Patents by Inventor Mitsuteru Hirata
Mitsuteru Hirata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7414066Abstract: The present invention provides to a novel compound having an ACAT inhibiting activity.Type: GrantFiled: November 9, 2004Date of Patent: August 19, 2008Assignee: Kowa Company Ltd.Inventors: Kimiyuki Shibuya, Toru Miura, Katsumi Kawamine, Yukihiro Sato, Tadaaki Ohgiya, Takahiro Kitamura, Chiyoka Ozaki, Toshiyuki Edano, Mitsuteru Hirata
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Patent number: 7393866Abstract: The present invention provides to a novel compound having an ACAT inhibiting activity.Type: GrantFiled: November 9, 2004Date of Patent: July 1, 2008Assignee: Kowa Company, Ltd.Inventors: Kimiyuki Shibuya, Toru Miura, Katsumi Kawamine, Yukihiro Sato, Tadaaki Ohgiya, Takahiro Kitamura, Chiyoka Ozaki, Toshiyuki Edano, Mitsuteru Hirata
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Patent number: 6969711Abstract: The present invention offers novel cyclic diamine compounds and a pharmaceutical composition containing the same. The present invention relates to a compound represented by the formula (I) or salt(s) or solvate(s) thereof. (In the formula, is an optionally substituted divalent residue of benzene, pyridine, cyclohexane or naphthalene or is a vinylene group where Ar is an optionally substituted aryl group; X is —NH—, oxygen atom or sulfur atom; Y is —NR1—, oxygen atom, sulfur atom, sulfoxide or sulfone; Z is a single bond or —NR2—; R1 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group; R2 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group; l is an integer of from 0 to 15; m is an integer of 2 or 3; and n is an integer of from 0 to 3).Type: GrantFiled: February 20, 2003Date of Patent: November 29, 2005Assignee: Kowa Company, Ltd.Inventors: Kimiyuki Shibuya, Katsumi Kawamine, Yukihiro Sato, Toru Miura, Chiyoka Ozaki, Toshiyuki Edano, Mitsuteru Hirata, Tadaaki Ohgiya
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Publication number: 20050131002Abstract: The present invention provides to a novel compound having an ACAT inhibiting activity.Type: ApplicationFiled: November 9, 2004Publication date: June 16, 2005Inventors: Kimiyuki Shibuya, Toru Miura, Katsumi Kawamine, Yukihiro Sato, Tadaaki Ohgiya, Takahiro Kitamura, Chiyoka Ozaki, Toshiyuki Edano, Mitsuteru Hirata
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Patent number: 6849647Abstract: The present invention provides to a novel compound having an ACAT inhibiting activity.Type: GrantFiled: September 20, 2000Date of Patent: February 1, 2005Assignee: Kowa Company, Ltd.Inventors: Kimiyuki Shibuya, Toru Miura, Katsumi Kawamine, Yukihiro Sato, Tadaaki Ohgiya, Takahiro Kitamura, Chiyoka Ozaki, Toshiyuki Edano, Mitsuteru Hirata
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Patent number: 6797717Abstract: The invention relates to a novel anilide compound and a pharmaceutical composition comprising the same. The invention relates to a compound represented by the following general formula: represents a divalent residue of benzene with a substituent(s), heterocycle-condensed benzene which may or may not have a substituent, pyridine which may or may not have a substituent, cyclohexane or naphthalene Ar represents an aryl group which may or may not have a substituent, X represents —NH—, oxygen atom or sulfur atom; Y represents —NR4—, oxygen atom, sulfur atom, sulfoxide or sulfone; Z represents single bond or —NR5—; R4 represents hydrogen atom, a lower alkyl group, an aryl group or a silylated lower alkyl group which may or may not have a substituent; R5 represents hydrogen atom, a lower alkyl group, an aryl group or a silylated lower alkyl group which may or may not have a substituent; and n represents an integer of 0 to 15.Type: GrantFiled: December 19, 2001Date of Patent: September 28, 2004Assignee: Kowa Company, Ltd.Inventors: Kimiyuki Shibuya, Katsumi Kawamine, Yukihiro Sato, Toshiyuki Edano, Mitsuteru Hirata, Chiyoka Ozaki
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Publication number: 20040038987Abstract: The present invention offers novel cyclic diamine compounds and a pharmaceutical composition containing the same.Type: ApplicationFiled: February 20, 2003Publication date: February 26, 2004Applicant: Kowa Company, Ltd.Inventors: Kimiyuki Shibuya, Katsumi Kawamine, Yukihiro Sato, Toru Miura, Chiyoka Ozaki, Toshiyuki Edano, Mitsuteru Hirata, Tadaaki Ohgiya
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Publication number: 20030087928Abstract: The invention relates to novel anilide compounds represented by the following formula IV: 1Type: ApplicationFiled: February 20, 2002Publication date: May 8, 2003Applicant: Kowa Company, Ltd., JapanInventors: Kimiyuki Shibuya, Katsumi Kawamine, Yukihiro Sato, Toshiyuki Edano, Mitsuteru Hirata, Chiyoka Ozaki
