Abstract: A platinum-based drug/photosensitizer-loaded protein nanoparticle, and a preparation method therefor and an application thereof. The platinum-based drug/photosensitizer-loaded protein nanoparticle includes a platinum-based drug/photosensitizer complex, and a protein that encapsulates the platinum-based drug/photosensitizer complex. The prepared nanoparticles have a small particle size, are evenly dispersed and round in shape, and have good chemical stability, light stability, and high active oxygen generation capability when irradiated by near-infrared light; in cell experiments and animal experiments, it is verified that strong cytotoxicity to tumor cells and good in vivo tumor targeting are achieved, a synergistic effect is exerted, toxic and side effects are reduced, the use of chemotherapy and photodynamic therapy in combination to treat tumors is achieved, and metastasis of tumors is inhibited.

Abstract: A platinum sulfide protein nanoparticle having near-infrared photothermal effect and multi-modal imaging function, a preparation method therefor and an application thereof. The platinum sulfide nanoparticle having near-infrared photothermal effect and multi-modal imaging function is prepared in aqueous phase by means of formulation screening and process limitation. The nanoparticle has an ultra-small particle size and good stability as well as tumor targeting and photothermal effects and integrates functions of near-infrared imaging, CT imaging, and thermal imaging, so as to achieve high sensitivity, high resolution, and precise positioning of tumors, and to produce high-efficiency photothermal effects under the excitation of near-infrared light to kill tumor cells by thermal ablation, thereby achieving the purpose of efficient, safe, visual, and accurate treatment of tumors. The nanoparticle has the potential for further development and clinical application.

Abstract: A platinum sulfide protein nanoparticle having near-infrared photothermal effect and multi-modal imaging function, a preparation method therefor and an application thereof. The platinum sulfide nanoparticle having near-infrared photothermal effect and multi-modal imaging function is prepared in aqueous phase by means of formulation screening and process limitation. The nanoparticle has an ultra-small particle size and good stability as well as tumor targeting and photothermal effects and integrates functions of near-infrared imaging, CT imaging, and thermal imaging, so as to achieve high sensitivity, high resolution, and precise positioning of tumors, and to produce high-efficiency photothermal effects under the excitation of near-infrared light to kill tumor cells by thermal ablation, thereby achieving the purpose of efficient, safe, visual, and accurate treatment of tumors. The nanoparticle has the potential for further development and clinical application.