Abstract: A method for assaying concentrations of Coenzyme A (CoA) molecules in biological samples with high sensitivity and high reproducibility, the method comprising a step of extraction from a biological sample using a strongly acidic solution, a step of solid phase extraction, a step of adding an internal standard substance, and a step of detection by LC-MS.

Abstract: A catalyst for producing a polyurethane, comprising a dialkylaminoalkyl alcohol represented by the formula (I): R1R2N—X—OH  (I) wherein each of R1 and R2 is independently an alkyl group having 1 to 4 carbon atoms; and X is a branched alkylene group having 4 to 8 carbon atoms; a process for producing a polyurethane, comprising reacting a polyol component with an isocyanate component in the presence of the above-mentioned catalyst for producing a polyurethane; and a process for producing a polyurethane foam, comprising reacting a polyol component with an isocyanate component in the presence of the above-mentioned catalyst for producing a polyurethane, and a compound having a primary amino group and a tertiary amino group in its molecule, and a blowing agent.

Abstract: A catalyst for producing a polyurethane, comprising a dialkylaminoalkyl alcohol represented by the formula (I):

Abstract: A process for producing a polyurethane foam comprising reacting a polyol component with an isocyanate component in the presence of a catalyst comprising a compound represented by the formula (I): wherein p is an integer of 4 to 8, and a compound having a primary amino group and a tertiary amino group in its molecule, a blowing agent and a surfactant. The polyurethane foam obtained by the process of the present invention can be suitably used for heat insulating materials for construction materials, electric refrigerators, refrigerated warehouses, baths and the like, interior materials for automobiles, and the like.

Abstract: A semi-rigid polyurethane foam having a strength retention of not less than 70% when allowing it to stand at 120° C. for 24 hours, and a Haze value of not more than 2 as determined by Fogging test, prepared by mixing a polyol mixture comprising a polyol, water and a catalyst with a polyisocyanate, and foaming the resulting mixture, and a process for preparing the same. The semi-rigid polyurethane foam would not cause fogging under high-temperature conditions, and can be suitably used for interior materials of automobiles such as headrests and armrests.

Abstract: The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method, novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients.

Abstract: The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method; novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following formula (I), is reacted with a basic agent, followed by intramolecular ring formation: ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group an alkenyl group, or an aryl group; R.sub.2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R.sub.3 represents a reactive carboxyl group; and R.sub.4 to R.sub.

Abstract: The present invention offers 7-aminoquinolinone derivatives, physiologically acceptable salts thereof, anti-allergic agents having as an active ingredient a 7-aminoquinolinone derivative or physiologically acceptable salt thereof, and 7-nitroquinolinone derivatives, wherein the 7-aminoquinolinone derivative is expressed by the following general formula (I): ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl group;R.sub.2 and R.sub.3 are mutually different groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups or alkenyl groups; andR.sub.4 and R.sub.5 are mutually different or identical groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups, alkenyl groups or aralkyl groups;and physiologically acceptable salts thereof.

Abstract: A urethane foam for shoe soles prepared by reacting a compound having at least two isocyanate-reactive hydrogen atoms and a molecular weight of 400 to 10000 with a polyisocyanate in the presence of a foam stabilizer, water and a catalyst, characterized in that the ratio r.sub.1 /r.sub.2 of a mean skill cell diameter r.sub.1 to a mean core cell diameter r.sub.2 is 0.02 to 0.80, wherein the mean skin cell diameter r.sub.1 is defined as the mean diameter of the cells which form the skin portion of a urethane foam extending from the surface to a depth of 5% of the foam thickness and the mean core cell diameter r.sub.2 is defined as the mean diameter of the cells which form the core portion of a urethane foam extending from a depth of 40% to a depth of 60% of the foam thickness.

