Patents by Inventor Mitsuji Akazawa
Mitsuji Akazawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220040121Abstract: The objective of the present invention is to provide a local anesthetic agent-containing patch having a skin permeability, cohesion force and adhesive property practical as a pharmaceutical product. The patch of the present invention is characterized in comprising a backing layer, and an adhesive layer on the backing layer, wherein the adhesive layer comprises at least a local anesthetic agent, a thermoplastic elastomer, a higher fatty acid ester, and a polyol fatty acid monoester, and a ratio of the higher fatty acid ester to 100 mass parts of the thermoplastic elastomer is 25 mass parts or more and 200 mass parts or less.Type: ApplicationFiled: February 27, 2020Publication date: February 10, 2022Applicant: KANEKA CORPORATIONInventors: Hiroyuki OGINO, Mitsuji AKAZAWA, Masaoki GOTO
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Publication number: 20210260196Abstract: It is an object of the present invention to provide a formulation comprising ethyl cellulose, an active pharmaceutical ingredient, and a solvent, which is a stable formulation in which generation of impurities is suppressed even during the long-term storage. According to the present invention, provided is a formulation comprising (a) an active pharmaceutical ingredient, (b) ethyl cellulose, (c) 2-mercaptobenzimidazole, and (d) 0.1 part by weight or more of solvent with respect to 1 part by weight of the ethyl cellulose.Type: ApplicationFiled: June 13, 2019Publication date: August 26, 2021Applicant: KANEKA CORPORATIONInventors: Masaya MIZUTANI, Mitsuji AKAZAWA, Tatsuyoshi TANAKA, Hiroyuki OGINO
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Publication number: 20210062053Abstract: It is an object of the present invention to provide an adhesive sheet for skin patch, having adhesive force and cohesive force that are practicable as a pharmaceutical product and exhibiting high drug solubility and sufficient drug skin permeability. According to the present invention, provided is an adhesive sheet for skin patch, having an adhesive layer on a support, wherein the adhesive layer comprises, at least, a thermoplastic elastomer and a long-chain branched alcohol having a total carbon number of 13 or more, the long-chain branched alcohol is comprised in an amount of 40 parts by weight or more and 200 parts by weight or less, with respect to 100 parts by weight of the thermoplastic elastomer, and the adhesive layer does not comprise a tackifier, or comprises a tackifier in an amount of 30% by weight or less, with respect to the amount of the entire adhesive layer.Type: ApplicationFiled: January 22, 2019Publication date: March 4, 2021Applicant: KANEKA CORPORATIONInventors: Hiroyuki OGINO, Mitsuji AKAZAWA, Masaoki GOTOU, Masaya MIZUTANI, Tatsuyoshi TANAKA
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Patent number: 10758494Abstract: The present invention provides a patch containing an adhesive layer maintaining a drug, which is formed on a support, wherein the aforementioned adhesive layer comprises a thermoplastic elastomer, a non-volatile hydrocarbon oil in an amount exceeding 50 parts by weight and not more than 800 parts by weight per 100 parts by weight of the elastomer, and rivastigmine or a salt thereof, and the aforementioned adhesive layer optionally further contains a tackifier at a content in the adhesive layer of not more than 10 wt %.Type: GrantFiled: June 12, 2013Date of Patent: September 1, 2020Assignee: KM Transderm Ltd.Inventors: Hiroyuki Ogino, Masaoki Goto, Atsuyo Hamada, Mitsuji Akazawa, Sadao Yukimoto
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Publication number: 20200214991Abstract: Provided is an adhesive sheet for adhesion to the skin, which has sufficient adhesiveness and causes low skin irritation. The adhesive sheet comprises a support and an adhesive layer formed on the support, in which the adhesive layer contains at least a thermoplastic elastomer and a non-volatile hydrocarbon oil. Further provided is a transdermal absorption preparation having sufficient adhesiveness and drug releaseability and causes low skin irritation. The transdermal absorption preparation comprises an adhesive sheet as described herein and a drug or a pharmaceutically acceptable salt thereof that is contained in the adhesive layer of the sheet.Type: ApplicationFiled: March 16, 2020Publication date: July 9, 2020Applicant: KM Transderm Ltd.Inventors: Hiroyuki OGINO, Sadao YUKIMOTO, Atsuyo HAMADA, Mitsuji AKAZAWA, Masaoki GOTO
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Publication number: 20200078347Abstract: It is an object of the present invention to provide an efinaconazole-containing film-forming preparation, which has no sticky surface after solidification thereof, has sufficient cohesiveness after solidification thereof, and is easily peeled without washing. The present invention provides a therapeutic preparation for onychomycosis, comprising efinaconazole or a salt thereof, 1% by weight or more and 30% by weight or less of ethyl cellulose, 20% by weight or more of a volatile solvent (wherein the volatile solvent is water or a liquid component having a boiling point lower than that of water), and 0.01% by weight or more and less than 30% by weight of a surfactant.Type: ApplicationFiled: December 15, 2017Publication date: March 12, 2020Applicant: KANEKA CORPORATIONInventors: Masaya MIZUTANI, Tatsuyoshi TANAKA, Hiroyuki OGINO, Mitsuji AKAZAWA
