracts an virtual endoscopic image similar to the endoscopic image; a position estimation section that estimates a distal end position of an endoscope insertion portion; a feature region determination section that determines whether or not the distal end position exists in a feature region; a storage section that stores information for presentation; and a candidate information presentation control section that presents the virtual endoscopic image based on the information in the storage section, to a display section as candidate information.

Abstract: An endoscope system includes: a virtual endoscopic image generating section that generates a virtual endoscopic image; an image pickup section picking up an image of an inside of the lumen; a position information obtaining section that obtains information on a position of a distal end of an insertion portion of an endoscope; a distance calculating section that calculates a distance from the obtained position of the distal end of the insertion portion to a feature region; a distance comparing section that determines whether or not the calculated distance is within a set distance via comparison; a variation amount detecting section that detects a variation amount of a feature of a structure of an organ in the picked-up endoscopic image; and an information recording section that records the position of the distal end of the insertion portion based on a result of the comparison by the distance comparing section.

Abstract: An endoscope apparatus includes: a laser light source that generates laser light; an optical fiber that guides laser light inputted to a proximal end and applies the laser light to a subject from a distal end; an actuator swinging a distal end portion of the optical fiber; the conductive wire provided in close contact with the optical fiber, and connected to the actuator; a signal generator that generates a drive signal for driving the actuator, the drive signal being conducted by the conductive wire; a detection circuit that detects a current flowing in the conductive wire when the signal generator generates the drive signal, and detects that the conductive wire is broken, based on the detected current value; and a controller that controls an amount of illuminating light based on a result of determination of whether or not the conductive wire is broken in the detection circuit.

Abstract: An endoscope system includes: a light transmitting section for transmitting illuminating light and emit the light from a light exit surface; a light receiving section for receiving return light of the light emitted from the light exit surface; a light guiding section for allowing the light to be incident on the light receiving section by totally reflecting return light from a subject or the emitted light at least one or more times; a driving section for allowing an end portion having the light exit surface of the light transmitting section to be swung; a light detecting section for detecting the light received through the light guiding section, as a signal; and a control section for, if the pattern of fluctuations in the signal level by the light detected by the light detected section does not correspond to the predetermined pattern of fluctuations, performing control for lowering a quantity of the illuminating light.

Abstract: The main body of the image forming system includes an image forming apparatus; an optional apparatus; and a communication unit configured to perform communication between the main body of the image forming apparatus and the optional apparatus. The optional apparatus includes one optional control unit for controlling multiple optional functions, and the main body of the image forming apparatus includes a registration designation unit configured to designate registration of an ID number to the one optional control unit of the optional apparatus by the communication unit to designate registration of an ID number to the one optional control unit of the optional apparatus. The one optional control unit assigns an ID number to each of the multiple optional functions according to the designation from the main body of the image forming apparatus.