Abstract: A lip closing tool can be configured to encourage an infant or the like to close his/her mouth unconsciously and keep his/her mouth closed, thereby encouraging formation of a habit of nasal respiration. The lip closing tool can include a lip contact portion that is contacted by the outer surface of the lips during use, and a main body that is configured to be disposed inside the oral cavity during use. The main body can include a teeth contact portion that is disposed on the outer surface of the teeth during use and extends in a left-right direction. A thin lip contacting portion can connect the lip contact portion to the teeth contact portion and can be contacted by the upper and lower lips during use. The teeth contact portion can be formed entirely and integrally from a flexible material. Stimulation portions can be provided by enlarging the volume of the teeth contact portion near the end of right and left paths thereof.

Abstract: Two genes implicated in arteriosclerotic diseases such as cerebral infarction were successfully identified by performing genome-wide correlation studies using SNPs by targeting the entire genome. Polymorphic mutations that can be used to examine the presence or absence of risk factors for arteriosclerotic diseases were successfully found on the genes. Subjects can be efficiently examined for the presence or absence of risk factors for arteriosclerotic diseases using the presence or absence of the polymorphic mutations as indicators. Furthermore, methods of screening for therapeutic agents for arteriosclerotic diseases are enabled by using expression or function of the genes as index.

Abstract: A lip closing tool can be configured to encourage an infant or the like to close his/her mouth unconsciously and keep his/her mouth closed, thereby encouraging formation of a habit of nasal respiration. The lip closing tool can include a lip contact portion that is contacted by the outer surface of the lips during use, and a main body that is configured to be disposed inside the oral cavity during use. The main body can include a teeth contact portion that is disposed on the outer surface of the teeth during use and extends in a left-right direction. A thin lip contacting portion can connect the lip contact portion to the teeth contact portion and can be contacted by the upper and lower lips during use. The teeth contact portion can be formed entirely and integrally from a flexible material. Stimulation portions can be provided by enlarging the volume of the teeth contact portion near the end of right and left paths thereof.