Patents by Inventor Mitsuko HIROSAWA-TAKAMORI

Mitsuko HIROSAWA-TAKAMORI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for inducing orexin neurons and agent for treating narcolepsy or eating disorder
    Patent number: 9480695
    Abstract: The invention provides a method for producing an orexin neuron by culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine and optionally in the presence of at least one inhibitor selected from the group consisting of a Sirtuin 1 inhibitor and an O-linked ?-N-acetylglucosamine transferase inhibitor. The invention also provides a therapeutic agent for narcolepsy or eating disorders, such as anorexia, containing N-acetyl-D-mannosamine, which is based on the induction of orexin neuron in vivo.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: November 1, 2016
    Assignee: The University of Tokyo
    Inventors: Kunio Shiota, Shintaro Yagi, Koji Hayakawa, Mitsuko Hirosawa-Takamori, Daisuke Arai, Keiji Hirabayashi
  • METHODS FOR INDUCING OREXIN NEURONS AND AGENT FOR TREATING NARCOLEPSY OR EATING DISORDER
    Publication number: 20140349964
    Abstract: The invention provides a method for producing an orexin neuron by culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine and optionally in the presence of at least one inhibitor selected from the group consisting of a Sirtuin 1 inhibitor and an O-linked ?-N-acetylglucosamine transferase inhibitor. The invention also provides a therapeutic agent for narcolepsy or eating disorders, such as anorexia, containing N-acetyl-D-mannosamine, which is based on the induction of orexin neuron in vivo.
    Type: Application
    Filed: March 25, 2014
    Publication date: November 27, 2014
    Inventors: Kunio SHIOTA, Shintaro YAGI, Koji HAYAKAWA, Mitsuko HIROSAWA-TAKAMORI, Daisuke ARAI, Keiji HIRABAYASHI