Abstract: A method of screening for an antidiabetic agent comprising (1) bringing a test substance into contact with a cell which overexpresses a polypeptide exhibiting an activity of suppressing insulin secretion under a high glucose concentration by an overexpression of the polypeptide in pancreatic ? cells, and comprising an amino acid sequence of SOCS-2 or a modified or homologous amino acid sequence thereof, under a high glucose concentration, and (2) measuring an amount of insulin secreted from the cell, or (1) bringing a test substance into contact with a cell transformed with a DNA fragment comprising a human SOCS-2 promoter sequence or a modified sequence thereof, (2) measuring an amount of expressed SOCS-2, and (3) selecting a substance which suppresses the amount of expressed SOCS-2, is disclosed.

Abstract: The object of this invention is to provide a method for efficiently identifying a disease susceptibility gene and, in particular, a disease susceptibility gene of a disease such as a multifactorial disease where a large number of genes are involved.

Abstract: An object in relation to a suspension for determining the sequence of genetic materials, a method of determining the sequence of genetic materials using such a suspension, and a method for high-speed scoring SNPs using such a suspension, is to ensure high reliability, and substantially increase reaction efficiency, to thereby shorten the time until reaching an equilibrium.

Abstract: Genomic sequence information consisting of four base sequences is input. It is determined whether there is a sequence portion in which any one of the bases is arranged continuously for, for example, ten in the input information. If there is such a sequence portion, base sequence information consisting of a predetermined number of bases continuously arranged forwards and rearwards of the sequence portion is extracted, and the extracted base sequence information is output.