Patents by Inventor Mitsuo Nishikawa
Mitsuo Nishikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090162932Abstract: A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.Type: ApplicationFiled: September 26, 2008Publication date: June 25, 2009Inventor: Mitsuo NISHIKAWA
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Publication number: 20090081221Abstract: The present invention provides a novel method for inhibiting cancer cell metastasis using an antibody against TM7XN1, a pharmaceutical composition to be used for the method, and a cancer-metastasis-suppressing agent comprising an antibody against TM7XN1 as an active ingredient.Type: ApplicationFiled: November 15, 2005Publication date: March 26, 2009Inventors: Yasuke Tokoro, Mitsuo Nishikawa
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Patent number: 7439332Abstract: A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.Type: GrantFiled: April 25, 2003Date of Patent: October 21, 2008Assignee: Kirin Pharma Kabushiki KaishaInventor: Mitsuo Nishikawa
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Publication number: 20080241207Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.Type: ApplicationFiled: November 19, 2007Publication date: October 2, 2008Inventors: Y. Tom Tang, Ivan Labat, Radoje T. Drmanac, Nancy Mize, Mitsuo Nishikawa, Cheng-Chi Chao
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Publication number: 20080241882Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes fro producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.Type: ApplicationFiled: November 16, 2007Publication date: October 2, 2008Inventors: Y. Tom Tang, Ivan Labat, Radoje T. Drmanac, Nancy Mize, Mitsuo Nishikawa, Cheng-Chi Chao
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Publication number: 20080227200Abstract: A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.Type: ApplicationFiled: November 26, 2007Publication date: September 18, 2008Inventors: Radoje T. Drmanac, Ivan Labat, Y. Tom Tang, Juhi Lee, Birgit Stache-Crain, Mitsuo Nishikawa
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Patent number: 7320880Abstract: A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.Type: GrantFiled: June 11, 2002Date of Patent: January 22, 2008Assignees: Nuvelo, Inc., Kirin Beer Kabushiki KaishaInventors: Mitsuo Nishikawa, Radoje T. Drmanac, Ivan Lobal, Y. Tom Tang, Juhi Lee, Birgit Stache-Crain
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Patent number: 7319141Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.Type: GrantFiled: October 19, 2004Date of Patent: January 15, 2008Assignees: Kirin Beer Kabushiki Kaisha, Nuvelo, Inc.Inventors: Y. Tom Tang, Ivan Labat, Radoje T. Drmanac, Nancy K. Mize, Mitsuo Nishikawa, Cheng-Chi Chao
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Publication number: 20050255546Abstract: A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.Type: ApplicationFiled: April 25, 2003Publication date: November 17, 2005Applicant: KIRIN BEER KABUSHIKI KAISHAInventor: Mitsuo Nishikawa
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Method and materials relating to novel stem cell growth factor-like polypeptides and polynucleotides
Publication number: 20050059073Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.Type: ApplicationFiled: October 19, 2004Publication date: March 17, 2005Inventors: Y. Tang, Ivan Labat, Radoje Drmanac, Nancy Mize, Mitsuo Nishikawa, Cheng-Chi Chao -
Patent number: 6824973Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.Type: GrantFiled: June 28, 2001Date of Patent: November 30, 2004Assignees: Kirin Beer Kabushiki Kaisha, Nuvelo Inc.Inventors: Y. Tom Tang, Ivan Labat, Radoje T. Drmanac, Nancy Mize, Mitsuo Nishikawa, Cheng-Chi Chao
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Publication number: 20040235160Abstract: An objective of the present invention is to provide a process for effectively producing hematopoietic stem cells. A process for producing hematopoietic stem cells comprises the step of culturing hematopoietic stem cells in the presence of a gp130 stimulating factor, one or more cytokines and stromal cells.Type: ApplicationFiled: February 9, 2004Publication date: November 25, 2004Inventors: Mitsuo Nishikawa, Masatake Osawa, Takahiko Ishiguro, Kiyoshi Yasukawa
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Publication number: 20040220396Abstract: A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.Type: ApplicationFiled: June 17, 2004Publication date: November 4, 2004Inventors: Mitsuo Nishikawa, Radoje T. Drmanac, Ivan Lobal, Y. Tom Tang, Juhi Lee, Birgit Stache-Crain
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Patent number: 6673904Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human and mouse secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from mouse bone marrow and human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, placental, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.Type: GrantFiled: July 24, 2001Date of Patent: January 6, 2004Assignees: Kirin Beer Kabushiki Kaisha, Hyseq, Inc.Inventors: Mitsuo Nishikawa, Ivan Labat, Radoje T. Drmanac, Y. Tom Tang, Cheng-Chi Chao, Nancy Mize, John Childs
