Patents by Inventor Mitsuo Okubo

Mitsuo Okubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240096145
    Abstract: A noise generation cause identifying method and a noise generation cause identifying device are provided. A response correcting process corrects a sound signal obtained through a sound signal obtaining process based on obtained model information so that a frequency response of the obtained sound signal approaches a frequency response of a learning sound signal. A variable obtaining process obtains a variable output from a map by inputting the corrected sound signal to the map. A cause identifying process identifies a generation cause of a sound picked up by a microphone using the variable obtained through the variable obtaining process.
    Type: Application
    Filed: April 27, 2023
    Publication date: March 21, 2024
    Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Shinichi TAKEUCHI, Atsushi TABATA, Mitsuo OKUBO, Shingo NORITAKE, Akira MURAKAMI, Ryo YANAGAWA
  • Patent number: 8404803
    Abstract: First, to solve the problems of the present invention, the present inventors confirmed the presence of ovarian cancer antigen-specific T cells in the peripheral blood of ovarian cancer patients by using an experimental system that detects combinations of CD4 and IL-4 or IFN?. Next, using analogue peptides of the core protein MUC 16 of the ovarian cancer-associated antigen CA 125, the present inventors revealed that antigen-specific CD4-positive T cells are present at an average frequency of about 4% in the peripheral mononuclear cells of patients and healthy subjects. Then, the present inventors analyzed the epitope for T cells in the core protein MUC 16 of the ovarian cancer-associated antigen CA 125, and determined the amino acid sequence FTLNFTITN (SEQ ID NO: 1) to be a shorter epitope. The present inventors further discovered that the analogue peptide OVCA11: GHTAPGPLLVPFTLNFTITN (SEQ ID NO:11) is suitable for T cell activation.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: March 26, 2013
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Mitsuo Okubo, Hiroo Maeda, Satoru Takeda
  • Publication number: 20110229481
    Abstract: First, to solve the problems of the present invention, the present inventors confirmed the presence of ovarian cancer antigen-specific T cells in the peripheral blood of ovarian cancer patients by using an experimental system that detects combinations of CD4 and IL-4 or IFN?. Next, using analogue peptides of the core protein MUC16 of the ovarian cancer-associated antibody C125, the present inventors revealed that antigen-specific CD4-positive T cells are present at an average frequency of about 4% in the peripheral mononuclear cells of patients and healthy subjects. Then, the present inventors analyzed the epitope for T cells in the core protein MUC16 of the ovarian cancer-associated antigen CA125, and determined the amino acid sequence FTLNFTITN (SEQ ID NO: 1) to be a shorter epitope. The present inventors further discovered that the analogue peptide OVCA11: GHTAPOPLLVPFTLNFTITN (SEQ ID NO: 11) is suitable for T cell activation.
    Type: Application
    Filed: March 31, 2006
    Publication date: September 22, 2011
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Mitsuo Okubo, Hiroo Maeda, Satoru Takeda
  • Patent number: 7048879
    Abstract: A sheet-form structure of expandable thermoplastic resin is provided which is capable of undergoing a pseudo-one-dimensional expansion in its thickness direction and which enables manufacture of thermoplastic resin foams having reduced variations in thickness and weight precisions, increased compressive strength, and excellent properties such as surface smoothness. A method of manufacturing the sheet-form structure, as well as such thermoplastic resin foams, are also provided. A sheet-form structure 1 of expandable thermoplastic resin including granules 2 of expandable thermoplastic resin arranged generally uniformly for integral connection thereof through a thin film 3 of expandable thermoplastic resin.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: May 23, 2006
    Assignee: Sekisui Chemical Co., Ltd.
    Inventors: Tomoyuki Kobayashi, Kenji Miyazaki, Eiji Nagara, Michiaki Sasayama, Mitsuo Okubo
  • Publication number: 20040151723
    Abstract: An object of the present invention is to provide an epitope on a human papillomavirus antigen, which activates a CD4-positive T cell of a uterine cancer patient, and a CD4-positive T cell specific to cancerous and precancerous lesions of the uterus, which is activated by this epitope. An epitope according to the present invention comprises (a) the amino acid sequence of SEQ ID NO: 1, or (b) a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 1 that has one or more modifications selected from the group consisting of a substitution, a deletion, an addition and an insertion and can activate CD4-positive T cells specific to cancerous and precancerous lesions of the uterus.
