Patents by Inventor Mitsunobu Kawashima
Mitsunobu Kawashima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11932696Abstract: The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.Type: GrantFiled: December 28, 2020Date of Patent: March 19, 2024Assignees: SHIONOGI & CO., LTD., OSAKA UNIVERSITYInventors: Tetsuya Yoshida, Yujiro Kidani, Mitsunobu Matsumoto, Takayuki Kanazawa, Satomi Shinonome, Kanji Hojo, Naganari Ohkura, Shimon Sakaguchi, Atsushi Tanaka, Hisashi Wada, Atsunari Kawashima, Norio Nonomura
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Publication number: 20240082114Abstract: The present invention provides a dental cement that excels in ease of handling without its powder-to-liquid ratio greatly affecting ease of handling such as kneadability or ease of filling as compared to traditional dental portland cements, and that can provide a hardened material having excellent compressive strength. The present invention relates to a dental cement comprising a powder component and a liquid component, wherein: the powder component comprises a portland cement powder (A), the liquid component comprises water (C), and at least one of the powder component and the liquid component comprises a cationic surfactant (B). Preferably, the liquid component comprises the cationic surfactant (B).Type: ApplicationFiled: December 27, 2021Publication date: March 14, 2024Applicant: Kuraray Noritake Dental Inc.Inventor: Mitsunobu KAWASHIMA
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Patent number: 11452674Abstract: The present invention provides a non-solvent dental adhesive composition exhibiting high initial bond strength and high bond durability to a tooth structure (wet matter) and a high dentin cohesive failure rate on a tooth structure (wet matter) and being substantially free of water and an organic solvent. The present invention relates to a non-solvent dental adhesive composition comprising: an acid group-containing polymerizable monomer (A); a hydrophobic polymerizable monomer (B) having no acid group; and a water-soluble photopolymerization initiator (C) having a solubility of 10 g/L or more in water at 25° C.Type: GrantFiled: August 28, 2018Date of Patent: September 27, 2022Assignee: KURARAY NORITAKE DENTAL INC.Inventors: Yamato Nojiri, Mitsunobu Kawashima, Ryo Matsuura, Ryota Murayama
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Patent number: 11304879Abstract: The present invention provides a dental adhesive composition that, even after photocuring with a high-output LED irradiator, shows high bond strength not only for dentin untreated by phosphoric acid etching but also for dentin treated by phosphoric acid etching. The present invention relates to a dental adhesive composition comprising a phosphoric acid group-containing polymerizable monomer (A), the phosphoric acid group-containing polymerizable monomer (A) comprising: a dihydrogen phosphate monoester group-containing polymerizable monomer (A-1) represented by general formula (1); a hydrogen phosphate diester group-containing polymerizable monomer (A-2) represented by general formula (2); and a phosphoric acid tetraester group-containing polymerizable monomer (A-3) represented by general formula (3).Type: GrantFiled: April 19, 2019Date of Patent: April 19, 2022Assignee: KURARAY NORITAKE DENTAL INC.Inventors: Yamato Nojiri, Naoki Nishigaki, Mitsunobu Kawashima
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Publication number: 20220071852Abstract: The present invention provides a dental adhesive composition that exhibits high bond strength (initial bond strength and bond durability) to sandblasted zirconia. The present invention relates to a dental adhesive composition comprising a dihydrogen phosphate monoester group-containing polymerizable monomer (A) represented by a general formula (1) and a dihydrogen phosphate monoester group-containing compound (B) represented by a general formula (2). (The definitions of the symbols are omitted.Type: ApplicationFiled: December 20, 2019Publication date: March 10, 2022Applicant: KURARAY NORITAKE DENTAL INC.Inventors: Yamato NOJIRI, Naoki NISHIGAKI, Mitsunobu KAWASHIMA
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Publication number: 20210145701Abstract: The present invention provides a dental adhesive composition that, even after photocuring with a high-output LED irradiator, shows high bond strength not only for dentin untreated by phosphoric acid etching but also for dentin treated by phosphoric acid etching. The present invention relates to a dental adhesive composition comprising a phosphoric acid group-containing polymerizable monomer (A), the phosphoric acid group-containing polymerizable monomer (A) comprising: a dihydrogen phosphate monoester group-containing polymerizable monomer (A-1) represented by general formula (1); a hydrogen phosphate diester group-containing polymerizable monomer (A-2) represented by general formula (2); and a phosphoric acid tetraester group-containing polymerizable monomer (A-3) represented by general formula (3).Type: ApplicationFiled: April 19, 2019Publication date: May 20, 2021Applicant: KURARAY NORITAKE DENTAL INC.Inventors: Yamato NOJIRI, Naoki NISHIGAKI, Mitsunobu KAWASHIMA
