Patents by Inventor Mitsuru Imuta

Mitsuru Imuta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for reducing an .alpha. .beta.-unsaturated ketone
    Patent number: 5459264
    Abstract: A method for reducing an .alpha.,.beta.-unsaturated ketone of the present invention includes the step of treating the .alpha.,.beta.-unsaturated ketone with a silyl compound in the presence of a Lewis acid and alcohol to selectively reduce the carbonyl group of the .alpha.,.beta.-unsaturated ketone. According to this method, a deoxy-compound can be obtained from the .alpha.,.beta.-unsaturated ketone by selectively reducing the carbonyl group without reducing an .alpha.,.beta.-unsaturated bond.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: October 17, 1995
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Mitsuru Imuta, Makoto Kobayashi, Teruo Iizuka
  • Isoxazolidinyl carbapenem derivative
    Patent number: 5338733
    Abstract: A carbapenem derivative represented by Formula I: ##STR1## wherein R.sup.1 is hydrogen or a hydroxy protecting group; R.sup.2 is substituted or non-substituted lower alkyl; R.sup.3 is hydrogen, an inorganic or organic base, or a carboxy protecting group; and R.sup.4 is a compound represented by any of the following Formulae II through V: ##STR2## wherein R.sup.5 and R.sup.6 are independently substituted or non-substituted lower alkyl.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: August 16, 1994
    Assignee: Shionogi Seiyaku Kabushiki Kaisha
    Inventors: Mitsuru Imuta, Koichi Nishi
  • Process for producing halomethylcarbapenems
    Patent number: 5064954
    Abstract: A functionallized intermediate for antibacterial carbapenems, 2-halomethylcarbapenem (III) is effectively synthesized by treating 2-hydroxymethylcarbapenem (I) with a phosphorylating reagent to give 2-phosphoryloxymethylcarbapenem (II) and then treating this product with a halogenating reagent. Some carbapenems derived from the intermediate are also disclosed. ##STR1## wherein, R.sup.1 is hydrogen or substituted or unsubstituted alkyl;R.sup.2 is hydrogen or substituted or unsubstituted alkyl;R.sup.3, R.sup.4 is halogen or substituted or unsubstituted alkoxy or aryloxy;R.sup.5 is hydrogen or carboxy protecting group; andHal is halogen.
    Type: Grant
    Filed: October 10, 1990
    Date of Patent: November 12, 1991
    Assignee: Shionogi & Co., Ltd.
    Inventors: Shoichiro Uyeo, Mitsuru Imuta, Hisao Ona, Hikaru Itani