Patents by Inventor Mitsuhisa Yamano
Mitsuhisa Yamano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10336864Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (?-PGA-PAE) of poly(?-glutamic acid) (?-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.Type: GrantFiled: October 9, 2017Date of Patent: July 2, 2019Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Mitsuhisa Yamano, Toshiaki Nagata, Hideki Saitoh
-
Publication number: 20180079741Abstract: The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative. The optically active piperidine-3-carboxamide or a derivative thereof, which is obtained by subjecting 1,4,5,6-tetrahydropyridine-3-carboxamide or a derivative thereof to an asymmetric reduction in the presence of a catalyst, is used as an intermediate.Type: ApplicationFiled: October 18, 2017Publication date: March 22, 2018Applicant: Takeda Pharmaceuticals Company LimitedInventors: Masatoshi Yamada, Sayuri Hirano, Ryoji Tsuruoka, Mitsuhisa Yamano
-
Publication number: 20180044472Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (?-PGA-PAE) of poly(?-glutamic acid) (?-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.Type: ApplicationFiled: October 9, 2017Publication date: February 15, 2018Inventors: Mitsuhisa YAMANO, Toshiaki NAGATA, Hideki SAITOH
-
Patent number: 9815938Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (?-PGA-PAE) of poly(?-glutamic acid) (?-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.Type: GrantFiled: June 25, 2014Date of Patent: November 14, 2017Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Mitsuhisa Yamano, Toshiaki Nagata, Hideki Saitoh
-
Patent number: 9809569Abstract: The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo -1,2,3,4-tetrahydropyrimidine derivative. The optically active piperidine-3-carboxamide or a derivative thereof, which is obtained by subjecting 1,4,5,6-tetrahydropyridine -3-carboxamide or a derivative thereof to an asymmetric reduction in the presence of a catalyst, is used as an intermediate.Type: GrantFiled: March 13, 2015Date of Patent: November 7, 2017Assignee: Takeda Pharmaceutical Company LimitedInventors: Masatoshi Yamada, Sayuri Hirano, Ryoji Tsuruoka, Mitsuhisa Yamano
-
Publication number: 20170081305Abstract: The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative. The optically active piperidine-3-carboxamide or a derivative thereof, which is obtained by subjecting 1,4,5,6-tetrahydropyridine-3-carboxamide or a derivative thereof to an asymmetric reduction in the presence of a catalyst, is used as an intermediate.Type: ApplicationFiled: March 13, 2015Publication date: March 23, 2017Applicant: Takeda Pharmaceutical Company LimitedInventors: Masatoshi Yamada, Sayuri HIRANO, Ryoji TSURUOKA, Mitsuhisa YAMANO
-
Publication number: 20160177032Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (?-PGA-PAE) of poly(?-glutamic acid) (?-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.Type: ApplicationFiled: June 25, 2014Publication date: June 23, 2016Inventors: Mitsuhisa YAMANO, Toshiaki NAGATA, Hideki SAITOH
-
Patent number: 9238667Abstract: [Problem] Provision of a superior rhodium catalyst and a production method of amine compound.Type: GrantFiled: March 28, 2013Date of Patent: January 19, 2016Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Mitsuhisa Yamano, Masatoshi Yamada, Hirotsugu Usutani
-
Patent number: 8981147Abstract: The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions. A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).Type: GrantFiled: February 19, 2014Date of Patent: March 17, 2015Assignee: Takeda Pharmaceutical Company LimitedInventors: Mitsuhisa Yamano, Mitsutaka Goto, Shinji Kawaguchi, Masatoshi Yamada, Jun-ichi Kawakami
-
Publication number: 20150051416Abstract: [Problem] Provision of a superior rhodium catalyst and a production method of amine compound.Type: ApplicationFiled: March 28, 2013Publication date: February 19, 2015Inventors: Mitsuhisa Yamano, Masatoshi Yamada, Hirotsugu Usutani
-
Patent number: 8952185Abstract: Provided is a production method of an optically active dihydrobenzofuran derivative. A production method of an optically active form of a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof and the like.Type: GrantFiled: February 16, 2012Date of Patent: February 10, 2015Assignee: Takeda Pharmaceutical Company LimitedInventors: Mitsuhisa Yamano, Mitsutaka Goto, Takahiro Konishi