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Publication number: 20200206091Abstract: The present invention provides a non-solvent dental adhesive composition exhibiting high initial bond strength and high bond durability to a tooth structure (wet matter) and a high dentin cohesive failure rate on a tooth structure (wet matter) and being substantially free of water and an organic solvent. The present invention relates to a non-solvent dental adhesive composition comprising: an acid group-containing polymerizable monomer (A); a hydrophobic polymerizable monomer (B) having no acid group; and a water-soluble photopolymerization initiator (C) having a solubility of 10 g/L or more in water at 25° C.Type: ApplicationFiled: August 28, 2018Publication date: July 2, 2020Applicant: KURARAY NORITAKE DENTAL INC.Inventors: Yamato NOJIRI, Mitsunobu KAWASHIMA, Ryo MATSUURA, Ryota MURAYAMA
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Patent number: 10231905Abstract: The present invention relates to providing a dental curable composition that, when cured, has high metal ion release ability and highly durable physical properties. The dental curable composition of the present invention includes: a sugar compound having an —XM group, where —X is an acid anion group and M is a metal cation; and a curable component.Type: GrantFiled: March 25, 2014Date of Patent: March 19, 2019Assignee: KURARAY NORITAKE DENTAL INC.Inventors: Mitsunobu Kawashima, Mitsuru Takei, Naoki Nishigaki, Shumei Ishihara, Kenji Hatanaka, Hiroshige Ishino, Akiko Tsuji
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Patent number: 9474826Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.Type: GrantFiled: October 9, 2015Date of Patent: October 25, 2016Assignees: National University Corporation Okayama University, Junsei Educational InstitutionInventors: Yasuhiro Yoshida, Masato Tanaka, Kazuomi Suzuki, Toshifumi Ozaki, Tomohiro Takahata, Masao Irie, Mariko Nakamura, Mitsunobu Kawashima, Yamato Nojiri, Koichi Okada, Masahiro Nagao
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Patent number: 9415068Abstract: A method for inhibiting dentinal hypersensitivity by applying a dentinal hypersensitivity inhibitor on a dentin surface. The dentinal hypersensitivity inhibitor contains at least one tetracalcium phosphate particle, an alkali metal salt of phosphoric acid, and at least one acidic calcium phosphate particle. The tetracalcium phosphate particle has an average particle diameter of 0.5 to 40 ?m. The dentinal hypersensitivity inhibitor contains a blended amount of the tetracalcium phosphate particle of 5 to 55 parts by weight relative to 100 parts by weight of a whole amount of the dentinal hypersensitivity inhibitor and a blended amount of the alkali metal salt of phosphoric acid of 1 to 100 parts by weight relative to 100 parts by weight of the tetracalcium phosphate particle.Type: GrantFiled: May 17, 2013Date of Patent: August 16, 2016Assignee: KURARAY NORITAKE DENTAL INC.Inventors: Tadashi Hashimoto, Mariko Sugiura, Shumei Ishihara, Mitsunobu Kawashima, Koichi Okada
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Publication number: 20160038382Abstract: The present invention relates to providing a dental curable composition that, when cured, has high metal ion release ability and highly durable physical properties. The dental curable composition of the present invention includes: a sugar compound having an —XM group, where —X is an acid anion group and M is a metal cation; and a curable component.Type: ApplicationFiled: March 25, 2014Publication date: February 11, 2016Applicant: KURARAY NORITAKE DENTAL INC.Inventors: Mitsunobu KAWASHIMA, Mitsuru TAKEI, Naoki NISHIGAKI, Shumei ISHIHARA, Kenji HATANAKA, Hiroshige ISHINO, Akiko TSUJI
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Publication number: 20160030627Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.Type: ApplicationFiled: October 9, 2015Publication date: February 4, 2016Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, JUNSEI EDUCATIONAL INSTITUTIONInventors: Yasuhiro YOSHIDA, Masato TANAKA, Kazuomi SUZUKI, Toshifumi OZAKI, Tomohiro TAKAHATA, Masao IRIE, Mariko NAKAMURA, Mitsunobu KAWASHIMA, Yamato NOJIRI, Koichi OKADA, Masahiro NAGAO
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Patent number: 9186433Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.Type: GrantFiled: February 22, 2011Date of Patent: November 17, 2015Assignees: National University Corporation Okayama University, Junsei Educational InstitutionInventors: Yasuhiro Yoshida, Masato Tanaka, Kazuomi Suzuki, Toshifumi Ozaki, Tomohiro Takahata, Masao Irie, Mariko Nakamura, Mitsunobu Kawashima, Yamato Nojiri, Koichi Okada, Masahiro Nagao
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Patent number: 8895680Abstract: The present invention relates to redox-curing type nonaqueous curable compositions having: at least one liquid radical polymeric monomer (a); an organic peroxide (b); and a powdered water-soluble reducing compound (c), where the powdered water-soluble reducing compound (c) is dispersed in the liquid radical polymeric monomer (a).Type: GrantFiled: August 8, 2005Date of Patent: November 25, 2014Assignee: Kuraray Noritake Dental Inc.Inventors: Mitsunobu Kawashima, Aki Takase