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Publication number: 20020099074Abstract: The invention relates to a novel anilide compound and a pharmaceutical composition comprising the same.Type: ApplicationFiled: December 19, 2001Publication date: July 25, 2002Applicant: Kowa Company, Ltd.,JapanInventors: Kimiyuki Shibuya, Katsumi Kawamine, Yukihiro Sato, Toshiyuki Edano, Mitsuteru Hirata, Chiyoka Ozaki
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Patent number: 6362208Abstract: The invention relates to a novel anilide compound and a pharmaceutical composition comprising the same. The invention relates to a compound represented by the following general formula: represents a divalent residue of benzene with a substituent(s), heterocycle-condensed benzene which may or may not have a substituent, pyridine which may or may not have a substituent, cyclohexane or naphthalene or Ar represents an aryl group which may or may not have a substituent; X represents —NH—, oxygen atom or sulfur atom; Y represents —NR4—, oxygen atom, sulfur atom, sulfoxide or sulfone; Z represents single bond or —NR5—; R4 represents hydrogen atom, a lower alkyl group, an aryl group or a silylated lower alkyl group which may or may not have a substituent; R5 represents hydrogen atom, a lower alkyl group, an aryl group or a silylated lower alkyl group which may or may not have a substituent; and n represents an integer of 0 to 15.Type: GrantFiled: December 6, 1999Date of Patent: March 26, 2002Assignee: Kowa Company, Ltd.Inventors: Kimiyuki Shibuya, Katsumi Kawamine, Yukihiro Sato, Toshiyuki Edano, Mitsuteru Hirata, Chiyoka Ozaki
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Patent number: 6337334Abstract: The present invention is directed to a pyrimidine derivative of the following formula (1) or a salt of the derivative: [wherein R1 represents a lower alkyl group; each of R2 and R3 represents H, alkyl, or alkoxy; each of R4 and R5 represents H or alkyl; R6 represents alkyl, —OR7, or —NR8R9; and n is a number between 0 and 3 inclusive (wherein each of R7, R8, and R9 represents H, alkyl, aryl, aralkyl, amino, a heterocyclic ring, etc.)], as well as to a medicine containing the derivative or salt as the active ingredient. The present compounds exhibit strong binding inhibitory activity against endothelin having potent vasoconstrictive effect and cell proliferation effect. Therefore, the compounds are effective as remedies for various diseases including circulatory diseases.Type: GrantFiled: November 5, 1999Date of Patent: January 8, 2002Assignee: Kowa Co., Ltd.Inventors: Mitsuteru Hirata, Takeo Deushi, Yoshio Takahashi, Masahiro Tamura, Takeshi Ohshima, Toshiaki Oda, Hiroyuki Sonoki, Masami Shiratsuchi
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Patent number: 6008224Abstract: The present invention is directed to a pyrimidine derivative of the following formula (1) or a salt of the derivative: ##STR1## [wherein R.sup.1 represents a lower alkyl group; each of R.sup.2 and R.sup.3 represents H, alkyl, or alkoxy; each of R.sup.4 and R.sup.5 represents H or alkyl; R.sup.6 represents alkyl, --OR.sup.7, or --NR.sup.8 R.sup.9 ; and n is a number between 0 and 3 inclusive (wherein each of R.sup.7, R.sup.8, and R.sup.9 represents H, alkyl, aryl, aralkyl, amino, a heterocyclic ring, etc.)], as well as to a medicine containing the derivative or salt as the active ingredient. The present compounds exhibit strong binding inhibitory activity against endothelin having potent vasoconstrictive effect and cell proliferation effect. Therefore, the compounds are effective as remedies for various diseases including circulatory diseases.Type: GrantFiled: June 27, 1997Date of Patent: December 28, 1999Assignee: Kowa Co., Ltd.Inventors: Mitsuteru Hirata, Takeo Deushi, Yoshio Takahashi, Masahiro Tamura, Takeshi Ohshima, Toshiaki Oda, Hiroyuki Sonoki, Masami Shiratsuchi
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Patent number: 5883092Abstract: The present invention is directed to a pyrimidine derivative of the following formula (1) or a salt of the derivative: ##STR1## ?wherein R.sup.1 represents a hydroxyl group, a lower alkoxy group, a phenyloxy group which may have a substituent, an aralkyloxy group which may have a substituent, or --NR.sup.2 R.sup.3 ; X represents an oxygen atom or N--R.sup.4 ; m is 2 or 3; and n is 1 or 2 (wherein each of R.sup.2 and R.sup.3, which are identical to or different from each other, represents a hydrogen atom, a hydroxyl group, a lower alkyl group which may have a substituent, a phenyl group which may have a substituent, an aralkyl group which may have a substituent, or a heterocyclic group which may have a substituent; R.sup.4 represents a lower alkyl group, a phenyl group, a formyl group, or a lower alkoxycarbonyl group)!, as well as to a medicine containing the derivative or salt as the active ingredient.Type: GrantFiled: March 4, 1998Date of Patent: March 16, 1999Assignee: Kowa Co., Ltd.Inventors: Mitsuteru Hirata, Takeo Deushi, Yoshio Takahashi, Masahiro Tamura, Takeshi Ohshima, Toshiaki Oda, Tetsuya Ishikawa, Hiroyuki Sonoki, Masami Shiratsuchi