-
Publication number: 20140171655Abstract: The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions. A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).Type: ApplicationFiled: February 19, 2014Publication date: June 19, 2014Applicant: Takeda Pharmaceutical Company LimitedInventors: Mitsuhisa YAMANO, Mitsutaka GOTO, Shinji KAWAGUCHI, Masatoshi YAMADA, Jun-ichi KAWAKAMI
-
Patent number: 8691718Abstract: The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions. A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).Type: GrantFiled: September 20, 2006Date of Patent: April 8, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Mitsuhisa Yamano, Mitsutaka Goto, Shinji Kawaguchi, Masatoshi Yamada, Jun-ichi Kawakami
-
Publication number: 20130345444Abstract: Provided is a production method of an optically active dihydrobenzofuran derivative. A production method of an optically active form of a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof and the like.Type: ApplicationFiled: February 16, 2012Publication date: December 26, 2013Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Mitsuhisa Yamano, Mitsutaka Goto, Takeshi Kajiwara, Hiroyuki Maeda, Takahiro Konishi, Misayo Sera, Yuichiro Kondo, Seiji Yamasaki
-
Patent number: 8373007Abstract: Disclosed is a vinamidinium salt represented by the formula (I): [wherein R1 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or the like; R2 and R3 are the same or different and each represents a lower alkyl group, or alternatively R2 and R3 may combine together to form a ring; R4 and R5 are the same or different and each represents a lower alkyl group, or alternatively R4 and R5 may combine together to form a ring; X and Y are the same or different and each represents a bromine atom or a chlorine atom; n represents a number of not less than 2; and m represents 0 or n], and methods for synthesizing a heterocyclic ring compound using the salt.Type: GrantFiled: March 27, 2009Date of Patent: February 12, 2013Assignee: Takeda Pharmaceutical Company Ltd.Inventors: Mitsuhisa Yamano, Yasuhiro Sawai, Masahiro Mizuno
-
Patent number: 8053604Abstract: A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.Type: GrantFiled: January 27, 2010Date of Patent: November 8, 2011Assignee: Takeda Pharmaceutical Company LimitedInventors: Mitsutaka Goto, Mitsuhisa Yamano
-
Publication number: 20110015399Abstract: Disclosed is a vinamidinium salt represented by the formula (I): [wherein R1 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or the like; R2 and R3 are the same or different and each represents a lower alkyl group, or alternatively R2 and R3 may combine together to form a ring; R4 and R5 are the same or different and each represents a lower alkyl group, or alternatively R4 and R5 may combine together to form a ring; X and Y are the same or different and each represents a bromine atom or a chlorine atom; n represents a number of not less than 2; and m represents 0 or n], which can be used as a general purpose reagent useful for synthesis of various nitrogen-containing heteroaromatic rings having a substituent. The vinamidinium salt has excellent storage stability and reaction selectivity. A method for synthesizing a nitrogen-containing heteroaromatic ring compound using the vinamidinium salt is also disclosed.Type: ApplicationFiled: March 27, 2009Publication date: January 20, 2011Applicant: TAKEDA PHARMACEUTICAL COMPANY LTD.Inventors: Mitsuhisa Yamano, Yasuhiro Sawai, Masahiro Mizuno
-
Publication number: 20100125153Abstract: A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.Type: ApplicationFiled: January 27, 2010Publication date: May 20, 2010Inventors: Mitsutaka Goto, Mitsuhisa Yamano
-
Patent number: 7678942Abstract: A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.Type: GrantFiled: March 6, 2007Date of Patent: March 16, 2010Assignee: Takeda Pharmaceutical Company LimitedInventors: Mitsutaka Goto, Mitsuhisa Yamano
-
Publication number: 20090270635Abstract: The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions. A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).Type: ApplicationFiled: September 20, 2006Publication date: October 29, 2009Inventors: Mitsuhisa Yamano, Mitsutaka Goto, Shinji Kawaguchi, Masatoshi Yamada, Jun-ichi Kawakami