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Publication number: 20130251767Abstract: A method for inhibiting dentinal hypersensitivity by applying a dentinal hypersensitivity inhibitor on a dentin surface. The dentinal hypersensitivity inhibitor contains at least one tetracalcium phosphate particle, an alkali metal salt of phosphoric acid, and at least one acidic calcium phosphate particle. The tetracalcium phosphate particle has an average particle diameter of 0.5 to 40 ?m. The dentinal hypersensitivity inhibitor contains a blended amount of the tetracalcium phosphate particle of 5 to 55 parts by weight relative to 100 parts by weight of a whole amount of the dentinal hypersensitivity inhibitor and a blended amount of the alkali metal salt of phosphoric acid of 1 to 100 parts by weight relative to 100 parts by weight of the tetracalcium phosphate particle.Type: ApplicationFiled: May 17, 2013Publication date: September 26, 2013Applicant: KURARAY NORITAKE DENTAL INC.Inventors: Tadashi HASHIMOTO, Mariko SUGIURA, Shumei ISHIHARA, Mitsunobu KAWASHIMA, Koichi OKADA
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Publication number: 20120321596Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.Type: ApplicationFiled: February 22, 2011Publication date: December 20, 2012Applicants: Junsei Educational Institution, National University Corporation Okayama UniversityInventors: Yasuhiro Yoshida, Masato Tanaka, Kazuomi Suzuki, Toshifumi Ozaki, Tomohiro Takahata, Masao Irie, Mariko Nakamura, Mitsunobu Kawashima, Yamato Nojiri, Koichi Okada, Masahiro Nagao
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Publication number: 20120027829Abstract: A dentin mineralizing agent comprising tetracalcium phosphate particles (A) and an alkali metal salt of phosphoric acid (B), wherein the dentin mineralizing agent contains the tetracalcium phosphate particles (A) in an amount of 1 to 80 parts by weight relative to 100 parts by weight of the whole amount of the dentin mineralizing agent, and the blended amount of the alkali metal salt of phosphoric acid (B) relative to 100 parts by weight of the tetracalcium phosphate particles (A) is 1 to 100 parts by weight. Thus is provided a dentin mineralizing agent by which a dense HAp is formed on a dentin surface and HAp is deposited to a deep portion of a dentinal tubule, so that it can close the dentinal tubule.Type: ApplicationFiled: March 26, 2010Publication date: February 2, 2012Applicant: Kuraray Medical Inc.Inventors: Tadashi Hashimoto, Mariko Sugiura, Shumei Ishihara, Mitsunobu Kawashima, Koichi Okada
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Publication number: 20100240798Abstract: The present invention relates to processes of making a cured dental adhesive compositions, in contact with a wetting material surface, by contacting the wetting material surface having water present on the surface with a nonaqueous composition including at least one liquid radical polymeric monomer (a), an organic peroxide (b), and a water-soluble reducing compound (c) in the form of a solid, where the water-soluble reducing compound (c) is dispersed in the liquid radical polymeric monomer (a); and solvating the water-soluble reducing compound (c) present at an interface between the redox-curing nonaqueous curable composition and the wetting material with the water present on the wetting material surface.Type: ApplicationFiled: May 28, 2010Publication date: September 23, 2010Applicant: Kuraray Medical Inc.Inventors: Mitsunobu KAWASHIMA, Aki Takase
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Patent number: 7655722Abstract: The present invention relates to adhesive compositions having: a phosphate group-containing monomer (a) having a fluorocarbon group represented by Chemical Formula 1; and a solvent (b), where R is a hydrogen atom or a methyl group, n, p and q are natural numbers 2?n?10, p+q?n and p+q+n?13.Type: GrantFiled: April 13, 2006Date of Patent: February 2, 2010Assignee: Kuraray Medical Inc.Inventors: Kazumitsu Nakatsuka, Naoki Nishigaki, Mitsunobu Kawashima
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Publication number: 20090023856Abstract: The invention provides an adhesive composition including a specific phosphate group-containing monomer (a) having a fluorocarbon group, and a solvent (b). An adhesive composition that is suitably used in the fields of medical care, electronic industry, precision machinery industry, jewel industry and so on, exhibits high bond strength and high adhesive durability and is minimally varied in bond strength is provided. The adhesive composition of this invention exhibits high adhesive durability and high coloring resistance on dental restorative materials such as ceramics, a composite resin cured substance, porcelain and a metal, and in particular, on a novel dental restorative material such as hybrid ceramics or a metal oxide-based high strength ceramics, and therefore it is suitably used in the dental field.Type: ApplicationFiled: April 13, 2006Publication date: January 22, 2009Applicant: Kuraray Medical Inc.Inventors: Kazumitsu Nakatsuka, Naoki Nishigaki, Mitsunobu Kawashima