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Patent number: 4898876Abstract: A benzopylpiperazine ester of the following formula: ##STR1## wherein A represents a single bond or an alkylene group, vinylene group, --O--alkylene group or methine group, R.sub.1 represents a bicyclic carbon ring residue which may be substituted with a lower alkyl group, lower alkoxy group, oxo group or nitro group or a halogen atom, or may be partially saturated; a fluorene residue which may contain an oxo group; a fluorenylidene group; an anthracene residue; a phenanthrene residue which may be substituted with a lower alkyl group, or may be partially saturated; a benzofuran residue or thianaphthene residue which may be substituted with a lower alkyl group or lower alkoxy group; a benzopyran residue or benzoazine residue which may be substituted with an oxo group or phenyl group and partially saturated; a phthalimide residue; a benzodiazine residue; an isozazole residue which may be substituted with a lower alkyl group or phenyl group; or an alkylene dioxybenzene residue or xanthene residue; and R.sub.Type: GrantFiled: November 12, 1985Date of Patent: February 6, 1990Assignee: Kowa Co., Ltd.Inventors: Setsuro Fujii, Eizou Hattori, Mitsuteru Hirata, Koichiro Watanabe, Kazuhiro Onogi, Masahiko Nagakura
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Patent number: 4746737Abstract: Novel benzoyl esters of the following formula (I), and acid addition salts thereof, ##STR1## in which R.sub.1 and R.sub.2 are the same or different and represent a hydrogen atom or a lower alkoxy group, A represents a single bond, a linear or branched lower alkylene group, a lower alkenylene group, R.sub.3 and R.sub.4 are the same or different and represent a hydrogen atom or a lower alkyl group, or R.sub.3 and R.sub.4 join together to form a lower alkylene group, R.sub.5 represents a group of the formula, --X--(CO).sub.Type: GrantFiled: July 16, 1986Date of Patent: May 24, 1988Assignee: Kowa Co., Ltd.Inventors: Setsuro Fujii, Eizou Hattori, Mitsuteru Hirata, Koichiro Watanabe, Tomio Ohta, Nobuo Yokoo, Masahiko Nagakura
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Patent number: 4620005Abstract: Phenyl tetrahydronaphthylcarboxylate of the formula: ##STR1## wherein A is a direct bond, or a lower alkylene, vinylene or imino group; B is a direct bond, a lower alkylene or --NH-lower alkylene group, or an --OCH.sub.2 CO-- residual group; and R is a lower alkyl group, with the proviso that A and B are not direct bonds simultaneously, and A, B and R are not a lower alkylene group, a direct bond and a methyl group, respectively, at the same time, are effectively useful as chymotrypsin inhibitors.Type: GrantFiled: October 17, 1985Date of Patent: October 28, 1986Assignee: Kowa Co., Ltd.Inventors: Setsuro Fujii, Eizou Hattori, Mitsuteru Hirata, Hisashi Kunieda, Koichiro Watanabe, Hiroshi Ishihama
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Patent number: 4605739Abstract: Benzoyl indolecarboxylates of the formula: ##STR1## where R.sup.1 is hydrogen, halogen, lower alkyl or lower alkoxy; R.sup.2 is hydrogen, lower alkyl, acetyl or benzoyl; R.sup.3 is hydrogen or lower alkyl; and A is a direct bond, or lower alkylene or vinylene substituted at the 2-, 3- or 5-position of the indole nucleus, are effective agents as chymotrypsin inhibitors.Type: GrantFiled: May 10, 1984Date of Patent: August 12, 1986Assignee: Kowa Co., Ltd.Inventors: Setsuro Fujii, Eizou Hattori, Mitsuteru Hirata, Hisashi Kunieda, Koichiro Watanabe, Hiroshi Ishihama
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Patent number: 4443603Abstract: A piperazine derivartive represented by the following formula: ##STR1## wherein R.sub.1 : an indolyl group which may optionally be substituted by one or more lower alkyl and/or lower alkoxy groups, naphthyl group which may optionally be saturated partially with 2 or 4 hydrogen atoms, or phenyl or cyclohexyl group which may optionally be substituted by one or more lower alkyl groups;A: a single bond or alkylene group;P: a single bond or vinylene group;Q: an -O-alkylene group or -NH-alkylene group when P is a single bond, or a single bond when P is a vinylene group; andR.sub.2 : a lower alkyl, morpholino-lower alkyl, morpholino-carbonyl lower alkyl, piperidinocarbonyl lower alkyl, piperazinocarbonyl lower alkyl or lower alkylaminocarbonyl lower alkyl group, or an acid addition salt thereof is a proteolytic enzyme inhibitor.Type: GrantFiled: May 24, 1982Date of Patent: April 17, 1984Assignee: Kowa Company LimitedInventors: Setsuro Fujii, Eizou Hattori, Mitsuteru Hirata, Koichiro Watanabe, Hiroshi Ishihama