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Patent number: 10525014Abstract: It is an object of the present invention to provide a patch having practical adhesive force and cohesive force as a pharmaceutical product, and also exhibiting a fast-acting anesthetic action. The present invention provides a patch formed from an adhesive layer comprising 5% by weight or more and less than 20% by weight of a mixture of lidocaine and another local anesthetic, wherein the adhesive layer comprises at least a rubber-based pressure-sensitive adhesive and liquid paraffin and a content of a tackifier in the adhesive layer is 10% by weight or less.Type: GrantFiled: August 5, 2016Date of Patent: January 7, 2020Assignee: KANEKA CORPORATIONInventors: Tatsuyoshi Tanaka, Masaya Mizutani, Hiroyuki Ogino, Mitsuji Akazawa, Akio Fujii, Naohiro Imai
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Patent number: 10314791Abstract: The invention provides an adhesive sheet for skin, which shows sufficient adhesiveness to the skin and causes low skin irritation. The adhesive sheet contains an adhesive layer formed on a support, in which the adhesive layer contains at least a thermoplastic elastomer, a non-volatile hydrocarbon oil, and polyisobutylene, but no tackifier. The polyisobutylene is a medium molecular weight polyisobutylene with a viscosity average molecular weight of more than 100,000 and not more than 500,000. The invention also provides a percutaneous absorption preparation containing a drug or a pharmaceutically acceptable salt thereof in an adhesive layer of the inventive adhesive sheet for skin.Type: GrantFiled: December 4, 2015Date of Patent: June 11, 2019Assignee: KM Transderm Ltd.Inventors: Hiroyuki Ogino, Sadao Yukimoto, Atsuyo Hamada, Mitsuji Akazawa, Masaoki Goto
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Publication number: 20190167602Abstract: The present invention provides transdermal absorption preparation having a support, and a drug-containing adhesive layer formed on the support, wherein a drug-containing adhesive layer contains donepezil or a salt thereof, and a higher fatty acid salt.Type: ApplicationFiled: January 24, 2019Publication date: June 6, 2019Applicant: KM Transderm Ltd.Inventors: Atsuyo HAMADA, Mitsuji AKAZAWA, Keiko YAMASAKI, Masaoki GOTO
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Patent number: 10098858Abstract: An aqueous loxoprofen-containing patch is provided, which has good stability and excellent transdermal absorption of loxoprofen. The aqueous patch includes loxoprofen or a salt thereof and triacetin. Specifically, the aqueous patch includes, based on the weight of the adhesive gel base, 0.1 to 5% by weight of loxoprofen or a salt thereof, 0.5 to 5% by weight of triacetin, 1 to 30% by weight of a water-soluble polymer, 0.01 to 5% by weight of a cross-linking agent, 10 to 90% by weight of purified water, and 0 to 20% by weight of an inorganic powder.Type: GrantFiled: December 11, 2008Date of Patent: October 16, 2018Assignee: Teikoku Seiyaku Co., Ltd.Inventors: Kazuha Tani, Mitsuji Akazawa
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Publication number: 20180235902Abstract: It is an object of the present invention to provide a patch having practical adhesive force and cohesive force as a pharmaceutical product, and also exhibiting a fast-acting anesthetic action. The present invention provides a patch formed from an adhesive layer comprising 5% by weight or more and less than 20% by weight of a mixture of lidocaine and another local anesthetic, wherein the adhesive layer comprises at least a rubber-based pressure-sensitive adhesive and liquid paraffin and a content of a tackifier in the adhesive layer is 10% by weight or less.Type: ApplicationFiled: August 5, 2016Publication date: August 23, 2018Applicant: KANEKA CORPORATIONInventors: Tatsuyoshi TANAKA, Masaya MIZUTANI, Hiroyuki OGINO, Mitsuji AKAZAWA, Akio FUJII, Naohiro IMAI
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Transdermal patch with different viscosity hydrocarbon oils in the drug layer and the adhesive layer
Patent number: 9895320Abstract: A patch containing a storage layer retaining a drug or a pharmaceutically acceptable salt thereof and an adhesive layer which are formed on a support, wherein the adhesive layer contains a thermoplastic elastomer, and a non-volatile hydrocarbon oil in more than 50 parts by weight and not more than 800 parts by weight per 100 parts by weight of the elastomer, and the adhesive layer optionally further contains a tackifier at a content of not more than 10 wt %.Type: GrantFiled: September 28, 2013Date of Patent: February 20, 2018Assignee: KM Transderm Ltd.Inventors: Hiroyuki Ogino, Masaoki Goto, Atsuyo Hamada, Mitsuji Akazawa, Sadao Yukimoto -
Publication number: 20170367994Abstract: The present invention provides transdermal absorption preparation having a support, and a drug-containing adhesive layer formed on the support, wherein a drug-containing adhesive layer contains donepezil or a salt thereof, and a higher fatty acid salt.Type: ApplicationFiled: September 11, 2017Publication date: December 28, 2017Applicant: KM Transderm Ltd.Inventors: Atsuyo HAMADA, Mitsuji AKAZAWA, Keiko YAMASAKI, Masaoki GOTO
