Patents by Inventor Mitsunobu Kawashima

Mitsunobu Kawashima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10550191
    Abstract: The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: February 4, 2020
    Assignees: Shionogi & Co., Ltd., Osaka University
    Inventors: Tetsuya Yoshida, Yujiro Kidani, Mitsunobu Matsumoto, Takayuki Kanazawa, Satomi Shinonome, Kanji Hojo, Naganari Ohkura, Shimon Sakaguchi, Atsushi Tanaka, Hisashi Wada, Atsunari Kawashima, Norio Nonomura
  • Patent number: 10231905
    Abstract: The present invention relates to providing a dental curable composition that, when cured, has high metal ion release ability and highly durable physical properties. The dental curable composition of the present invention includes: a sugar compound having an —XM group, where —X is an acid anion group and M is a metal cation; and a curable component.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: March 19, 2019
    Assignee: KURARAY NORITAKE DENTAL INC.
    Inventors: Mitsunobu Kawashima, Mitsuru Takei, Naoki Nishigaki, Shumei Ishihara, Kenji Hatanaka, Hiroshige Ishino, Akiko Tsuji
  • Patent number: 9474826
    Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: October 25, 2016
    Assignees: National University Corporation Okayama University, Junsei Educational Institution
    Inventors: Yasuhiro Yoshida, Masato Tanaka, Kazuomi Suzuki, Toshifumi Ozaki, Tomohiro Takahata, Masao Irie, Mariko Nakamura, Mitsunobu Kawashima, Yamato Nojiri, Koichi Okada, Masahiro Nagao
  • Patent number: 9415068
    Abstract: A method for inhibiting dentinal hypersensitivity by applying a dentinal hypersensitivity inhibitor on a dentin surface. The dentinal hypersensitivity inhibitor contains at least one tetracalcium phosphate particle, an alkali metal salt of phosphoric acid, and at least one acidic calcium phosphate particle. The tetracalcium phosphate particle has an average particle diameter of 0.5 to 40 ?m. The dentinal hypersensitivity inhibitor contains a blended amount of the tetracalcium phosphate particle of 5 to 55 parts by weight relative to 100 parts by weight of a whole amount of the dentinal hypersensitivity inhibitor and a blended amount of the alkali metal salt of phosphoric acid of 1 to 100 parts by weight relative to 100 parts by weight of the tetracalcium phosphate particle.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: August 16, 2016
    Assignee: KURARAY NORITAKE DENTAL INC.
    Inventors: Tadashi Hashimoto, Mariko Sugiura, Shumei Ishihara, Mitsunobu Kawashima, Koichi Okada
  • Publication number: 20160038382
    Abstract: The present invention relates to providing a dental curable composition that, when cured, has high metal ion release ability and highly durable physical properties. The dental curable composition of the present invention includes: a sugar compound having an —XM group, where —X is an acid anion group and M is a metal cation; and a curable component.
    Type: Application
    Filed: March 25, 2014
    Publication date: February 11, 2016
    Applicant: KURARAY NORITAKE DENTAL INC.
    Inventors: Mitsunobu KAWASHIMA, Mitsuru TAKEI, Naoki NISHIGAKI, Shumei ISHIHARA, Kenji HATANAKA, Hiroshige ISHINO, Akiko TSUJI
  • Publication number: 20160030627
    Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.
    Type: Application
    Filed: October 9, 2015
    Publication date: February 4, 2016
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, JUNSEI EDUCATIONAL INSTITUTION
    Inventors: Yasuhiro YOSHIDA, Masato TANAKA, Kazuomi SUZUKI, Toshifumi OZAKI, Tomohiro TAKAHATA, Masao IRIE, Mariko NAKAMURA, Mitsunobu KAWASHIMA, Yamato NOJIRI, Koichi OKADA, Masahiro NAGAO
  • Patent number: 9186433
    Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: November 17, 2015
    Assignees: National University Corporation Okayama University, Junsei Educational Institution
    Inventors: Yasuhiro Yoshida, Masato Tanaka, Kazuomi Suzuki, Toshifumi Ozaki, Tomohiro Takahata, Masao Irie, Mariko Nakamura, Mitsunobu Kawashima, Yamato Nojiri, Koichi Okada, Masahiro Nagao
  • Patent number: 8895680
    Abstract: The present invention relates to redox-curing type nonaqueous curable compositions having: at least one liquid radical polymeric monomer (a); an organic peroxide (b); and a powdered water-soluble reducing compound (c), where the powdered water-soluble reducing compound (c) is dispersed in the liquid radical polymeric monomer (a).
