Abstract: A polymer represented by the following formula (I): wherein each symbol is as described in the specification, is useful as a drug carrier in effectively delivering a drug to a target site.

Abstract: A drug-polymer conjugate having thermoresponsiveness includes at least one drug conjugated to at least one end portion of at least one thermoresponsive polymer segment having a lower critical solution temperature. The drug-polymer conjugate is capable of forming a micellular aggregate in an aqueous medium at temperatures equal to or above the lower critical solution temperature. The drug-polymer conjugate or the micellular aggregate thereof may be administered to and absorbed in the lungs.

Abstract: The present invention provides a polyion complex micelle including an antisense oligonucleotide and a block copolymer of a cationic polymer and a PEG block having a number average molecular weight of 3 kDa to 10 kDa.

Abstract: A pharmaceutical composition includes polymer units ? and ?, each having a hydrophilic polymer chain bound to a cationic polymer chain, and a drug. The polymer units ? and ? are radially arranged such that the cationic polymer chains are directed inward and the hydrophilic polymer chains are directed outward, thereby forming a micelle with the drug encapsulated in the micelle. The cationic polymer chain of the polymer unit ? has a phenylboronic acid group in a side chain, and the cationic polymer chain of the polymer unit ? has a phenylboronic acid binding site in a side chain. The phenylboronic acid group and the phenylboronic acid binding site form a cross-linked structure that can dissociate in an acidic environment and/or in the presence of a substance capable of competitive binding.

Abstract: A pharmaceutical composition includes polymer units ? and ?, each having a hydrophilic polymer chain bound to a cationic polymer chain, and a drug. The polymer units ? and ? are radially arranged such that the cationic polymer chains are directed inward and the hydrophilic polymer chains are directed outward, thereby forming a micelle with the drug encapsulated in the micelle. The cationic polymer chain of the polymer unit ? has a phenylboronic acid group in a side chain, and the cationic polymer chain of the polymer unit ? has a phenylboronic acid binding site in a side chain. The phenylboronic acid group and the phenylboronic acid binding site form a cross-linked structure that can dissociate in an acidic environment and/or in the presence of a substance capable of competitive binding.

Abstract: A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.

Abstract: A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.

Abstract: An apparatus for producing a self-sealing pneumatic tire includes a rotational drive apparatus that grasps a vulcanization molded pneumatic tire and rotationally drives the pneumatic tire around a tire axis, together with a spray nozzle for a sealant material, a spray nozzle for a cover material, and an irradiating device that irradiates an electron beam, infrared rays, ultraviolet rays, or ultrasonic waves that are provided on a lateral part of the pneumatic tire grasped by the rotational drive apparatus in a manner such that each of the spray nozzles and the irradiating device can move in and out of a cavity of the pneumatic tire.

Abstract: A process in which a self-sealing pneumatic tire consisting of a pneumatic tire after vulcanization molding furnished with a sealant layer being uniform without thickness irregularity and a cover sheet layer therefore is produced without the use of an organic solvent and expensive apparatus; and an apparatus therefore.

Abstract: Provided is a tire puncture repair device capable of injecting a puncture sealing agent into a tire stably and speedily. A container is compressed between plate members by placing one of the plate members on the ground and pressing down the other one of the plate members with a foot. Thereby, the puncture sealing agent is discharged from the container and is injected into the tire through an injection tube. Discharge amount control means is attached to the injection tube to level an amount of the puncture sealing agent to be discharged.

Abstract: A pneumatic tire is described having a designated rotational direction, wherein drainage grooves in a tread portion are positioned on each side of a tire equatorial line extending at an angle in a direction opposite the rotational direction while curving towards an outside in the tire width direction. An inclination angle ?1 to the tire circumferential direction at the terminal center position of the leading side of the drainage grooves is from 0° to 45°, while an inclination angle ?4 to the tire circumferential direction at the terminal center position of the trailing side of the drainage grooves is from 65° to 90°. Land portions defined by a rib section continuously extend along the tire equatorial line and are further defined by a plurality of branched sections continuously extending and branched from the rib section towards the outside in the tire width direction.

Abstract: The present invention provides a run-flat support body and a tire/wheel assembly whose weights can be respectively reduced. The run-flat support body includes an annular shell and elastic rings, the annular shell having an outer peripheral side as a support surface and an inner peripheral side formed in fork-shaped open legs, the elastic rings being attached respectively to the legs portions of the annular shell, and the elastic rings being designed to be mounted on a rim of a wheel. The annular shell is formed of a porous structural material having fine voids. The run-flat support body is attached to an inside of a pneumatic tire mounted on the rim of the wheel.

