Patents by Inventor Mitsuru Mizuno
Mitsuru Mizuno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230414669Abstract: There are provided a production method for a therapeutic agent for arthrosis, in which a population including a plurality of mesenchymal stem cells being cultured is imaged to acquire a cell image, the cell image is analyzed to derive density information on the mesenchymal stem cells in the cell image, colonies, which are formed by the mesenchymal stem cells in the population, are detected based on the density information, and the population is sorted based on at least one of an average colony size or a colony forming unit, which is derived from the detected colonies, and provided a therapeutic agent for arthrosis, which is produced by the production method for a therapeutic agent for arthrosis.Type: ApplicationFiled: September 8, 2023Publication date: December 28, 2023Applicants: FUJIFILM Corporation, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Kentaro NAKAMURA, Shunsuke TOMINAGA, Ichiro SEKIYA, Mitsuru MIZUNO, Hisako KATANO, Nobutake OZEKI
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Publication number: 20230132346Abstract: An object of the present invention is to provide a production method for a synovium-derived mesenchymal stem cell, which makes it possible to obtain a sufficient amount of synovium-derived mesenchymal stem cells from the synovial tissue, a production method for a cell preparation for joint medical treatment using the production method for a synovium-derived mesenchymal stem cell, synovium-derived mesenchymal stem cell, and a cell preparation for a joint medical treatment. According to the present invention, there is provided a production method for a synovium-derived mesenchymal stem cell, which includes treating a synovial tissue with an enzyme for 2 hours or more; and washing a mixture after the enzyme treatment until a residual enzyme concentration in a supernatant is 0.5 ng/mL or less, to obtain a synovium-derived mesenchymal stem cell.Type: ApplicationFiled: December 23, 2022Publication date: April 27, 2023Applicants: FUJIFILM Corporation, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Ichiro SEKIYA, Mitsuru MIZUNO, Hisako KATANO, Nobutake OZEKI, Kentaro NAKAMURA, Tomomi YOSHIDA
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Publication number: 20230130549Abstract: An object of the present invention is to provide a production method for a synovium-derived mesenchymal stem cell, by which proliferation efficiency is improved so that a sufficient amount of synovium-derived mesenchymal stem cells can be obtained from a synovial tissue, a production method for a cell preparation for joint medical treatment using the production method for a synovium-derived mesenchymal stem cell, synovium-derived mesenchymal stem cell, and a cell preparation for a joint medical treatment. According to the present invention, there is provided a production method for a synovium-derived mesenchymal stem cell, which is a method of producing a synovium-derived mesenchymal stem cell from a synovial tissue, where the production method includes treating the synovial tissue with a mixed enzyme including one or more kinds of collagenases and one or more kinds of neutral proteases for 2 hours or more without causing the synovial tissue to undergo a disinfection step.Type: ApplicationFiled: December 23, 2022Publication date: April 27, 2023Applicants: FUJIFILM Corporation, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Ichiro SEKIYA, Mitsuru MIZUNO, Hisako KATANO, Nobutake OZEKI, Kentaro NAKAMURA, Tomomi YOSHIDA
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Publication number: 20190357524Abstract: An object of the present invention is to provide a preservative solution for human stem cells, a human stem cell suspension, and a method for preserving human stem cells, which enable preservation of human stem cells at a high survival rate for cells. According to the present invention, a preservative solution for human stem cells is provided. The preservative solution includes at least human serum, in which a volume ratio of human serum with respect to the entire preservative solution is 0.70 or more, and the human stem cells are preserved at a temperature higher than 0° C.Type: ApplicationFiled: August 9, 2019Publication date: November 28, 2019Applicants: FUJIFILM Corporation, National University Corporation Tokyo Medical and Dental UniversityInventors: Shinobu YANADA, Satoko HADA, Kento SUZUKI, Ichiro SEKIYA, Mitsuru MIZUNO, Hisako KATANO, Nobutake OZEKI, Kouji OTABE
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Publication number: 20130062476Abstract: A support arm includes a base, an intermediate member, a tip end member, a first parallel linkparallelogram mechanism provided between the base and the intermediate member and including a first arm and a second arm, and a second parallel linkparallelogram linkage mechanism provided between the intermediate member and the tip end member and including a third arm and a fourth arm. The first arm the second arm, the third arm, and the fourth arm are each formed in an L shape.Type: ApplicationFiled: April 28, 2010Publication date: March 14, 2013Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: Daisuke Ishii, Mitsuru Mizuno
