Abstract: A syringe for intratympanic injection, which allows secure recognition that an infusion in the syringe is at a temperature within a temperature range suitable for the administration into the tympanic cavity just before injection is provided. A syringe for tympanic injection 10 for direct injection of an infusion in a barrel 12 into the tympanic cavity, having first and second reversible temperature indicators 20.25 provided on an outer surface 12b of the barrel, wherein an indication based on difference temperatures at which the reversible temperature indicators 20.25 change in color allows visual recognition of a range of injection temperature suitable for administration into the tympanic cavity.

Abstract: The present invention relates to a film preparation having both rapid solubility and flexibility at the same time. The film preparation is characterized by comprising: an active-ingredient-containing layer comprising an active ingredient, a water-soluble polymer selected from the group consisting of methyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methyl cellulose, and a disintegrating agent; and an active-ingredient-free layer comprising methyl cellulose and/or hydroxypropyl methyl cellulose. It is further characterized in that the amount of the active ingredient is 0.1-75.0 mass % of a total mass of the film preparation and a total content of the active ingredient and the water-soluble polymer in the active-ingredient-containing layer is 15.0-95.0 mass % of a total mass of the active-ingredient-containing layer.

Abstract: The present invention relates to a film preparation having both rapid solubility and flexibility at the same time. The film preparation is characterized by comprising: an active-ingredient-containing layer comprising an active ingredient, a water-soluble polymer selected from the group consisting of methyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methyl cellulose, and a disintegrating agent; and an active-ingredient-free layer comprising methyl cellulose and/or hydroxypropyl methyl cellulose. It is further characterized in that the amount of the active ingredient is 0.1-75.0 mass % of a total mass of the film preparation and a total content of the active ingredient and the water-soluble polymer in the active-ingredient-containing layer is 15.0-95.0 mass % of a total mass of the active-ingredient-containing layer.

Abstract: A sweetener containing a Stevia-derived sweet substance is provided that, while containing cyclodextrin only in small amounts, can mask the bitter taste inherent in the Stevia-derived sweet substance. Cyclodextrin with a particle size of less than or equal to 30 ?m is blended into the Stevia-derived sweet substance at 0.5 to 20 mass % with respect to the mass of the Stevia-derived sweet substance.

Abstract: A pharmaceutical preparation for rectal administration by which a drug is retained in the affected region or the lower region of the rectum, where the drug is sustained-released is disclosed. The present invention is a pharmaceutical preparation for rectal administration comprising a coated drug-supported particle dispersed in a base, wherein the coated drug-supported particle is what a drug-supported porous microparticulate carrier is coated with a water-soluble polymer having a certain viscosity.

Abstract: A pharmaceutical composition for topical administration, which resides at a topical site of application for a long period and can control the release rate of an active agent, is provided. The present invention is a pharmaceutical composition for topical administration comprising an active ingredient, a water insoluble polymer, and a solvent capable dissolving the water insoluble polymer and compatible with water, and optionally containing other additive.

Abstract: A method and an apparatus are adapted to manufacture a tablet capable of quick disintegration in the oral cavity that has a sufficiently large porosity and can be disintegrated in the oral cavity in a very short period of time, typically between 3 and 5 seconds. A tablet manufactured by means of such a method and such an apparatus also constitutes part of the present invention. The method for manufacturing a tablet capable of quickly disintegration in the oral cavity comprises steps of punching a tablet out of a pharmaceutical composition containing one or more than one medicinal agents and one or more than one water-soluble saccharides under pressure between 0.20 and 0.01 t/cm2 and shaping the tablet by moisturizing and drying it, while transferring it without causing it to drop, said tablet having a porosity between 20 and 40%.