    Type: Application
    Filed: December 4, 2003
    Publication date: August 5, 2004
    Inventors: Hiroo Maeda, Mitsuo Okubo
  • Patent number: 6716522
    Abstract: The present invention has for its object to provide a molded article of a thermoplastic composite material which is not only durable with little discoloration or fading even on prolonged outdoor exposure and is very satisfactory in physical properties and appearance qualities inclusive of wood-like texture but also has high productivity and good economics. The present invention is a method of producing a molded article of a thermoplastic composite material comprising extruding the thermoplastic composite material containing a thermoplastic resin and a vegetable filler, said vegetable filler content being 50 to 90 weight % of the total weight of said thermoplastic resin and said vegetable filler, wherein extrusion is carried out by means of an extrusion apparatus comprising at least an extruder, a hot shaping die, and a cooling die, said hot shaping die and cooling die being directly coupled.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: April 6, 2004
    Assignee: Sekisui Chemical Co., Ltd.
    Inventors: Koji Matsumoto, Masaki Ito, Koushi Kawabata, Keisuke Hashimoto, Mitsuo Okubo
  • Patent number: 6620495
    Abstract: A sheet-form structure of expandable thermoplastic resin is provided which is capable of undergoing a pseudo-one-dimensional expansion in its thickness direction and which enables manufacture of thermoplastic resin foams having reduced variations in thickness and weight precisions, increased compressive strength, and excellent properties such as surface smoothness. A method of manufacturing the sheet-form structure, as well as such thermoplastic resin foams, are also provided. A sheet-form structure 1 of expandable thermoplastic resin including granules 2 of expandable thermoplastic resin arranged generally uniformly for integral connection thereof through a thin film 3 of expandable thermoplastic resin.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: September 16, 2003
    Assignee: Sekisui Chemical Co., Ltd.
    Inventors: Tomoyuki Kobayashi, Kenji Miyazaki, Eiji Nagara, Michiaki Sasayama, Mitsuo Okubo
  • Publication number: 20030044594
    Abstract: A sheet-form structure of expandable thermoplastic resin is provided which is capable of undergoing a pseudo-one-dimensional expansion in its thickness direction and which enables manufacture of thermoplastic resin foams having reduced variations in thickness and weight precisions, increased compressive strength, and excellent properties such as surface smoothness. A method of manufacturing the sheet-form structure, as well as such thermoplastic resin foams, are also provided.
    Type: Application
    Filed: June 3, 2002
    Publication date: March 6, 2003
    Inventors: Tomoyuki Kobayashi, Kenji Miyazaki, Eiji Nagara, Michiaki Sasayama, Mitsuo Okubo
  • Publication number: 20020192401
    Abstract: The present invention has for its object to provide a molded article of a thermoplastic composite material which is not only durable with little discoloration or fading even on prolonged outdoor exposure and is very satisfactory in physical properties and appearance qualities inclusive of wood-like texture but also has high productivity and good economics.
    Type: Application
    Filed: April 4, 2002
    Publication date: December 19, 2002
    Inventors: Koji Matsumoto, Masaki Ito, Koushi Kawabata, Keisuke Hashimoto, Mitsuo Okubo
  • Patent number: 6399189
    Abstract: A sheet-form structure of expandable thermoplastic resin is provided which is capable of undergoing a pseudo-one-dimensional expansion in its thickness direction and which enables manufacture of thermoplastic resin foams having reduced variations in thickness and weight precisions, increased compressive strength, and excellent properties such as surface smoothness. A method of manufacturing the sheet-form structure, as well as such thermoplastic resin foams, are also provided. A sheet-form structure 1 of expandable thermoplastic resin including granules 2 of expandable thermoplastic resin arranged generally uniformly for integral connection thereof through a thin film 3 of expandable thermoplastic resin.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: June 4, 2002
    Assignee: Sekisui Chemical Co., Ltd.
    Inventors: Tomoyuki Kobayashi, Kenji Miyazaki, Eiji Nagara, Michiaki Sasayama, Mitsuo Okubo
  • Publication number: 20020064641
    Abstract: A sheet-form structure of expandable thermoplastic resin is provided which is capable of undergoing a pseudo-one-dimensional expansion in its thickness direction and which enables manufacture of thermoplastic resin foams having reduced variations in thickness and weight precisions, increased compressive strength, and excellent properties such as surface smoothness. A method of manufacturing the sheet-form structure, as well as such thermoplastic resin foams, are also provided.
    Type: Application
    Filed: August 25, 1998
    Publication date: May 30, 2002
    Inventors: TOMOYUKI KOBAYASHI, KENJI MIYAZAKI, EIJI NAGARA, MICHIAKI SASAYAMA, MITSUO OKUBO
  • Patent number: 6059413
    Abstract: A projection-type display device of the present invention includes a projection unit for projecting an image to be displayed on a screen and an angle-of-projection correcting mechanism supporting the projection unit. The angle-of-projection correcting mechanism is located at a side surface of the projection unit, instead of on a bottom surface thereof, to correct the projection angle of the image projected from the projection unit onto the screen, while reducing the size of the projection-type display device.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: May 9, 2000
    Assignee: Mitsubishi Denki Kabushiki Kaisha
    Inventor: Mitsuo Okubo