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Publication number: 20170333367Abstract: The present invention provides an adhesive sheet for skin, which shows sufficient adhesiveness to the skin and causes low skin irritation. The first adhesive sheet for skin of the present invention has an adhesive layer formed on a support, wherein the aforementioned adhesive layer contains at least a thermoplastic elastomer, non-volatile hydrocarbon oil and polyisobutylene having a viscosity average molecular weight of more than 100,000 and not more than 500,000, and does not contain a tackifier.Type: ApplicationFiled: December 4, 2015Publication date: November 23, 2017Applicant: KM Transderm Ltd.Inventors: Hiroyuki OGINO, Sadao YUKIMOTO, Atsuyo HAMADA, Mitsuji AKAZAWA, Masaoki GOTO
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Publication number: 20160250156Abstract: The present invention provides transdermal absorption preparation having a support, and a drug-containing adhesive layer formed on the support, wherein a drug-containing adhesive layer contains donepezil or a salt thereof, and a higher fatty acid salt.Type: ApplicationFiled: May 4, 2016Publication date: September 1, 2016Applicant: KM Transderm Ltd.Inventors: Atsuyo HAMADA, Mitsuji AKAZAWA, Keiko YAMASAKI, Masaoki GOTO
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Publication number: 20160206568Abstract: Provided is an adhesive sheet for adhesion to the skin, which has sufficient adhesiveness and causes low skin irritation. The adhesive sheet comprises a support and an adhesive layer formed on the support, in which the adhesive layer contains at least a thermoplastic elastomer and a non-volatile hydrocarbon oil. Further provided is a transdermal absorption preparation having sufficient adhesiveness and drug releaseability and causes low skin irritation. The transdermal absorption preparation comprises an adhesive sheet as described herein and a drug or a pharmaceutically acceptable salt thereof that is contained in the adhesive layer of the sheet.Type: ApplicationFiled: June 12, 2014Publication date: July 21, 2016Inventors: Hiroyuki OGINO, Sadao YUKIMOTO, Atsuyo HAMADA, Mitsuji AKAZAWA, Masaoki GOTO
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Publication number: 20150374642Abstract: A patch containing a storage layer retaining a drug or a pharmaceutically acceptable salt thereof and an adhesive layer which are formed on a support, wherein the adhesive layer contains a thermoplastic elastomer, and a non-volatile hydrocarbon oil in more than 50 parts by weight and not more than 800 parts by weight per 100 parts by weight of the elastomer, and the adhesive layer optionally further contains a tackifier at a content of not more than 10 wt %.Type: ApplicationFiled: September 28, 2013Publication date: December 31, 2015Inventors: Hiroyuki OGINO, Masaoki GOTO, Atsuyo HAMADA, Mitsuji AKAZAWA, Sadao YUKIMOTO
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Publication number: 20150224063Abstract: The present invention provides a patch containing an adhesive layer maintaining a drug, which is formed on a support, wherein the aforementioned adhesive layer comprises a thermoplastic elastomer, a non-volatile hydrocarbon oil in an amount exceeding 50 parts by weight and not more than 800 parts by weight per 100 parts by weight of the elastomer, and rivastigmine or a salt thereof, and the aforementioned adhesive layer optionally further contains a tackifier at a content in the adhesive layer of not more than 10 wt %.Type: ApplicationFiled: June 12, 2013Publication date: August 13, 2015Inventors: Hiroyuki Ogino, Masaoki Goto, Atsuyo Hamada, Mitsuji Akazawa, Sadao Yukimoto
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Publication number: 20150030666Abstract: The present invention provides an adhesive skin patch containing a support and an adhesive layer containing a drug which is formed on the support, wherein the adhesive layer comprises a thermoplastic elastomer, a liquid component in an amount exceeding 300 parts by weight per 100 parts by weight of the thermoplastic elastomer, a therapeutic drug having an anticholinergic activity or a salt thereof for overactive bladder as a drug, (A) a non-volatile hydrocarbon oil as a liquid component, and one or more kinds selected from the group consisting of (B) an amide solvent, (C) an alcohol solvent and (D) a liquid organic acid as a liquid component, or a fatty acid salt, and optionally comprises a tackifier at a content of not more than 10 wt % of the adhesive layer.Type: ApplicationFiled: November 28, 2012Publication date: January 29, 2015Inventors: Hiroyuki Ogino, Masaoki Goto, Atsuyo Hamada, Mitsuji Akazawa
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Publication number: 20140308335Abstract: The present invention provides transdermal absorption preparation having a support, and a drug-containing adhesive layer formed on the support, wherein a drug-containing adhesive layer contains donepezil or a salt thereof, and a higher fatty acid salt.Type: ApplicationFiled: September 7, 2012Publication date: October 16, 2014Applicant: KM TRANSDERM LTD.Inventors: Atsuyo Hamada, Mitsuji Akazawa, Keiko Yamasaki, Masaoki Goto