Abstract: Methods, systems, and apparatus, for generating in-situ resource guides. In one aspect, a method includes receiving flow elements for a resource, and for each flow element, identifying the respective resource instructions in the resource document that match a selector of the flow element; sequentially display flow interface elements, and for each sequentially displayed flow interface element: monitoring for the occurrence a user input of data in a user interface element corresponding to the selector of the flow element; and in response to monitoring the user input of data in a user interface element, sequentially displaying another flow interface element.

Abstract: The present invention is directed to N-[2-[[(diaminomethylene)amino]oxy]ethyl]-3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-s-oxo-1(2H)-pyrazineacetamide, pharmaceutical compositions containing said compound and methods of treatment comprising inhibiting a serine protease using said compound. The present invention is further directed to a process for the preparation of the N-[2-[[(diaminomethylene)amino]oxy]ethyl]-3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxo-1(2H)-pyrazineacetamide as a free base. The present invention is further directed to a process for the preparation of pharmaceutically acceptable salts of N-[2-[[(aminoiminomethyl)amino]oxy]ethyl]-3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxo-1(2H)-pyrazineacetamide.

Abstract: A system and method for managing collateral proffered in support of transactions involving financial instruments, wherein the collateral management is conducted in an integrated setting with other systems providing analytical and trading capabilities. The system is configured to execute a method which includes receiving terms of an agreement relating to collateral support for a transaction, storing the terms of the agreement as data in an agreement database, computing an exposure value representing the risk of financial loss associated with the transaction, comparing the computed exposure value with the threshold exposure value and initiating a transfer of collateral based on the comparison of the computed value with the threshold exposure value.