Patents by Inventor Miyako Sagara

Miyako Sagara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10076547
    Abstract: A modified coxsackievirus showing improved safety and/or aggressiveness to be used for oncolytic virotherapy is provided. A modified coxsackievirus showing tissue-specific suppression of proliferation and comprising a mutated genome consisting of the genome of coxsackievirus B3 wild-type (CVB3-WT) inserted with at least one polynucleotide consisting of a target sequence of tissue-specific microRNA (miRNA) is provided. The mutated genome is preferably further inserted with the region encoding GM-CSF in an expressible form.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: September 18, 2018
    Assignees: SHIN NIHON SEIYAKU CO., LTD, KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATION
    Inventors: Kenzaburo Tani, Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara
  • Publication number: 20160143969
    Abstract: A modified coxsackievirus showing improved safety and/or aggressiveness to be used for oncolytic virotherapy is provided. A modified coxsackievirus showing tissue-specific suppression of proliferation and comprising a imitated genome consisting of the genome of coxsackievirus B3 wild-type (CVB3-WT) inserted with at least one polynucleotide consisting of a target sequence of tissue-specific microR NA (miRNA) is provided. The mutated genome is preferably further inserted with the region encoding GM-CSF in an expressible form.
    Type: Application
    Filed: April 17, 2014
    Publication date: May 26, 2016
    Applicant: KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATION
    Inventors: Kenzaburo Tani, Shohei Miyamoto, Hiroyuki Inoue, Miyako Sagara