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Publication number: 20120003311Abstract: It is an object of the present invention, in the case of a controlled-release pharmaceutical composition, particularly a pulsed-release pharmaceutical composition, containing an acid-unstable physiologically active substance, to provide a pharmaceutical composition having little variation in dissolution lag time and high reliability of dissolution characteristics. The present invention discloses a controlled-release pharmaceutical composition comprising: 1) a core containing an acid-unstable physiologically active substance and a disintegrant; and 2) a release-controlling coating which covers the core, and which contains a water-insoluble polymer, an enteric polymer and a hydrophobic wax.Type: ApplicationFiled: October 6, 2006Publication date: January 5, 2012Applicant: EISAI R&D MANAGEMENT CO., LTD.Inventors: Takashi Yoshitake, Mitsuru Mizuno, Kenji Moroshima, Shigeru Aoki
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Publication number: 20100105738Abstract: The invention provides extended release formulations of proton pump inhibitor, such as an extended release formulation of rabeprazole, comprising an amount of rabeprazole between 30 and 90 mg rabeprazole and having an AUC of between 900 and 1750 ng*hr/mL and other properties.Type: ApplicationFiled: October 4, 2007Publication date: April 29, 2010Inventors: Mitsuru Mizuno, Shigeru Aoki, Kiyoshi Iwamoto, Kenji Moroshima, Yasuhiro Zaima, Manabu Murakami, Yukio Horai, Takashi Seno, Norihiro Ueda
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Publication number: 20080095839Abstract: It is an object of the present invention, in the case of a controlled-release pharmaceutical composition, particularly a pulsed-release pharmaceutical composition, containing an acid-unstable physiologically active substance, to provide a pharmaceutical composition having little variation in dissolution lag time and high reliability of dissolution characteristics. The present invention discloses a controlled-release pharmaceutical composition comprising: 1) a core containing an acid-unstable physiologically active substance and a disintegrant; and 2) a release-controlling coating which covers the core, and which contains a water-insoluble polymer, an enteric polymer and a hydrophobic wax.Type: ApplicationFiled: March 23, 2005Publication date: April 24, 2008Applicant: EISAI R&D MANAGEMENT CO., LTD.Inventors: Takashi Yoshitake, Mitsuru Mizuno, Kenji Moroshima, Shigeru Aoki
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Patent number: 7220762Abstract: The present invention provides a method for stabilizing an oral solid formulation containing a benzimidazole-based compound or a physiologically acceptable salt thereof. That is, it provides a method for stabilizing a benzimidazole-based compound or a physiologically acceptable salt thereof, comprising incorporating 1) a crospovidone or a crospovidone and 2) sodium hydroxide and/or potassium hydroxide to a benzimidazole-based compound or a physiologically acceptable salt thereof.Type: GrantFiled: October 19, 2000Date of Patent: May 22, 2007Assignee: Eisai R&D Management Co., Ltd.Inventors: Koji Ukai, Satoshi Fujioka, Mitsuru Mizuno, Makoto Yokoyama, Shigeru Aoki, Masao Kawamura
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Publication number: 20070110806Abstract: It is an object of the present invention, in the case of a controlled-release pharmaceutical composition, particularly a pulsed-release pharmaceutical composition, containing an acid-unstable physiologically active substance, to provide a pharmaceutical composition having little variation in dissolution lag time and high reliability of dissolution characteristics. The present invention discloses a controlled-release pharmaceutical composition comprising: 1) a core containing an acid-unstable physiologically active substance and a disintegrant; and 2) a release-controlling coating which covers the core, and which contains a water-insoluble polymer, an enteric polymer and a hydrophobic wax.Type: ApplicationFiled: October 6, 2006Publication date: May 17, 2007Applicant: EISAI R&D MANAGEMENT CO., LTD.Inventors: Takashi Yoshitake, Mitsuru Mizuno, Kenji Moroshima, Shigeru Aoki
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Publication number: 20050142088Abstract: According to the present invention, a compound having a cholinesterase inhibiting action has a hair growth promoting action, and there is provided a hair growth promoting agent containing such a compound having a cholinesterase inhibiting action. Moreover, a compound having an acetylcholinesterase inhibiting action as the cholinesterase inhibiting action is preferable, and in particular donepezil hydrochloride has a good hair growth promoting effect. Furthermore, according to the present invention, there is provided a percutaneously applied preparation having a hair growth promoting action, containing a compound having a cholinesterase inhibiting action such as donepezil; the percutaneously applied preparation is preferably a liquid preparation, a cream, an ointment, a plaster or a tape preparation. Moreover, according to the present invention, there is also provided a scalp hair growth promoting method comprising the step of applying donepezil onto the scalp.Type: ApplicationFiled: February 7, 2003Publication date: June 30, 2005Inventors: Mitsuru Mizuno, Akira Kato, Takashi Kato