Abstract: An endoscope injection tool includes a needle body in a distal end of an elongated hollow inner tube, an elongated hollow outer tube allowing the inner tube to be insert longitudinally, an operation unit having an operation unit body attached to the proximal end of the outer tube and slider inserted in lumen of the operation unit body and moved longitudinally with the inner tube, and an inner guide, the outer tube has an expanded stopper in a base end for locking to a reduced diameter portion of the operation unit body when inserted from the proximal end of the operation unit body, the inner guide has a contact portion bringing the stopper of the outer tube into contact with the reduced diameter portion of the operation unit body so as to fix. The outer tube can be easily assembled and the needle body's protruded state can be easily determined.

Abstract: The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

Abstract: An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes which comprise at least three amino acids selected from the group consisting of the 8th, 11th, 12th, 13th, 14th, 16th, 17th, 22nd, 23rd, 176th, and 177th amino acids in the amino acid sequence of SEQ ID NO: 91.

Abstract: The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

Abstract: A hemostatic forceps (20) includes a pair of forceps elements (forceps cups (1)) constituted of a conductive metal and configured to serve as high-frequency electrodes and configured to be able to change into a state where front portions of the pair of forceps cups (1) are open, and a state where the pair of forceps cups (1) are close. A sawtooth portion (15) having a plurality of concavo-convex structures which constitute a sawtooth-shape is provided on at least one of respective closing-side surfaces (17) of the pair of forceps cups (1). The sawtooth portion (15) is provided with an electrically insulative coating over its bottom portion (21), but not on a top portion (22) thereof, and hence the top portion (22) is conductive.

Abstract: The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

Abstract: The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.

Abstract: Scissors (1) for an endoscope includes a treatment section (5) provided with a pair of scissor elements (10, 11) which are pivotably supported by a pivoting shaft (support pin (13)) and are pivotally displaced between an open position and a closed position; an operation wire (3) connected to the treatment section (5), and an operation section for displacing the scissor elements (10, 11) between the open position and the closed position by advancing and retracting the operation wire (3). A stopper (14) is provided to the treatment section (5). In the open position, the stopper (14) restricts the relative movement between the pair of scissor elements (10, 11) in the opening direction, and in the closed position, the stopper (14) restricts the relative movement between the pair of scissor elements (10, 11) in the closing direction, thereby to restrict excessive opening and closure of the scissor elements.

Abstract: An object of the present invention is to provide a monoclonal antibody binding to human XCR1, wherein the antibody binds to linear or discontinuous epitopes which comprise at least three amino acids selected from the group consisting of the 8th, 11th, 12th, 13th, 14th, 16th, 17th, 22nd, 23rd, 176th, and 177th amino acids in the amino acid sequence of SEQ ID NO: 91.

Abstract: The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

Abstract: Provided is a bipolar high frequency treatment device including a catheter tube insertable into a body through a treatment device passage of an endoscope; a first forceps blade and a second forceps blade at the top end of the catheter tube, which first forceps blade and second forceps blade can be opened and closed by operating from outside the body; a support member for supporting the first forceps blade and the second forceps blade so that the blades are able to open and close; and a voltage supplier for supplying a high frequency voltage to the first forceps blade and the second forceps blade, wherein the first forceps blade and the second forceps blade are electrically insulated with an insulating element.

Abstract: A therapeutic agent for an inflammatory disease comprising an antibody or a CX3CR1 antagonist that inhibits an interaction of fractalkine and CX3CR1 is provided.

Abstract: The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

Abstract: A clipping instrument for biological tissues equipped with an outer tube which can be inserted into a biological cavity, an operating member freely passed through the outer tube, an operating wire freely passed though the operating member, a self-opening holder which can be opened and closed by the action of the operating member attached to the edge of the operating wire, and a self-opening clop having a clipping member for clopping a biological tissue which is attached to the edge of the holder in a detachable manner by opening/closing the holder. Using this clopping instrument, a lesion site can be surely clipped over a long period of time in ligating a breeding site in a biological tissue, stitching a laceration, making in excision of a mucosal tissue and so on with an endoscope.

Abstract: The present invention features compositions and methods related to humanized antibodies and FKN-binding fragments thereof that bind fractalkine.

Abstract: Scissors (1) for an endoscope includes a treatment section (5) provided with a pair of scissor elements (10, 11) which are pivotably supported by a pivoting shaft (support pin (13)) and are pivotally displaced between an open position and a closed position; an operation wire (3) connected to the treatment section (5), and an operation section for displacing the scissor elements (10, 11) between the open position and the closed position by advancing and retracting the operation wire (3). A stopper (14) is provided to the treatment section (5). In the open position, the stopper (14) restricts the relative movement between the pair of scissor elements (10, 11) in the opening direction, and in the closed position, the stopper (14) restricts the relative movement between the pair of scissor elements (10, 11) in the closing direction, thereby to restrict excessive opening and closure of the scissor elements.

Abstract: The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.

Abstract: A hemostatic forceps (20) includes a pair of forceps elements (forceps cups (1)) constituted of a conductive metal and configured to serve as high-frequency electrodes and configured to be able to change into a state where front portions of the pair of forceps cups (1) are open, and a state where the pair of forceps cups (1) are close. A sawtooth portion (15) having a plurality of concavo-convex structures which constitute a sawtooth-shape is provided on at least one of respective closing-side surfaces (17) of the pair of forceps cups (1). The sawtooth portion (15) is provided with an electrically insulative coating over its bottom portion (21), but not on a top portion (22) thereof, and hence the top portion (22) is conductive.

Abstract: Disclosed is an ophthalmic composition for a soft contact lens, which is characterized in that the adsorption of a terpenoid contained in the composition onto a soft contact lens is reduced. The ophthalmic composition comprises a combination of Component (A) 0.005 to 0.01 wt % of a terpenoid and Component (B) alginic acid and/or a salt thereof.

Abstract: Disclosed is an ophthalmic composition for a soft contact lens, which is characterized in that the adsorption of a terpenoid contained in the composition onto a soft contact lens is reduced. The ophthalmic composition comprises a combination of Component (A) 0.005 to 0.01 wt % of a terpenoid and Component (B) alginic acid and/or a salt thereof.