Abstract: A process in which a self-sealing pneumatic tire consisting of a pneumatic tire after vulcanization molding furnished with a sealant layer being uniform without thickness irregularity and a cover sheet layer therefore is produced without the use of an organic solvent and expensive apparatus; and an apparatus therefore.

Abstract: A run flat support body for a pneumatic tire, including an annular shell and elastic rings, where the elastic rings are composed of a composite elastic material made by compounding reinforcement fillers with an elastic material so as to provide anisotropy to an effect of reinforcement thereof. Additionally, the compressive rigidity of the elastic rings in a radial direction of the tire is made larger than that of unreinforced elastic rings in the radial direction, and the bending rigidity of the elastic rings in an axial direction of the tire is made substantially equal to that of the unreinforced elastic rings in the axial direction. Preferably, the elastic rings include a layered body formed by alternately laminating layers of a composite elastic material in which short fibers are aligned in a circumferential direction and layers of a composite elastic material in which short fibers are aligned in the axial direction.

Abstract: The run-flat supporting body (1) is configured of the annular shell (2) and elastic rings (3) and (3). The annular shell (2) works as a supporting surface on an outer peripheral side, and bifurcates into two leg portions on an inner peripheral side. In addition, the annular shell (2) is provided with a large number of the through holes (4) in wall surfaces thereof. The elastic rings (3) and (3) are attached respectively to the two leg portions of the annular shell (2). The run-flat supporting body 1 is supported on a rim of a wheel with the elastic rings (3) and (3). According to a configuration of the present invention, peripheries of the respective through holes (4) are thickened, residual stresses are applied to the peripheries of the respective through holes (4), or each through hole (4) is formed into an elliptic shape having the major axis in a circumferential direction.

Abstract: Provided is a run-flat support for pneumatic tire, which support is improved in durability while still achieving a lightweight. A run-flat support 1 is constituted of an annular shell 2, and elastic rings 3. In a lateral cross section of the annular shell 2, the annular shell 2 has: an outer circumferential side formed in a plurality of convex support potions 2a each bulging outward, and a concave linking portion 2b linking the convex supporting portions 2a; and a pair of right and left leg portions 2c extending radially inward respectively from the supporting portions 2a on the corresponding sides in a bifurcating manner. The elastic rings are mounted respectively on ends of both leg portions of the annular shell 2.

Abstract: A run-flat support body and a method assembling the same that improves reliability during running by eliminating mechanical joint components and realizes weight reduction and uniform mass-production are provided. The run-flat support body of the present invention comprises a pair of elastic rings fitted to a rim of a wheel and an annular shell bridging between these elastic rings. In the run-flat support body, the elastic rings and the annular shells are integrally joined, at least one discontinuous spot is provided in a circumference of the annular shell and the elastic rings, a connection structure is formed in which butted ends of the annular shell are joined together by welding, and joining between the annular shell and the elastic ring is partially released in the vicinity of a butted position of the annular shell.

Abstract: Provided is a tire puncture repair device capable of injecting a puncture sealing agent into a tire stably and speedily. A container is compressed between plate members by placing one of the plate members on the ground and pressing down the other one of the plate members with a foot. Thereby, the puncture sealing agent is discharged from the container and is injected into the tire through an injection tube. Discharge amount control means is attached to the injection tube to level an amount of the puncture sealing agent to be discharged.

Abstract: Provided is a run-flat support body (1) for a pneumatic tire, in which an outer peripheral side of an annular shell (2) serves as a support surface for supporting an inner surface of the tire (T); an inner peripheral side of the annular shell (2) straddles in the form of a bifurcation; elastic rings (3) and (3) are attached respectively to two leg parts (2b) and (2b) of the annular shell (2); and the annular shell (2) is supported on a rim (Rm) of a wheel with the elastic rings (3) and (3). The elastic rings (3) and (3) are composed of a composite elastic material formed by compounding reinforcement fillers in an elastic material. Accordingly, compressive rigidity of the elastic rings in a radial direction of the tire is made larger than that of the unreinforced elastic rings in the tire radial direction, the unreinforced elastic rings being composed of a single elastic material in which the reinforcement fillers are not compounded.