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Publication number: 20030044792Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.Type: ApplicationFiled: June 28, 2001Publication date: March 6, 2003Inventors: Y. Tom Tang, Ivan Labat, Radoje T. Drmanac, Nancy Mize, Mitsuo Nishikawa, Cheng-Chi Chao
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Publication number: 20030022825Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human and mouse secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from mouse bone marrow and human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, placental, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.Type: ApplicationFiled: July 24, 2001Publication date: January 30, 2003Inventors: Mitsuo Nishikawa, Ivan Labat, Radoje T. Drmanac, Y. Tom Tang, Cheng-Chi Chao
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Patent number: 4851731Abstract: A flat type DC motor applicable for disc drive of an electronic still camera in which vibrations of the rotor axle are prevented without increasing manufacturing costs by providing the magnetic field between the stator and rotor to by asymmetrical so that the magnetic attracting force of the rotor to the stator is also asymmetrical. The asymmetrical attracting force causes the axle of the rotor to be urged in the same radial direction relative to the axle bearing in the stator, thus, movements of the axle in radial directions in the clearance between the axle and bearing of the stator are eliminated and the rotor rotates without vibrating.Type: GrantFiled: March 10, 1988Date of Patent: July 25, 1989Assignee: Sony CorporationInventors: Toshio Saotome, Yoshiyuki Noguchi, Mitsuo Nishikawa, Shigeki Yamazaki
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Patent number: 4788464Abstract: A disc spindle motor of the axial air-gap type includes a record disc chucking portion having a center boss with a disc support surface formed around the center boss. A magnet is arranged adjacent and beneath the disc support surface to hold a magnetic central core of the record disc against the support surface. The rotor of the spindle motor has a rotor magnet affixed to a rotor yoke and facing the stator coils. The center boss and disc support of the disc chucking portion and the rotor yoke of the rotor are all integrally formed in one piece by molding a resin, such as nylon-6, with a magnetic powder, such as iron powder.Type: GrantFiled: October 20, 1987Date of Patent: November 29, 1988Assignee: Sony CorporationInventors: Mitsuo Nishikawa, Souichi Murakami
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Patent number: 4156443Abstract: A binding lace for a novel automatic binder developed by the present inventors is disclosed. The binding lace is continuously thrusted from only one side of the binding lace into a lace guide positioned around an object to be bound and then travels while sliding along the lace guide without buckling to form loops of several turns overlapping each other. During travelling, the binding lace is sent in the lace guide without standing still, due to the properties of an outer portion and a core portion of the binding lace, while the binding lace always expands elastically outwardly in radial direction of the lace guide due to the larger rigidity and tensile stress of the core portion to hold a looped configuration with the loops having substantially the same diameter as the lace guide. After travelling stops, the binding lace is capable of holding the same diameter of the loops and a tip portion of the binding lace is held in the neighborhood of the overlap of the loops.Type: GrantFiled: August 22, 1977Date of Patent: May 29, 1979Assignee: Max Co., Ltd.Inventors: Mitsuo Nishikawa, Hideo Hosaka, Jun Maemori
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Patent number: 4094342Abstract: An automatic binding device or binder for binding a long material such as a bundle of electric wires with a lace by actuating the mechanisms associated therewtih according to pilot signals produced when the lace passes through the mechanisms. In this respect, a lace used should afford given rigidity and flexibility. This binder includes a guide member which may be opened and closed, and is formed with guide channels running along its inner peripheral surface for guiding a lace for use in binding. The guide member is formed with a lead-in hole for a lace on one side and a lead-out hole on the opposite side. For smooth guiding of a lace through guide channels, there is used a reversibly rotatable roller mechanism or a combination of the roller mechanism with a vibrating mechanism for vibrating a lace being guided through the guide channels. The lace paid out through the lead-out hole from the guide member is gripped by a lace gripping mechanism on the tip portion of the lace.Type: GrantFiled: February 22, 1977Date of Patent: June 13, 1978Assignee: Max Co., Ltd.Inventors: Mitsuo Nishikawa, Hideo Hosaka, Jun Maemori