Abstract: The present invention offers 7-aminoquinolinone derivatives, physiologically acceptable salts thereof, anti-allergic agents having as an active ingredient a 7-aminoquinolinone derivative or physiologically acceptable salt thereof, and 7-nitroquinolinone derivatives, wherein the 7-aminoquinolinone derivative is expressed by the following general formula (I): ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl group;R.sub.2 and R.sub.3 are mutually different groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups or alkenyl groups; andR.sub.4 and R.sub.5 are mutually different or identical groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups, alkenyl groups or aralkyl groups; and physiologically acceptable salts thereof.

Abstract: A polyester-polyol prepared by polycondensation of an acid component comprising terephthalic acid and adipic acid, and a polyhydric alcohol component, wherein the molar ratio of the terephthalic acid/adipic acid is 0.05 to 0.3; a process for preparing a polyurethane foam comprising reacting a polyisocyanate component and a polyol component, wherein the polyol component contains the above polyester-polyol; and a process for preparing a polyurethane foam comprising reacting an isocyanate prepolymer made of a polyisocyanate component and a polyol component (I) with a polyol component (II), wherein the polyol component (I) comprises the above polyester-polyol.

Abstract: Sand compositions containing a binder composition and a curing agent, in which the binder composition comprises (a) a binder comprising an acid-curable resin and (b) from 0.5 to 63.0% by weight, based on the binder composition, of at least one curing accelerator selected from compounds represented by formula (1): ##STR1## wherein X.sub.1, X.sub.2 each represent a hydrogen atom, a methyl group or an ethyl group;exhibit an increased curing rate to provide a casting mold having an increased initial strength.

Abstract: A 7-glycosyloxybenzopyran derivative represented by the following formula (I) ##STR1## wherein, R is a hydrogen atom, an acyl group, an alkyl group, a cycloalkyl group, an alkenyl group or an aralkyl group, R.sub.2 is a hydrogen atom, an alkyl group, a cycloalkyl group, an alkenyl group or an aralkyl group and R.sub.3 is a glycosyl group whose hydroxyl group is protected or not protected, selected from the group consisting of glucosyl, mannosyl and galactosyl groups, and physiologically acceptable salts thereof.

Abstract: There are provided novel compounds of the formulae I and II: ##STR1## and their physiologically acceptable salts. The compounds according to the present invention and their physiologically acceptable salts exhibit an antiallergic activity and are useful for treating allergic diseases.

Abstract: Sand compositions containing a binder composition and a curing agent, in which the binder composition comprises (a) a binder comprising an acid-curable resin and (b) from 0.5 to 63.0% by weight, based on the binder composition, of at least one curing accelerator selected from compounds represented by formula (1): ##STR1## wherein X.sub.1, X.sub.2 each represent a hydrogen atom, a methyl group or an ethyl group;exhibit an increased curing rate to provide a casting mold having an increased initial strength.

Abstract: The present invention relates to an extremely effective anti-allergic agent with a low toxicity, which possesses as its active ingredient a benzopyran derivative described by the general formula below (in the formula, R.sup.1 and R.sup.2 are each respectively a hydrogen atom, an acyl group, an alkyl group having 1.about.12 carbon atoms, or an alkenyl group having 2.about.10 carbon atoms; and R.sup.3 is a hydroxyl group, an acyloxy group, an alkoxy group having 1.about.10 carbon atoms, or an alkenyloxy group having 2.about.10 carbon atoms).

Abstract: An optical information recording medium according to the present invention is featured by its recording layer which contains a compound of tellurium (Te), selenium (Se) and nitrogen (N). The thickness of the recording layer 2 favorably ranges from about 100 angstroms (.ANG.) to about 1000 .ANG. and more favorably from 180 .ANG. to 400 .ANG.. The content of Se in the recording layer 2 favorably lies within a range from 2 to 40 atomic percent, more favorably from 10 to 30 atomic percent. The content of N is favorably to be from 2 to 20 atomic percent, and more favorably from 2 to 10 atomic percent.