Abstract: N,N'-disubstituted amide derivatives having potent and selective antagonistic action to 5-HT.sub.3 receptor have been developed by the present invention, which provides antagonistic drugs to 5-HT.sub.3 receptor containing novel N,N'-disubstituted amide derivatives represented by a general formula [I] ##STR1## (wherein R.sub.1 denotes a hydrogen atom or lower alkyl group, R.sub.2 and R.sub.3, which may be identical or different, denote respectively a hydrogen atom, lower alkyl group, lower alkenyl group, nonsubstituted or substituted aryl-lower alkyl group, acyl group or lower alkoxycarbonyl group, R.sub.4 denotes a hydrogen atom, lower alkyl group or lower alkoxy group, A denotes CH or N, and n denotes 1), their hydrates or acid addition salts.

Abstract: The following cyclic anthranilic acid derivative, their acid addition salts or alkali salts thereof represented by a general formula [I] are useful for antirheumatic drug, autoimmune disease curing drug and metabolic bone disease curing drug. ##STR1## wherein R.sup.1 to R.sup.6 and X are as defined in claim 1.

Abstract: Cyclic anthranilic acid acetic acid derivatives of the following formula, ##STR1## wherein R.sup.1 and R.sup.2 each independently indicate a hydrogen atom, lower alkyl group having 1 to 3 carbon atoms; their acid or alkali salts thereof are useful as drugs treat autoimmune diseases, antirheumatic agents and therapeutic or prophylactic agents to treat metabolic bone diseases.

Abstract: Urea derivatives of the following formula: ##STR1## wherein R.sub.2 indicates a piperidino or pyrrolidino group which may be substituted with a hydroxy group or a lower alkyl group having 1 to 13 carbon atoms; A indicates an ethylene group, propylene group, butylene group or butenylene group; R.sub.2 indicates a straight or branched alkyl group having 1 to 20 carbon atoms, a benzyl group, or a phenyl group which may have 1 to 3 substituents such as a lower alkyl group having 1 to 6 carbon atoms, a lower alkoxy group having 1 to 3 carbon atoms, a halogen atom, a trifluoromethyl group, an amino group, a nitro group or a methylenedioxy group; and X indicates an oxygen or sulfur atom, as well as the hydrates and pharmaceutically acceptable salts thereof are useful antiulcer agents.

Abstract: Urea derivatives of the following formula, ##STR1## wherein R.sub.1 indicates a piperidino group or pyrrolidino group which may be substituted with hydroxy group or lower alkyl group having 1 to 3 carbon atoms; A indicates an ethylene group, propylene group, butylene group or butenylene group; R.sub.2 indicates a straight or branched alkyl group having 1 to 20 carbon atoms, cycloalkyl group having 3 to 6 carbon atoms, benzyl group, or phenyl group which may have 1 to 3 substituents such as lower alkyl group having 1 to 6 carbon atoms, lower alkoxy group having 1 to 3 carbon atoms, halogen atom, trifluoromethyl group, amino group, nitro group or methylenedioxy group; X indicates an oxygen or sulfur atom, the hydrates and pharmaceutically acceptable acid addition salts thereof are useful as antiulcer agents.