    Type: Grant
    Filed: August 8, 2005
    Date of Patent: November 25, 2014
    Assignee: Kuraray Noritake Dental Inc.
    Inventors: Mitsunobu Kawashima, Aki Takase
  • Publication number: 20130251767
    Abstract: A method for inhibiting dentinal hypersensitivity by applying a dentinal hypersensitivity inhibitor on a dentin surface. The dentinal hypersensitivity inhibitor contains at least one tetracalcium phosphate particle, an alkali metal salt of phosphoric acid, and at least one acidic calcium phosphate particle. The tetracalcium phosphate particle has an average particle diameter of 0.5 to 40 ?m. The dentinal hypersensitivity inhibitor contains a blended amount of the tetracalcium phosphate particle of 5 to 55 parts by weight relative to 100 parts by weight of a whole amount of the dentinal hypersensitivity inhibitor and a blended amount of the alkali metal salt of phosphoric acid of 1 to 100 parts by weight relative to 100 parts by weight of the tetracalcium phosphate particle.
    Type: Application
    Filed: May 17, 2013
    Publication date: September 26, 2013
    Applicant: KURARAY NORITAKE DENTAL INC.
    Inventors: Tadashi HASHIMOTO, Mariko SUGIURA, Shumei ISHIHARA, Mitsunobu KAWASHIMA, Koichi OKADA
  • Publication number: 20120321596
    Abstract: A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement.
    Type: Application
    Filed: February 22, 2011
    Publication date: December 20, 2012
    Applicants: Junsei Educational Institution, National University Corporation Okayama University
    Inventors: Yasuhiro Yoshida, Masato Tanaka, Kazuomi Suzuki, Toshifumi Ozaki, Tomohiro Takahata, Masao Irie, Mariko Nakamura, Mitsunobu Kawashima, Yamato Nojiri, Koichi Okada, Masahiro Nagao
  • Publication number: 20120027829
    Abstract: A dentin mineralizing agent comprising tetracalcium phosphate particles (A) and an alkali metal salt of phosphoric acid (B), wherein the dentin mineralizing agent contains the tetracalcium phosphate particles (A) in an amount of 1 to 80 parts by weight relative to 100 parts by weight of the whole amount of the dentin mineralizing agent, and the blended amount of the alkali metal salt of phosphoric acid (B) relative to 100 parts by weight of the tetracalcium phosphate particles (A) is 1 to 100 parts by weight. Thus is provided a dentin mineralizing agent by which a dense HAp is formed on a dentin surface and HAp is deposited to a deep portion of a dentinal tubule, so that it can close the dentinal tubule.
    Type: Application
    Filed: March 26, 2010
    Publication date: February 2, 2012
    Applicant: Kuraray Medical Inc.
    Inventors: Tadashi Hashimoto, Mariko Sugiura, Shumei Ishihara, Mitsunobu Kawashima, Koichi Okada
  • Publication number: 20100240798
    Abstract: The present invention relates to processes of making a cured dental adhesive compositions, in contact with a wetting material surface, by contacting the wetting material surface having water present on the surface with a nonaqueous composition including at least one liquid radical polymeric monomer (a), an organic peroxide (b), and a water-soluble reducing compound (c) in the form of a solid, where the water-soluble reducing compound (c) is dispersed in the liquid radical polymeric monomer (a); and solvating the water-soluble reducing compound (c) present at an interface between the redox-curing nonaqueous curable composition and the wetting material with the water present on the wetting material surface.
    Type: Application
    Filed: May 28, 2010
    Publication date: September 23, 2010
    Applicant: Kuraray Medical Inc.
    Inventors: Mitsunobu KAWASHIMA, Aki Takase
  • Patent number: 7655722
    Abstract: The present invention relates to adhesive compositions having: a phosphate group-containing monomer (a) having a fluorocarbon group represented by Chemical Formula 1; and a solvent (b), where R is a hydrogen atom or a methyl group, n, p and q are natural numbers 2?n?10, p+q?n and p+q+n?13.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: February 2, 2010
    Assignee: Kuraray Medical Inc.
    Inventors: Kazumitsu Nakatsuka, Naoki Nishigaki, Mitsunobu Kawashima
  • Publication number: 20090023856
    Abstract: The invention provides an adhesive composition including a specific phosphate group-containing monomer (a) having a fluorocarbon group, and a solvent (b). An adhesive composition that is suitably used in the fields of medical care, electronic industry, precision machinery industry, jewel industry and so on, exhibits high bond strength and high adhesive durability and is minimally varied in bond strength is provided. The adhesive composition of this invention exhibits high adhesive durability and high coloring resistance on dental restorative materials such as ceramics, a composite resin cured substance, porcelain and a metal, and in particular, on a novel dental restorative material such as hybrid ceramics or a metal oxide-based high strength ceramics, and therefore it is suitably used in the dental field.
    Type: Application
    Filed: April 13, 2006
    Publication date: January 22, 2009
    Applicant: Kuraray Medical Inc.
    Inventors: Kazumitsu Nakatsuka, Naoki Nishigaki, Mitsunobu Kawashima
  • Publication number: 20080081889
    Abstract: A nonaqueous curable composition including a liquid radical polymeric monomer (a), an organic peroxide (b) and a powdered water-soluble reducing compound (c) with the powdered water-soluble reducing compound (c) dispersed in the liquid radical polymeric monomer (a) is provided. According to the nonaqueous curable composition of this invention, time necessary for adhesion can be secured, and high adhesive strength against a wetting material, and more particularly, a biological hard tissue such as a dentine can be attained, and thus, the present invention is extremely industrially valuable.
    Type: Application
    Filed: August 8, 2005
    Publication date: April 3, 2008
    Applicant: KURARAY MEDICAL INC.
    Inventors: Mitsunobu Kawashima, Aki Takase
  • Patent number: 6984673
    Abstract: One embodiment of the invention provides a dental cement composition which includes (a) an acid group-having polymerizable monomer, (b) a polyalkenoic acid, (c) an ion-leachable glass filler, (d) a polymerizable monomer not having an acid group, (e) water, (f) a peroxide, (g) a salt of an aromatic sulfinic acid, and (h) an aromatic secondary amine and/or an aromatic tertiary amine.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: January 10, 2006
    Assignee: Kuraray Co., Ltd.
    Inventors: Mitsunobu Kawashima, Ikuo Omura, Mayumi Yamashita
  • Patent number: 6869984
    Abstract: The invention refers to a dental composition kit which comprises a combination of (A) a one-pack primer composition containing (a) an acid group-having polymerizable monomer and (b) an aromatic secondary amine and/or an aromatic tertiary amine, and (B) a cement composition containing (c) a polyalkenoic acid, (d) an ion-leachable glass filler, (e) a polymerizable monomer, (f) water, (g) a peroxide and (h) a salt of an aromatic sulfinic acid. A dental composition kit of this invention is easy to handle, and the cured product of the compositions bonds well to teeth. The kit is useful in restoring decayed or injured teeth and in bonding prostheses to teeth.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: March 22, 2005
    Assignee: Kuraray Co., Ltd.
    Inventors: Mitsunobu Kawashima, Ikuo Omura, Mayumi Yamashita
  • Publication number: 20030083398
    Abstract: The invention refers to a dental composition kit which comprises a combination of (A) a one-pack primer composition containing (a) an acid group-having polymerizable monomer and (b) an aromatic secondary amine and/or an aromatic tertiary amine, and (B) a cement composition containing (c) a polyalkenoic acid, (d) an ion-leachable glass filler, (e) a polymerizable monomer, (f) water, (g) a peroxide and (h) a salt of an aromatic sulfinic acid. A dental composition kit of this invention is easy to handle, and the cured product of the compositions bonds well to teeth. The kit is useful in restoring decayed or injured teeth and in bonding prostheses to teeth.
    Type: Application
    Filed: June 17, 2002
    Publication date: May 1, 2003
    Applicant: KURARAY CO. LTD.
    Inventors: Mitsunobu Kawashima, Ikuo Omura, Mayumi Yamashita
  • Publication number: 20030055123
    Abstract: One embodiment of the invention provides a dental cement composition which includes (a) an acid group-having polymerizable monomer, (b) a polyalkenoic acid, (c) an ion-leachable glass filler, (d) a polymerizable monomer not having an acid group, (e) water, (f) a peroxide, (g) a salt of an aromatic sulfinic acid, and (h) an aromatic secondary amine and/or an aromatic tertiary amine.
    Type: Application
    Filed: June 28, 2002
    Publication date: March 20, 2003
    Applicant: KURARAY CO. LTD,
    Inventors: Mitsunobu Kawashima, Ikuo Omura, Mayumi Yamashita
  • Patent number: 5908879
    Abstract: A coated particle is described, which includes a metal fluoride particle and a polysiloxane coating on the surface of the particle. A dental composition is also described, which includes the coated particle, a polymerizable monomer, and a polymerization initiator.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: June 1, 1999
    Assignee: Kuraray Co., Ltd.
    Inventors: Mitsunobu Kawashima, Kenichi Hino